Cellectis Details Proof-of-Concept for “Smart” CAR T-Cells

Cellectis researchers have published a proof-of-concept study detailing the activity of “smart” T-cells capable of sensing and reacting to tumors by secreting therapeutic proteins that improve their ability to fight cancerous cells, potentially paving the way for a next generation of tightly-controlled, highly active—and potentially safer—CAR T-cell treatments. By using gene editing to rewire the TCRα, CD25 and PD1 genes along the TCR activation pathway, CAR T-cells were able to reshape the tumor microenvironment by micro secreting the pro-inflammatory cytokine Interleukin 12 (IL-12) in a tumor- and time-dependent manner.

Targeting Epigenetic Enzymes for Drug Discovery and Development

The recent epigenetic drug discovery and development attention and investment is driven by the potential to develop novel therapeutic strategies that can effectively reverse transcriptional and epigenetic abnormalities that are present in many human disorders.

Inviragen and Duke-NUS Form Vaccine Partnership to Tackle Emerging Infectious Diseases

Collaboration will focus on infections including dengue fever, chikungunya and hand, foot and mouth disease.

Hamner Launches Systems Biology Collaboration

Effort will develop human cell-based assays that map, model key cell signaling pathways

FDA Approves Sanofi’s Dengue Prevention Vaccine Dengvaxia in Narrower Patient Population

Twenty-six years after it began development, Sanofi’s dengue prevention vaccine Dengvaxia® (Dengue Tetravalent Vaccine, Live) has won FDA approval—albeit in a narrower patient population...

Targeted Amplification System Developed to Improve Antibiotic Yield in Actinomycetes

Scientists exploit ZouA to amplify gene cluster between replication sites.

Making Vaccines from Parts

Researchers today report in Science Translational Medicine having successfully started and completed a synthetic flu vaccine virus in just one week.

IP-K Extends Collaborations with Sanofi-Aventis R&D and Novartis Tropical Disease Institute

Korean Institute will use PhenomicScreen to mine partners’ compound libraries.

Firms Offer iPSC Cardiac Toxicity Screening

Toxicity screening specialist CeeTox and stem cell technologies firm Cellular Dynamics have teamed up to devise and offer an in vitro predictive cardiac safety screening services using human induced pluripotent stem cell (iPSC)-derived cardiomyocytes.

Obesity Could Be Prevented by Blocking Single Gene

Studies in mice by an international team of scientists suggest that inhibiting a single gene could combat obesity and related metabolic disorders by allowing...

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