Synbio Modules Customize Cellular Input/Output, Add Anticancer Function
Cellular input and output revised with modular synthetic biology components to sensitize immune cells to a tumor signal
Study Shows Humabs Assay Distinguishes Zika from Other Flaviviruses
Humabs' NS1 BOB assay detects Zika virus infections and differentiates them from dengue and other flaviviruses, researchers from the company and UC Berkeley report
Cancer-Causing Mutations Also Boost Tumor Immunoresistance
Oncogenic mutations in Ras gene increase expression of PD-L1 checkpoint ligand
CRISPR Human Knockout Screens Identify New Target for ALS
U.S. researchers have used CRISPR/Cas9 screens to identify genes that may protect against or promote the toxicity of protein aggregates in amyotrophic lateral sclerosis (ALS).
United Therapeutics to Acquire SteadyMed for Up to $216M
SteadyMed’s lead product candidate is the drug–device combination Trevyent (treprostinil sodium), a subcutaneous treatment for pulmonary arterial hypertension whose NDA was rejected by the FDA last year
CAR-T Cells Just Got Some “Killer” Competition
Study finds that natural killer cells engineered with chimeric antigen receptors are equally effective and bring different advantages with less toxicity
Reputed Oncogene May Act as a Tumor Suppressor
Tumor suppressor activity attributed to the PLK1 gene, which has long been considered an oncogene because of its high expression in many tumors.
Lavender Scent Reduces Anxiety through Smell Receptors
Traditional medicine has long used aromatic plant-derived compounds such as lavender extract as treatments for anxiety, but how these compounds might work at the...
FDA Gives Abbott a Thumbs-Up for Automated HBV Monitoring Test
Assay can be used with the Abbott m2000 system to understand response to treatment.
Sanofi Sharpens Axe for Massive Layoffs
Cuts anticipated for 1,000–2,000 French workers.
