Next-Gen IR Spectroscopy of Protein Structure Perturbed by Pressure

REGISTER NOW Broadcast Date: September 26, 2019 Time: 8:00 am PT, 11:00 am ET, 17:00 CET High hydrostatic pressure has been shown to act as a thermodynamic...

Zika Microcephaly Risk Linked to Mothers’ Antibodies

Scientists have started to uncover why a Zika virus infection causes microcephaly in some babies but not in others. Linking the risk of microcephaly to certain features of maternal antibodies, the research has implications for Zika virus vaccine development.

Microbiome Species that Keep Mice Lean or Obese Are Balanced by...

Researchers at University of Utah Health have shown that Clostridia bacteria in the microbiome prevent mice from becoming obese by blocking fat absorption, but only as long as they have a normal functioning immune system. In animals genetically engineered to have a lack of gut IgA, Clostridia are depleted and Desulfovibrio bacteria instead flourish and promote lipid uptake and obesity.

Zebrafish Screening Platform Boosts Spinal Cord Injury Drug Discovery

A simple drug screening platform based on a zebrafish (Danio rerio) larval spinal cord transection model shows promise to accelerate the discovery of novel therapeutics for spinal cord injury. The system can test a large number of molecules for their ability to accelerate the regeneration of the zebrafish spinal cord.

Huntington’s Disease Therapy Uses the Power of Repression

A team led by researchers at Sangamo Therapeutics has shown the first, direct, demonstration of allele-selective transcriptional repression at the huntingtin locus. This opens up a novel therapeutic approach to targeting the gene responsible for Huntington's disease.

Turning Drug Delivery Inside Out

Spherical nucleic acids (SNAs) are nucleic acid sequences radially arranged on the surface of a nanoparticle. Their ability to deliver DNA and RNA to multiple types of cells and tissues has become the foundation of Exicure, a biotech company that is hoping to advance the field of genetically targeted medicines.

CBD as a Next-Gen Antibiotic

Researchers have reportedly found that cannabidiol is active against bacteria that are often responsible for many serious infections, such as Staphylococcus aureus and Streptococcus pneumoniae, with a potency similar to that of established antibiotics such as vancomycin or daptomycin. The researchers reported their findings yesterday at the annual meeting of the American Society for Microbiology in San Francisco

Type 1 Diabetes Risk Lower in Infants with Rotavirus Vaccination

Results of a cohort study of roughly 1.5 million infants found a 33% reduction in the risk of type 1 diabetes in children who received all doses of the rotavirus vaccine.

Opioid Alternative May Be Found in Lethal Pufferfish Toxin

Opioids remain a mainstay of treatment for chronic and surgical pain, despite their side effects and risk for addiction and overdose. While conventional local anesthetics block pain very effectively, they wear off quickly and can affect the heart and brain. Now, a study in rats from a group at the Boston Children’s Hospital, offers up a possible alternative, involving an otherwise lethal pufferfish toxin.

Vaccine Storage and Transport Transformed with Sugary Gel

Combining vaccines with sugars allows them to be stored and transported, removing the troublesome cold chain and enabling delivery to hard to reach areas. A multi-disciplinary team created a vaccine-storage method that suspends the vaccine in a tiny one-dose container filled with a sugar-gel combination that dries and can be reconstituted with water.

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