Second Guessing Second Messengers after cAMP Gradient Mapping

Contrary to previous assumptions, most cAMP molecules cannot move around freely in the cell, but are bound to certain proteins, particularly protein kinases. The upshot? The cAMP molecules won’t outpace cAMP-degrading enzymes, which form nanometer-sized domains around themselves that are almost free of cAMP. These domains allow cAMP to bring about distinct, highly localized downstream effects.

Pulmocide Raises $30.4M for Clinical Development of Inhaled Respiratory Drugs

Firm is developing small-molecule antiviral against RSV and triazole compound against pulmonary aspergillosis

Roche Shares Slide due to Avastin Failure in Phase III

Testing in early-stage colon cancer found that the drug would not reduce risk of recurrence. Negative results from Genentech's Phase III study with Avastin in early-stage...

Signs, Portents, and Immuno-Oncology Biomarkers

When translational researchers, drug developers, and clinical scientists seek immuno-oncology (IO) foresight, they often find it in biomarkers—or better still, the patterns formed by...

Purdue Pharma Files for Bankruptcy, in Pursuit of $10B Settlement

Purdue Pharma moved to carry out a more-than-$10 billion settlement with plaintiffs that include 24 U.S. states, more than 2,000 cities and counties, and five U.S. territories over claims that it illegally promoted its OxyContin opioid drug, contributing to the U.S. opioid epidemic by filing last night for reorganization under Chapter 11 of the U.S. Bankruptcy Code.

Ebola Vaccine Trial Launched in Mali

Partners to assess NIAID-developed, GSK-produced candidate; U.S.-Canadian team prepares to study its own vaccine soon

Regeneron Joins Human Vaccines Project

Regeneron brings scientific expertise, financial capital, and VelociSuite technology to the Human Vaccines Project.

FDA Clears Neurocrine’s VMAT2 Inhibitor as First Treatment for Tardive Dyskinesia

Oral drug Ingrezza beat's Teva's Austedo to U.S. approval for involuntary movement disorder

Opiant Eyes Q2 Launch for Pivotal Trial of Opioid Overdose Candidate...

Opiant Pharmaceuticals said this week it will launch a pivotal pharmacokinetics trial for its OPNT003 (nalmefene nasal spray) opioid overdose candidate in the second...

Ultrasound Drug Delivery

Researchers at MIT are using ultrasound waves to enable the rapid delivery of drugs to the gastrointestinal tract. This approach could make it easier to administer therapeutics to patients suffering from GI disorders.