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Combination Therapies

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Combination Therapies

Melanoma Immunotherapy Most Effective in Older Patients

Disease-specific features of exhausted T cells have been revealed by epigenomic-guided mass cytometry profiling. Exhausted T cells have poor function in chronic infections and cancer but can be therapeutically reinvigorated. [John Wherry/Perelman School of Medicine at the University of Pennsylvania]
Combination Therapies

Exhausted T Cells Come in Different Flavors

Source: NIAID/NIH
Combination Therapies

Anticancer Virotherapy May Be Better If Backed by Natural Killer Overkill

Combination Therapies

Personalized Cancer Vaccine Shows Promise in Patients with Advanced Ovarian Cancer

Scientists devised a pinpointed immunotherapy regimen—intratumoral delivery of a TLR9 ligand with OX40 activation to ramp up T-cell responses—that eradicated tumors throughout the body in mice. [Sagiv-Barfi et al.
Combination Therapies

Local Immunotherapy Shrinks Tumors Near and Far

Combination Therapies

Kite, Pfizer to Assess Yescarta-Utomilumab Combination in Lymphoma

Combination Therapies

Cancer-Causing Mutations Also Boost Tumor Immunoresistance

Combination Therapies

Discovery of Second “Don’t Eat Me” Signal May Lead to Tighter...

Cell-based anticancer therapies may include synthetic T cells
Combination Therapies

Cancer Immunotherapies May Deploy Nonimmune Cells Engineered to a “T”

A synthetic biology approach that adds immunostimulatory gene circuits to cancer cells may contribute to combination immunotherapies against cancer. These circuits
Combination Therapies

Cancer Immunotherapy? There’s a Synthetic Gene Circuit for That

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