Custom Manufacturing Accelerates Time to Market

As the life science industry faces increasing competition—as well as global regulatory and pricing pressures—outsourcing portions or all of manufacturing is becoming increasingly prevalent....

Lilly, Dicerna Launch $3.7B+ RNAi Collaboration

Eli Lilly will apply Dicerna Pharmaceuticals’ GalXC™ RNA interference (RNAi) technology platform to discover, develop, and commercialize new treatments based on more than 10...

The Secret to Improving the Therapeutic Index of Antibody Drug Conjugates

In this webinar we will discuss the process involved in a typical molecular pathology laboratory.

Top 15 Immuno-Oncology Collaborations

The top 15 immuno-oncology collaborations' total value of all 15 ranked collaborations is approximately $30 billion.

Win More Biologics Development Battles with Early Stability Analysis

Biophysical and chemical properties are critical factors that can dictate success or failure in the development of therapeutic antibodies. These attributes and all the functional characteristics of antibodies depend on amino acid sequence, post-translational modifications, and the solution environment. Early quality control and risk assessment of biophysical parameters help prevent failure in later stages of antibody development. An early-stage developability workflow was designed to set stage gate for molecules progressing to late-stage development. Application of the Uncle platform in antibody selection will be presented in this webinar. Stability analysis of engineered antibody variants was evaluated using Intrinsic Fluorescence Conformational Stability (Tm) and Colloidal Stability (Tagg). B22/kD parameters for monoclonal antibodies (mAbs) in solution were determined and validated by Small-Angle-X ray-scattering (SAXS). Quantitative correlation between Tagg and particle size for mAbs was observed in this study.

Who Should Attend

  • Researchers developing monoclonal antibodies
  • Drug discovery scientists
  • Investigators interested in biologic stability
  • Biochemists
  • QC/QA scientists

You Will Learn

  • How to use Tm and Tagg measurements to evaluate the stability of engineered antibodies
  • How the aggregation propensity parameters B22 and kD can help further evaluate antibody variants
  • How the Uncle platform can collect multiple measurements earlier, with less sample

Top 7 CROs

The top public CRO ranked on this list is based outside the U.S., reflecting the industry’s desire to cut research costs by outsourcing the work overseas.

Fear in Mind: Coping Mechanism Identified in New Brain Region

Scientists at Texas A&M University have identified a region in the brain that is involved in inhibiting fear, and which could feasibly lead to...

Anti-Obesity “Biochemical Cigarette” Exploits Body’s Responses to Cold and Smoking

Researchers in Europe and Australia have developed an anti-obesity “chemical cigarette” that exploits the body’s natural responses to both cold exposure and smoking. The...

Targeting Glioblastoma by Depriving Brain Cancer Cells of Cholesterol

Study identified a metabolic vulnerability in the aggressive and incurable brain cancer glioblastoma and shown how it can potentially be exploited for therapy.

Hope for Autism Lies in Century-Old Drug

Testing a new theory, researchers have used a newly discovered function of an old drug to restore cell communications in a mouse model of autism, reversing symptoms of the disorder.

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