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Custom CAR T Cells Made to Order

Chimeric antigen receptor (CAR) T cells are about as cutting-edge as cancer care gets today. Having demonstrated the ability to eradicate tumor cells in...

Transient Gene Expression Seeds Plant-Based Bioproduction Systems

Recent advances in plant biotechnology have allowed the use of plants and plant cell cultures for the production of pharmaceutical proteins, known as molecular...

Multiplex T-Cell Activation Assay Phenotypically Screens Kinase Inhibitors

T cells play a critical role in adaptive immune responses, including pathogen elimination, and tumor immunosurveillance. The binding of the T-cell receptor (TCR) to...

Multifunctional Potency Assays for Cancer Immunotherapy

Cancer immunotherapy is increasingly being evaluated as an approach to cancer treatment by harnessing the immune system to attack cancer cells. Both the adaptive...

Navigating the Challenges of Cell-Based Immunotherapies

Cell therapy is emerging, cell by cell, into the repertoire of medical therapies. However, it still has not broken into mainstream use. For instance,...

Quality and Polyfunctionality in Cell Therapy Development Can Broaden Therapeutic Options

Sponsored content brought to you by     Infusing a living cell therapy into patients to fight disease may have sounded far-fetched decades ago. Today, the results...

Evaluating Immunomodulation Therapeutics in Translationally-Relevant Humanized Mice

Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion by immune cells and improve...

Sequencing Platforms Make a Splash on Marco Island at AGBT Meeting

Despite single cell RNA technologies being front and center at the AGBT meeting in Marco Island, Florida, last week, two new DNA sequencing technology...

Merck KGaA, Pfizer Join BioXcel-Nektar Collaboration, Creating Triple Combination Therapy for Pancreatic Cancer

Pfizer and Merck KGaA, Darmstadt, Germany, have joined BioXcel Therapeutics in its clinical collaboration with Nektar Therapeutics, creating an expanded partnership of undisclosed value...

CRISPR Base Editor Takes Diagnostic and Remedial Exams

Base editors, new tools in the CRISPR toolbox, enable single-base corrections and could realize new biotech and clinical applications. Using a sequencing technique, scientists at South Korea’s Institute for Basic Sciences compared an adenine base editor with a cytosine base editor and a Cas9 nuclease. The results suggested different improvement strategies.

Sartorius Stedim Biotech, Novasep Partner on Membrane Chromatography

Sartorius Stedim Biotech said today it will partner with Novasep to develop novel systems for membrane chromatography and single-use bioprocessing, through a collaboration whose...

Proteins Fingerprinted by Measuring Their Microscopic Vibrations

Researchers report that they have developed a method for rapidly measuring proteins' unique vibrations, which help them perform vital tasks ranging from cell repair...

Colon Cancer Deadlier When Oral Bacterium Completes Feedback Loop

An oral bacterium, Fusobacterium nucleatum, was recognized years ago as a promoter of colon cancer. But exactly how F. nucleatum worsened colon cancer remained...

Biogen Replenishes Eye Disease Gene Therapy Pipeline with Planned $877M Nightstar Acquisition

Biogen has agreed to acquire Nightstar Therapeutics for approximately $877 million, the companies said today, in a deal that replenishes the buyer’s ophthalmology drug...

AI Improves Grading Tumor Patterns and Subtypes of Lung Cancer

Currently, lung adenocarcinoma requires pathologist's visual examination of lobectomy slides to determine the tumor patterns and subtypes. This classification has an important role in...

Pancreatic Cancer Genomic Profiling Hints at More Personalized Therapy

University of Pittsburgh scientists report the results of what they claim is the largest genomic profiling study of pancreatic ductal adenocarcinomas carried out to date, which has identified genomic signatures that may predict which tumors might be susceptible to chemotherapy. The study also found evidence for heritable genes which may predispose families to pancreatic cancer.

Blood Protein Helps Create 3D Nanofiber Scaffolds

It has been well established that there are a variety of plasma proteins playing essential roles in the wound healing process. Yet, the ability...

RNA-Editing Plant Proteins Take Root in Bacteria

In the mitochondria and chloroplasts of plants, a roundabout correction mechanism leaves DNA errors alone, but busily weeds away the corresponding errors in RNA...

ImmunoGen Shares Plunge after Phase III Failure of Lead ADC in Ovarian Cancer

ImmunoGen saw its shares lose more than half their value this morning after it acknowledged the failure of its lead antibody-drug conjugate mirvetuximab soravtansine...

Nicotine’s Harms to Fetus Studied at Single Cell Level

Stanford University School of Medicine-led team hopes that single cell sequencing of stem cell-derived embroidery bodies will help identify novel biomarkers to help doctors prevent, diagnose, and treat nicotine-induced fetal birth defects.

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