Drug Discovery

L. lactis secreting proinsulin autoantigen and IL-10 triggers Treg production to suppress autoimmune responses.

In this GEN webinar, sponsored by Dotmatics, we will highlight key features of an informatics solution that supports research of novel, non-natural drug entities such as bicyclic and stapled peptides, antibody- and peptide-drug conjugates, and non-natural RNAs.

Preexisting, cross-reactive SARS-CoV-2 antibodies have been found in uninfected people, with higher levels found in children. The antibodies were likely generated during previous, seasonal coronavirus infections. Though cross-reactive immunity is not considered to be sterilizing nor long-lasting, the presence of cross-reactivity can reduce viral transmission and lessen symptoms. Together, these findings may provide insight into whether pre-established immunity to seasonal coronaviruses offers protection against SARS-CoV-2.

Oncothyreon selling stake to BVF to raise cash for clinical development of Array's ARRY-380

Alliance targets 11beta-HSD-1 for the treatment of metabolic syndrome disorders.

Amino acid reagents proposed as transient directing groups that can simplify the generation of drug candidates from starter molecules.

Both AstraZeneca's AZD1222, being co-developed with the University of Oxford, and J&J's JNJ-78436735 have potentially billions of dollars invested in them by Washington through “Operation Warp Speed,” the effort by President Donald Trump’s administration to deliver 300 million doses of COVID-19 vaccines by January 2021.

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Northwestern University researchers developed a way to increase by five-fold production yields of protein-based vaccines. The work builds on the team’s iVAX cell-free gene expression (CFE) platform for vaccine manufacture, which can quickly make shelf-stable vaccines at the point of care. The latest development has shown how enriching cell-free extracts with vesicles composed of cellular membrane improves glycoprotein synthesis, to vastly increase yields of the freeze-dried platform.

Companies aim to provide an integrated suite of services from R&D through to commercial cGMP.