The Therapeutic Antibody Screening Revolution in the Post Genomics Era

In this GEN webinar, sponsored by Carterra, we will demonstrate how modern day high-throughput surface plasmon resonance (HT-SPR™) has facilitated a paradigm shift in antibody screening, enabling higher information content assays to be conducted earlier in the research pipeline to streamline lead selection. This essentially combines screening and detailed characterization in the same step, condensing months of work into days.

Synthesis of Ginkgo Biloba Compound Opens Door to Drug Design

Researchers at the Scripps Institute have invented an efficient method for making a synthetic version of bilobalide—a natural product of the Ginkgo tree. The ability to synthesize the metabolite provides a platform to investigate its property as an insecticide or as a potential pharmaceutical.

Fungal-Derived Drugs Have Unexpected “Reaction”

Combining synthetic chemistry, genetics, enzymology, computational chemistry, and structural biology, researchers have uncovered a surprising chemical twist in how some fungal-derived compounds are made in nature. This work may be useful in designing and creating new compounds in the future.

Reliable Single Cell Outgrowth: Dark Art or Science?

REGISTER NOW Broadcast Date: October 3, 2019 Time: 8:00 am PT, 11:00 am ET, 16:00 GMT, 17:00 CET Successful cell line development (CLD) for the production of...

Next-Gen IR Spectroscopy of Protein Structure Perturbed by Pressure

REGISTER NOW Broadcast Date: September 26, 2019 Time: 8:00 am PT, 11:00 am ET, 17:00 CET High hydrostatic pressure has been shown to act as a thermodynamic...

Zika Microcephaly Risk Linked to Mothers’ Antibodies

Scientists have started to uncover why a Zika virus infection causes microcephaly in some babies but not in others. Linking the risk of microcephaly to certain features of maternal antibodies, the research has implications for Zika virus vaccine development.

Microbiome Species that Keep Mice Lean or Obese Are Balanced by...

Researchers at University of Utah Health have shown that Clostridia bacteria in the microbiome prevent mice from becoming obese by blocking fat absorption, but only as long as they have a normal functioning immune system. In animals genetically engineered to have a lack of gut IgA, Clostridia are depleted and Desulfovibrio bacteria instead flourish and promote lipid uptake and obesity.

Zebrafish Screening Platform Boosts Spinal Cord Injury Drug Discovery

A simple drug screening platform based on a zebrafish (Danio rerio) larval spinal cord transection model shows promise to accelerate the discovery of novel therapeutics for spinal cord injury. The system can test a large number of molecules for their ability to accelerate the regeneration of the zebrafish spinal cord.

Huntington’s Disease Therapy Uses the Power of Repression

A team led by researchers at Sangamo Therapeutics has shown the first, direct, demonstration of allele-selective transcriptional repression at the huntingtin locus. This opens up a novel therapeutic approach to targeting the gene responsible for Huntington's disease.

Turning Drug Delivery Inside Out

Spherical nucleic acids (SNAs) are nucleic acid sequences radially arranged on the surface of a nanoparticle. Their ability to deliver DNA and RNA to multiple types of cells and tissues has become the foundation of Exicure, a biotech company that is hoping to advance the field of genetically targeted medicines.

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