Using AMDE Data to Cut Drug Toxicology Failures

Getting human ADME/Tox data at the early stages of drug development could have substantial payoffs in terms of lowering lead candidates’ toxicology. Developing in...

Catnip Biosynthetic Pathway Exhilarates Researchers

Catnip, the mint that intoxicates cats, also exerts an attraction for scientists. Thankfully, catnip doesn’t cause scientists to roll on the ground or otherwise...

Compound Library Profiling of Immunomodulators

Recent successes of immunomodulatory approaches for the treatment of serious diseases such as cancer have generated a significant growth in efforts aimed at the...

Lonza, Chr. Hansen Commit $101M to Microbiome-Based Drug CDMO Venture

Lonza and Chr. Hansen Holding have formed a 50/50 contract development and manufacturing (CDMO) joint venture that plans to spend €90 million ($101.1 million)...

Cholesterol-Ferrying Proteins Promote Buildup of Cardiovascular Plaque

Despite contributing to heart attacks and strokes, the migration of “bad” cholesterol into artery walls has been poorly understood. The bad cholesterol, or low-density...

Genentech, Parvus Therapeutics Launch Up-to-$800M Autoimmune Collaboration

Genentech, a member of the Roche Group, today launched an up-to-$800 million partnership with Parvus Therapeutics to develop, manufacture, and commercialize new treatments for...

Genetic Makeup Influences Immunity to Childhood Vaccines

Results of GWAS involving thousands of children may help scientists develop routine genetic tests to predict persistence of immunity to lifesaving vaccines.

Potential Diabetes Target Makes Subtle Changes with Big Impact on Metabolic...

Studies in mice showed how deactivating an enzyme that subtly modifies the ceramide leads to reduced total ceramide levels, and improved glucose and insulin control in obese animals, without changing their weight.

AI Identifies New Breast Cancer Subtypes That May Help Personalize Diagnosis...

Application of AI and machine learning to gene sequences and molecular data from breast tumors revealed, alongside patient survival data, revealed key differences among cancers that had previously been grouped into one type. The researchers say the results could help clinicians tailor treatment to individual patients, and could also help to inform the development of new treatments for different types of breast cancer.

Resistance Spreads Even without Antibiotic Use

Scientists from ETH Zurich and the University of Basel have now discovered an additional, previously unknown mechanism that spreads resistance in intestinal bacteria that is independent of the use of antibiotics.