Drug Discovery

As the life science industry faces increasing competition—as well as global regulatory and pricing pressures—outsourcing portions or all of manufacturing is becoming increasingly prevalent....

Eli Lilly will apply Dicerna Pharmaceuticals’ GalXC™ RNA interference (RNAi) technology platform to discover, develop, and commercialize new treatments based on more than 10...

In this webinar we will discuss the process involved in a typical molecular pathology laboratory.

The top 15 immuno-oncology collaborations' total value of all 15 ranked collaborations is approximately $30 billion.

Biophysical and chemical properties are critical factors that can dictate success or failure in the development of therapeutic antibodies. These attributes and all the functional characteristics of antibodies depend on amino acid sequence, post-translational modifications, and the solution environment. Early quality control and risk assessment of biophysical parameters help prevent failure in later stages of antibody development. An early-stage developability workflow was designed to set stage gate for molecules progressing to late-stage development. Application of the Uncle platform in antibody selection will be presented in this webinar. Stability analysis of engineered antibody variants was evaluated using Intrinsic Fluorescence Conformational Stability (T_m) and Colloidal Stability (T_agg). B₂₂/k_D parameters for monoclonal antibodies (mAbs) in solution were determined and validated by Small-Angle-X ray-scattering (SAXS). Quantitative correlation between T_agg and particle size for mAbs was observed in this study.

Who Should Attend

• Researchers developing monoclonal antibodies
• Drug discovery scientists
• Investigators interested in biologic stability
• Biochemists
• QC/QA scientists

You Will Learn

• How to use T_m and T_agg measurements to evaluate the stability of engineered antibodies
• How the aggregation propensity parameters B₂₂ and k_D can help further evaluate antibody variants
• How the Uncle platform can collect multiple measurements earlier, with less sample

The top public CRO ranked on this list is based outside the U.S., reflecting the industry’s desire to cut research costs by outsourcing the work overseas.

Scientists at Texas A&M University have identified a region in the brain that is involved in inhibiting fear, and which could feasibly lead to...

Researchers in Europe and Australia have developed an anti-obesity “chemical cigarette” that exploits the body’s natural responses to both cold exposure and smoking. The...

Study identified a metabolic vulnerability in the aggressive and incurable brain cancer glioblastoma and shown how it can potentially be exploited for therapy.

Scientists at the University of California San Diego (UCSD) have identified a gene that is involved in controlling the sensitivity of cancer cells to...