Huntington’s Disease Therapy Uses the Power of Repression

A team led by researchers at Sangamo Therapeutics has shown the first, direct, demonstration of allele-selective transcriptional repression at the huntingtin locus. This opens up a novel therapeutic approach to targeting the gene responsible for Huntington's disease.

Turning Drug Delivery Inside Out

Spherical nucleic acids (SNAs) are nucleic acid sequences radially arranged on the surface of a nanoparticle. Their ability to deliver DNA and RNA to multiple types of cells and tissues has become the foundation of Exicure, a biotech company that is hoping to advance the field of genetically targeted medicines.

CBD as a Next-Gen Antibiotic

Researchers have reportedly found that cannabidiol is active against bacteria that are often responsible for many serious infections, such as Staphylococcus aureus and Streptococcus pneumoniae, with a potency similar to that of established antibiotics such as vancomycin or daptomycin. The researchers reported their findings yesterday at the annual meeting of the American Society for Microbiology in San Francisco

Type 1 Diabetes Risk Lower in Infants with Rotavirus Vaccination

Results of a cohort study of roughly 1.5 million infants found a 33% reduction in the risk of type 1 diabetes in children who received all doses of the rotavirus vaccine.

Opioid Alternative May Be Found in Lethal Pufferfish Toxin

Opioids remain a mainstay of treatment for chronic and surgical pain, despite their side effects and risk for addiction and overdose. While conventional local anesthetics block pain very effectively, they wear off quickly and can affect the heart and brain. Now, a study in rats from a group at the Boston Children’s Hospital, offers up a possible alternative, involving an otherwise lethal pufferfish toxin.

Vaccine Storage and Transport Transformed with Sugary Gel

Combining vaccines with sugars allows them to be stored and transported, removing the troublesome cold chain and enabling delivery to hard to reach areas. A multi-disciplinary team created a vaccine-storage method that suspends the vaccine in a tiny one-dose container filled with a sugar-gel combination that dries and can be reconstituted with water.

Resistance to Antibiotic of Last Resort Found in Salmonella

The discovery of mcr-9, a gene that confers resistance to colistin, adds to the growing list of plasmid-mediated colistin resistance genes that were first described in E. coli in 2015. Because colistin is one of the world's few last-resort antibiotics, mcr-9 should be immediately considered when monitoring plasmid-mediated colistin resistance.

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