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Cancer’s Extreme Genomic Complexity Explained

Researchers have tracked the impact of the DNA-damaging chemical diethylnitrosamine to better understand how chemicals cause mutations in cells' DNA. Using an in vivo oncogenesis model, they discovered a clear pattern of mutations that led to the discovery of a new process known as lesion segregation. This work creates a profound shift in the understanding of how DNA repair and clonal proliferation can shape the cancer genome.

Protein and RNA Used to Create Vesicles for Potential Drug Delivery

Scientists from the University at Buffalo and Iowa State University use protein, RNA to make hollow, spherical sacks called vesicles that could potentially be engineered to deliver drugs.

Cytiva Upgrades Massachusetts CMO Site

Facility now totals 60,000 square feet and has bioprocessing capabilities ranging in scale from 10L to 2000L.

Reducing Sugar Uptake Increased Cancer Cells’ Sensitivity to Chemotherapy

Researchers at Lund University in Sweden have successfully increased cancer cells’ sensitivity to chemotherapy by preventing sugar uptake. More research is needed before it can be used in patients, but their findings open a door of understanding and treatment options for patients.

HIV Drug Candidate Opens “Shock and Kill” Possibilities

A bivalent, next-generation Smac mimetic called Ciapavir has been developed that has been shown to reactivate dormant human immunodeficiency virus (HIV) in a humanized mouse model. Ciapavir, its developers say, could enable “shock and kill” approaches because it operates in the “Goldilocks zone”—not so hot as to overactivate the immune system, not so cold as to preserve HIV’s latency.

Tell-Tale Tongue Telegraphs Tell-Tale Hearts

Researchers found that heart failure patients shared the same types of microorganisms in their tongue coating. Healthy people also shared the same microbes. There was no overlap in bacterial content between the two groups.

New Continuous Freeze-Dry Process for Single Vials

A continuous freeze-drier that moves single-dose vials along a track could help biomanufacturers improve product quality.

Aggregation Analysis

Is the protein-aggregation challenge on the rise in bioprocessing?

Axon to Leverage Existing CDMO Relationship for COVID Vaccine

Bachem, which has been working with Axon Neurosciences for more than 20 years, will play a critical role in manufacturing the vaccine for trials and beyond, specifically for production and initial commercial scaleup.

Sanofi Adds COVID-19, Flu Candidates to up to $2.3B+ mRNA Vaccine Partnership with Translate Bio

Sanofi and Translate Bio said their COVID-19 collaboration, which began in March, has progressed to evaluating multiple vaccine candidates in vivo for immunogenicity and neutralizing antibody activity, with the goal of supporting the selection of a lead candidate.

Alpine’s Gold Standard Approach to Drug Development

Mitchell H. Gold, MD, has gone from heading Dendreon, whose pioneering prostate cancer immunotherapy failed to meet initial sales expectations, to success as Founder and Managing Partner of life sciences investment firm Alpine BioVentures, and Executive Chairman and CEO of Alpine Immune Sciences.

Brain Tumor Detection Using DNA-Methylomes from Blood

A noninvasive way to diagnose brain cancer would be revolutionary for both patients and clinicians. Now, a team of researchers has moved one step closer to that goal with new research showing that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate brain tumors. This work may be the basis for a simple—but highly sensitive—blood test for brain cancer.

Hormone Used to Fight Obesity, Loses Fight against Sepsis

Researchers have discovered that the hormone, GDF15, which is often considered for use as a complementary therapy for obesity, could increase the risk of severe infection including sepsis.

Precision M&A: Invitae Eyes Growth in Personalized Cancer Tests, Services with Up-to-$1.4B ArcherDx Acquisition

The combined company plans to bring germline and somatic testing, liquid biopsy technologies and services, as well as tumor tissue genomic profiling onto a single platform.

Genetics May Play Key Role in Wound Healing

A first-of-its-kind study led by Texas Tech's Department of Biological Sciences and Natural Science Research Laboratory determines that genetics may play a role in how wounds heal. The identification of predictive biomarkers for chronic wound microbiomes may serve as risk factors and guide treatment by informing patient-specific tendencies of infection.

NHLBI, WHO, Novartis Halt Hydroxychloroquine Studies

The clinical setbacks—announced Saturday by the NIH and Wednesday by the WHO—come less than a week after the FDA repealed its emergency use authorization (EUA) for the controversial antimalarial drug.

Lifespan and Fertility Predicted through Rate of Mutation Accumulation

A study by University of Utah Health researchers found that differences in the rate that germline mutations accumulate in healthy young adults could help to predict relative lifespan in both sexes and the remaining years of fertility in women. Their results indicated that young adults who acquired fewer mutations over time lived about five years longer than those who acquired mutations more rapidly.

Scientists Discover Potential New Method for Treating Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a quickly progressing disease in which too many abnormal white blood cells are found in the bone marrow. AML is notoriously difficult to cure, due to its resistance to standard treatments. Now, scientists at the Children's Cancer Institute in Australia report they have discovered a potential new way to treat the poor-prognosis acute myeloid leukemia.

Muscle Finding Could Lead to New Therapies for Heart Disease and Skeletal Muscle Disorders

Scientists at the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association have developed a mouse model that enables them to look inside a working muscle and identify the proteins that allow the sarcomere to contract, relax, communicate its energy needs, and adapt to exercise.

Researchers Discover Key Structures in Kidney Formation

Renal fibrosis is a direct consequence of the kidney's limited capacity to regenerate after injury. Renal scarring results in a continuous loss of renal function, ultimately leading to end-stage renal failure and a need for dialysis or kidney transplantation. Now researchers at Massachusetts General Hospital have identified how key structures in the kidney are formed. Their findings could have important implications for treating renal fibrosis.

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