Drug Discovery

Synbio Modules Customize Cellular Input/Output, Add Anticancer Function

Cellular input and output revised with modular synthetic biology components to sensitize immune cells to a tumor signal

Study Shows Humabs Assay Distinguishes Zika from Other Flaviviruses

Humabs' NS1 BOB assay detects Zika virus infections and differentiates them from dengue and other flaviviruses, researchers from the company and UC Berkeley report

Cancer-Causing Mutations Also Boost Tumor Immunoresistance

Oncogenic mutations in Ras gene increase expression of PD-L1 checkpoint ligand

CRISPR Human Knockout Screens Identify New Target for ALS

U.S. researchers have used CRISPR/Cas9 screens to identify genes that may protect against or promote the toxicity of protein aggregates in amyotrophic lateral sclerosis (ALS).

United Therapeutics to Acquire SteadyMed for Up to $216M

SteadyMed’s lead product candidate is the drug–device combination Trevyent (treprostinil sodium), a subcutaneous treatment for pulmonary arterial hypertension whose NDA was rejected by the FDA last year

CAR-T Cells Just Got Some “Killer” Competition

Study finds that natural killer cells engineered with chimeric antigen receptors are equally effective and bring different advantages with less toxicity

Reputed Oncogene May Act as a Tumor Suppressor

Tumor suppressor activity attributed to the PLK1 gene, which has long been considered an oncogene because of its high expression in many tumors.

Lavender Scent Reduces Anxiety through Smell Receptors

Traditional medicine has long used aromatic plant-derived compounds such as lavender extract as treatments for anxiety, but how these compounds might work at the...

FDA Gives Abbott a Thumbs-Up for Automated HBV Monitoring Test

Assay can be used with the Abbott m2000 system to understand response to treatment.

Sanofi Sharpens Axe for Massive Layoffs

Cuts anticipated for 1,000–2,000 French workers.