GENcast: 3D Cell Models Push Drug Discovery Screening into High Gear

In this GENcast, our guest will tell us more about HTS using 3D cell models and why they are so crucial for current drug discovery projects. Moreover, he will provide scientific insight into the 3D cell panel screening service—called OncoSignature™—which uses a library of 200 cell lines grown in 3D spheroids to provide a better understanding of candidate cancer therapeutics.

Impact of COVID-19 on the Life Science Industry

In this sponsored GENcast listen to a conversation with Dr. Klaus Lun, Executive Vice President of Life Science Business for Tecan, provide his perspective on global developments pertaining to COVID-19 and other timely topics.

Association Rate Constant: The Unsung Hero of Drug Discovery Kinetics

While the importance of ligand-receptor binding kinetics on drug action is becoming well established, focus to date has been almost entirely on the role of the dissociation constant on drug efficacy and duration of action. The association rate constant, in contrast, has been largely overlooked, with many investigators still considering it diffusion-limited and equivalent across a compound series. This GEN webinar aims to remedy that by turning the spotlight onto the undervalued and oft-ignored association rate constant.

The Secret to Improving the Therapeutic Index of Antibody Drug Conjugates

REGISTER NOW Broadcast Date: February 5, 2019Time: 8:00 am PT, 11:00 am ET, 17:00 CET Antibody-drug conjugates select ADCs) were initially developed to provide a selective targeting mechanism...

Self-Amplifying mRNA Vaccines for Pandemic Rapid Response

In this GEN webinar, sponsored by TriLink Biotechnologies, we will hear about data innovations from seven years of research at Novartis Vaccines on self-amplifying mRNA technology and how this approach could enable the concept of vaccines on demand as a rapid response to a real threat rather that the deployment of strategic stockpiles based on epidemiological predictions of a possible threat.

Reliable Single Cell Outgrowth: Dark Art or Science?

In this GEN webinar, we will discuss how the VIPS™ (Verified in-situ Plate Seeding) system, in combination with the SAL Scientific single-cell cloning supplements, offer customers a high-efficiency solution which ensures plates are populated with high numbers of healthy single cells that grow into resultant colonies for screening, expansion and further selection to master cell banks.

Exploring Novel Vaccine Characterization Methodologies

In this GEN webinar, we will discuss some typical workflows used to characterize the properties of vaccines, looking at properties such as particle size, surface charge, aggregation, and protein secondary structure.

Next-Gen IR Spectroscopy of Protein Structure Perturbed by Pressure

In this GEN webinar, we will review pressure-assisted protein refolding and pressure perturbation coupled with MMS to study protein stability in biopharmaceutical formulations.

The Therapeutic Antibody Screening Revolution in the Post Genomics Era

In this GEN webinar, sponsored by Carterra, we will demonstrate how modern day high-throughput surface plasmon resonance (HT-SPR™) has facilitated a paradigm shift in antibody screening, enabling higher information content assays to be conducted earlier in the research pipeline to streamline lead selection. This essentially combines screening and detailed characterization in the same step, condensing months of work into days.