Commensal Gut Bacteria May Help Switch off Immune Response to Cancer-Causing...

Researchers at the University of Chicago have found that some commensal bacteria may promote the development of leukemia caused by the murine leukemia virus in mice, by upregulating three genes that suppress the adaptive antitumor immune response. Two of the three negative immune regulators are known to be indicators of poor prognosis for humans with some forms of cancer, and the team suggests that their study may point to potential targets for cancer therapy.

Alcohol Triggers Transcriptomic and Epigenomic Changes in Brain’s Emotion Center

Even low doses of alcohol prime the brain for addiction by triggering changes in the epigenome and transcriptome, a new study on rodents shows. Using ATAC-seq, RNA-seq, and behavioral assays for anxiety in rats, scientists at the University of Illinois at Chicago found that alcohol increased global accessibility to the genome in the amygdala by inducing an open state in the normally tightly wound chromatin that resulted in changes in gene transcription.

Inducible VIPER CAR-T Immunotherapy Uses Approved Drug to Turn Cells On...

Scientists at Boston University College of Engineering have developed a new form of CAR-T cell immunotherapy that incorporates a built-in safety switch. The CAR-T cells can be switched on and off, or dialed up or down, making it possible to tailor treatment for the patient and prevent overstimulation of the immune system, which can otherwise lead to serious, potentially complications.

Antibiotics Given to Neonatal Mice Have Long-Term Effects on Microbiota and...

Researchers in the department of anatomy and physiology at the University of Melbourne in Australia say they published a study that demonstrates antibiotics given to neonatal mice have long-lasting effects which result in disturbed gastrointestinal function, including the speed of motility through the gut and diarrhea-like symptoms in adulthood. Thus, babies given antibiotics may grow up to experience gastrointestinal issues.

New Compound Shows Promise for Treating Chagas Disease

Researchers have identified a new compound that is 100% effective in treating mice and non-human primates infected with Trypanosoma cruzi, the parasite that causes Chagas disease. The compound, known as AN15368, appears to be safe, elicits no significant side effects, and is more effective than existing drugs. Human clinical trials are expected to commence in the next few years.

Anti-Diarrheal Drug Identified as Potential Therapy for Core Autism Symptoms

University of Oslo researchers identified the anti-diarrheal drug loperamide as a potential therapeutic candidate for key symptoms of autism spectrum disorder. Using computer modeling the investigators looked at how existing different drugs impact the complex network of protein interactions associated with ASD. Their results indicated that loperamide may counteract the biological process underlying some of the social interaction and communication deficits that are associated with ASD.

Manuka Honey Combination Therapy May Help Treat Lethal Lung Infection

Researchers at Aston University have developed a new strategy to potentially treat the lethal lung infection Mycobacterium abscessus. The researchers combined manuka honey and the drug amikacin in a lab-based nebulization formulation, which may pave the way for future research and treatments for the deadly lung infection.

Key Protein Identified that Helps Drive Rheumatoid Arthritis Damage

A research team characterized Sulf-2 expression in RA and investigated its potential role in TNF-α-induced synovial inflammation using primary human RA synovial fibroblasts (RASFs). Sulf-2 expression was significantly higher in serum and synovial tissues from patients with RA and in synovium and serum from hTNFtg mice. RNA sequencing analysis of TNF-alpha-stimulated RASFs showed that Sulf-2 siRNA modulated ~2500 genes compared to scrambled siRNA.

mRNA Vaccine Stabilization through Modulating LNP Composition and Utilizing Drying Technologies

In TOMORROW's GEN webinar, our distinguished guest, sponsored by Precision NanoSystems, Dr. Roland Böttger, will discuss aspects of mRNA stability, focusing on LNP formulation. Moreover, Dr. Böttger will show that the LNP composition is key to enabling advanced stabilization technologies such as dry mRNA presentation for storage at ambient temperatures.

Longevity Depends on Prompt Repair of Lysosomal Breaches

Scientists at the University of Pittsburgh have discovered a new signaling pathway (PITT) essential for rapid repair of breaches in the lysosomal membrane. The PITT pathway is activated by multiple disease-related conditions, and its loss exacerbates the spread of tau fibrils in the progression of Alzheimer’s disease. The discovery explains the mechanistic cause of severe neurodegeneration and premature aging in mouse models and humans deficient in the first enzyme in the PITT pathway.