Works Seamlessly with Existing gRNA Infrastructure

Seamlessly Upgrade Your CRISPR Toolbox From Cas9 to Cas-CLOVER™

Over a decade ago, Cas9 came on the scene as the first RNA-guided nuclease, simplifying and expanding the use of gene editing. But now it’s time for an upgrade in performance and economy.
chip

How to Maximize the Potential of CRISPR

CRISPR-Chip technology optimizes gene editing by providing quantitative measurements of the underlying biochemical processes.
Viral mesh wire scenery

Synthetic Biology and Coronavirus: Preventing Future Pandemics

In this GEN webinar, sponsored by Codex DNA, our distinguished speaker, Dr. Silvi Rouskin, will focus much of her presentation on the biology of coronaviruses and how synthetic biology enables the study of coronavirus gene expression and recombination.
CRISPR-Cas9

CRISPR Method Boosts Efficiency and Yield Without Viral Vectors

A new variation of the CRISPR-Cas9 gene editing system engineers massive quantities of cells. The approach lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells. The researchers are seeking approval to advance clinical trials using nonviral CRISPR technology.
Mouse Karyotype with Fused Chr4+5

Sustainable Chromosome-Level Engineering is a Success in Mice

Researchers for the first time have successfully fused two chromosomes in mice and shown that the new karyotype can be transmitted to offspring. The researchers used a strategy that involved haploid embryonic stem cells and gene editing, illustrating the feasibility of sustainable, large-scale engineering of DNA in mammals.
Red and Green fluorescent proteins in Escherichia

Synthetic Biologists Use Novel Tool to “See” Signal Processing in Real Time

Bacteria use two-component systems to activate virulence and antibiotic resistance, colonize human and plant hosts, form biofilms and foul medical devices. In 2019, researchers unveiled a biohacking toolkit that synthetic biologists could use to mix and match tens of thousands of sensory inputs and genetic outputs from the circuits. One of the most important uses of that toolkit was unlocking the dual mystery of two-component systems.
Natural and synthetic embryos side by side

Synthetic Mouse Embryo with Brain and Beating Heart Grown from Stem Cells

University of Cambridge researchers harnessed stem cells to create model "synthetic" mouse embryos that comprise a brain, a beating heart, and the foundations of all the other organs of the body. The team mimicked natural processes, in the lab—and without the need for eggs and sperm—by guiding the three types of stem cells found in early mammalian development to the point where they interact.
Pittsburgh. PA

Biomanufacturing Goes to Pittsburgh Through UPitt, ElevateBio Partnership

ElevateBio and the University of Pittsburgh announced that they have entered into a long-term strategic partnership to accelerate the development of highly innovative cell and gene therapies. ElevateBio will locate one of its next BaseCamp process development and Good Manufacturing Practice (GMP) manufacturing facilities in Pittsburgh, fully equipped with its enabling technologies, including gene editing, induced pluripotent stem cell (iPSC) and cell, vector, and protein engineering capabilities.
Bioreactor

NIIMBL’s Tech and Training Ecosystem for Bioprocess Innovation

The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) is a public-private partnership whose mission is to accelerate biopharmaceutical innovation, support the development of standards that enable more efficient and rapid manufacturing capabilities, and educate and train a world-leading biopharmaceutical manufacturing workforce, fundamentally advancing U.S. competitiveness in this industry. NIIMBL is part of Manufacturing USA®, a diverse network of federally sponsored manufacturing innovation institutes.
Artwork of DNA Editing

CRISPR-Cas9 Alternatives: Cutting through the Boundaries of Gene Editing

In this GENcast, sponsored by Applied BioMath, we sat down with an expert in mechanistic modeling to discuss the specific of this approach and how companies are employing the technology successfully.