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Protein-Protein Interactions

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A study of acquired heart failure implicates a protein clumping mechanism triggered by a mono-phosphorylated form of desmin. The study also shows that toxic clumping can be detected by positron emission tomography (PET). (Top) A PET scan detects clumping proteins in rat hearts. (Right) The enlarged heart is one with heart failure. (Bottom) Other PET scans showing blood flow in the rat hearts show that the protein clumps aren't due to circulation problems. [Courtesy of Circulation Research
Protein-Protein Interactions

Alzheimer’s-Like Clumping Proteins Found in Diseased Hearts

According to a new study from a Francis Crick Institute laboratory
Protein-Protein Interactions

Tumors Shrink, or Grow, Depending on Drug Receptor–Receptor Effect

Transmembrane proteins with multiple membrane-spanning regions have been designed by computer and shown to be highly stable when embedded in the plasma membrane in bacteria and mammalian cells. In this image
Protein-Protein Interactions

Designer Multipass Transmembrane Proteins the Latest Cellwear

Two intrinsically disordered proteins
Protein-Protein Interactions

Protein Binding Takes a Walk on the Unstructured Side

Protein-Protein Interactions

Gift of Protein Regulation Insight Marked “Some Disassembly Required”

Protein-Protein Interactions

Cancer’s Metabolic Off Ramp Found, Restoration of Normal Route Planned

Protein-Protein Interactions

Nuclear Pore Complex under Karyopherin-Centric Control

Protein-Protein Interactions

Protein Pair Help Transfer of Chromosomes to the Right Daughter Cell

Protein-Protein Interactions

Pain Management May Benefit from “Outside the Cell” Thinking about Phosphorylation

Protein-Protein Interactions

Protein “Social Networks” Mapped Using Novel Next-Gen Sequencing Technique

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