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Vitamin E Deficiency Tied to Abnormal Nervous System Development in Model Organism

A study by Oregon State University scientists found that the brains of embryos produced by vitamin E-deficient zebrafish were “absolutely physically distorted.” They claim the experiments represent a major step in determining the molecular basis of vitamin E in the developing vertebrate nervous system.

Cracking the Code of Cancer’s Complexities

In this GEN e-book, sponsored by 10x Genomics, learn more about how single cell RNA sequencing (scRNA-seq) and other emerging single cell and spatial analysis technologies are providing the resolution and scale to help answer these questions and more.

Illumina to Acquire Cancer Blood Test Developer GRAIL for $8B

The deal comes nearly five years after Illumina joined investors that included Bill Gates and Jeff Bezos in committing more than $100 million toward launching GRAIL in 2016, with the goal of commercializing a simple test that screens for multiple early-stage cancers by measuring circulating tumor DNA (ctDNA) in the blood.

Genetic Engineering Across the Tree of Life

Researchers turn to microorganisms beyond E. coli to broaden bioengineering toolbox.

See If Your Capsid Is Full of It: Easily Quantify and Characterize Full and Empty AAV

In this GEN webinar, sponsored by Unchained Labs, you will learn about some new tools and strategies to get you answers on empty/full ratio, quantification, aggregation, and the stability of your capsids with teeny-tiny sample volumes.

New Path for Preventing Chronic Myelogenous Leukemia Relapse Discovered

Chronic myelogenous leukemia (CML) is a type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood. Using mouse models, researchers from Hiroshima University have now discovered a new path to preventing CML relapse, especially in the face of drug resistance.

Gene Drive Control Worry Eased by Genetic Neutralizing Elements

CRISPR-Cas9-based tools that control the balance of genetic inheritance, known as gene drives, could reduce the burden of mosquito-borne infectious diseases. But their ability to efficiently spread throughout a target population raises concerns regarding their lack of control in the wild. Now, researchers have developed two active, guide RNA-only, genetic neutralizing elements that act as a mechanism of control by halting or deleting gene drives.

Stroke Linked to Dual Infection from Mosquito-Borne Viruses

A new study from investigators at the University of Liverpool has found that dual infections with Zika and chikungunya viruses may be a trigger for stroke. These viruses, which mostly circulate in the tropics, cause large outbreaks of rash and fever in Brazil and India. Zika is widely known to cause brain damage in babies following infection in pregnancy, but the new research shows it can also cause nervous system disease in adults.

Poxviruses Have Gene to “Blind” Host Cells’ DNA Sensors

A DNA sensor, the cGAS-STING pathway, is blocked by a cGAMP nuclease encoded by a gene in ectromelia virus, a mouse-specific pathogen that causes mousepox, a lethal disease that resembles human smallpox. The gene is highly conserved among poxviruses, and its action suggests that manipulation of DNA sensing would be an efficient therapeutic strategy in diseases triggered by viral infection or tissue damage–mediated release of self-DNA.

Digital Tools Push Single-Use Technology Challenges to the Side

In a previous podcast, we heard about the power of virtual collaborations during a pharmaceutical company’s push to meet their manufacturing goals during a...

New Rapid and Inexpensive Test Shows How Antibiotic Combinations Kill Bacteria

Scientists at Uppsala University say they have developed a new technique to determine how effective two antibiotics combined can be in stopping bacterial growth. The new method is simple for laboratories to use and can provide greater scope for customizing treatment of bacterial infections.

Scientists Solve High-Resolution Structure of Psychedelic Drugs Bound to Serotonin Receptors

Scientists at the University of California at Chapel Hill School of Medicine, and Stanford University School of Medicine, have solved the high-resolution structure of psychedelix drugs such as LSD and psilocybin, when actively bound to the 5-HT2A serotonin receptor (HTR2A) on the surface of brain cells. The researchers say this first glimpse of how such drugs act at the molecular level will provide key insights into how they work, and could accelerate the discovery of fast-acting antidepressants and potentially drugs to treat additional neuropsychiatric conditions, such as severe anxiety and substance use disorder.

Intestinal Organoid Built That Looks and Functions Like Real Tissue

Researchers have developed a method to guide stem cells to form "next-gen" organoids that look and function like real tissue. The method exploits the ability of stem cells to organize themselves along a tube-shaped scaffold that mimics the surface of the native tissue, placed inside a microfluidic chip. These “mini-intestines” retained physiological hallmarks of the intestine and had a notable capacity to regenerate.

Culprit Behind Immunotherapy Resistance in Some Lymphomas Revealed

Researchers from the University of Tsukuba in Japan, have demonstrated how the protein Livin—an apoptosis inhibitor—allows some lymphomas to resist therapy. Their findings may lead to strategies against aggressive non-Hodgkin lymphomas (NHL) including Burkitt lymphoma and diffuse large B-cell lymphoma.

Discarded Wound Dressings May Hold Key to Targeted Wound Healing Therapies

Thomas Jefferson University's novel way to sample the cells found at wounds is a noninvasive approach that opens a window into the cellular composition of wounds, and an opportunity to identify characteristics of wounds likely to heal versus those that become chronic, as well as inform the development of targeted therapies.

Takeda Opens New R&D Cell Therapy Manufacturing Facility

Five collaborative oncology cell therapy programs expected to be in clinical development by the end of FY2021.

Merck & Co. Commits Up to $4.2B toward Seattle Genetics Cancer Partnerships

The companies agreed to co-develop and co-commercialize globally Seattle Genetics’ Phase II antibody-drug conjugate (ADC) ladiratuzumab vedotin, while Merck was granted an exclusive license to commercialize Seattle Genetics’ marketed drug Tukysa® (tucatinib) in Asia, the Middle East, and Latin America, and other regions outside of the United States, Canada, and Europe.

West Nile Virus Transmission May Shift Due to Climate Change

Compared to more tropical pathogens like dengue and malaria, transmission of temperate viruses, like West Nile virus, has cooler optimal temperatures. A new model suggests that West Nile virus spreads most efficiently in the United States at temperatures between 24–25°C (75.2–77°F) and that climate change may increase the areas in the United States with optimal temperatures for West Nile virus transmission.

Most Deadly Form of Pancreatic Cancer Reveals Potential Therapeutic Targets

Scientists led by the Mayo Clinic and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, identified, in preclinical models, therapeutic targets for adenosquamous cancer of the pancreas (ASCP) and pinpointed already available cancer inhibitors originally designed for other types of cancer.

Bone Cancer Treatment Potentially Improved by Soy

Soy has been linked to the reduced risk of breast cancer, and has been shown to improve heart and bone health, as well as reduce the risk of other cancers. Now researchers at Washington State University (WSU) report the potential benefits of soy to improve post-operative treatment of bone cancer. They demonstrated the slow release of soy-based chemical compounds from a 3D-printed bone-like scaffold resulted in a reduction in bone cancer cells while building up healthy cells and reducing harmful inflammation.

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