Monoclonal Antibodies

Biomanufacturing Expands Its Comfort Zone

Biomanufacturers want more flexibility, productivity, and profit. And they’ll do more to secure these gains if they feel at ease with process intensification and continuous manufacturing.
Repligen’s XCell™ ATF cell retention devices

All Roads Lead to Continuous Processing

End-to-end configurations may seem to be where continuous processing should lead, but the technology also encompasses intermediate goals such as upstream and downstream intensification.
Dendritic cell and T-lymphocytes, illustration

Automated Reproducible Dendritic Cell Production

Market-leading Corning entered into an agreement with Flaskworks to commercialize MicroDEN, an automated fluidic system that allows for differentiation of monocytes into DCs utilizing continuous perfusion of differentiation media.
Jefferson University Lab

How to Improve Your Biomanufacturing Skills

Where there’s a gap, there’s an opportunity. GEN spoke with Parviz Shamlou, PhD, from Jefferson Institute for Bioprocessing, about its 25,000 sq. ft. fully flexible state-of-the-art facility that will significantly advance the bioprocessing world.
RoosterBio scientists

Fledgling Steps toward Regenerative Medicine Superpowers

Regenerative medicine looks forward to the industrial-scale production of diverse tissues. Eventually, treatments may grant patients something like the powers of a superhero—a Salamander Man—when needed.
purple cells floating

Increasing HD-BIOP3 Seeding Efficiencies Using the VIPS™

High seeding efficiencies and improved outgrowth of clones can be achieved, says Solentim, by combining a CHO knockout cell line, the right media, and the VIPS platform.
CAR T cell cancer immunotherapy

Avalon GloboCare and GE Healthcare Partner to Advance Bioproduction for Cellular Medicines

The deal is designed to accelerate Avalon’s standardization, automation, and bioproduction for clinical-grade Chimeric Antigen Receptor (CAR)-T cells and other immune-effector cells for cellular immunotherapy, as well as exosomes/extracellular vesicles (EV) based regenerative therapeutics.
DNA and Pills

EQT Agrees to Acquire Majority Interest in CDMO Aldevron

EQT will focus on helping to advance Aldevron’s R&D and innovation efforts in genetic medicine and will also support Aldevron with investments in additional production capacity at the Fargo campus.

Pop Goes the Synthetic Cellular Control Switch

Synthetic biologists have built a modular, tunable protein switch that can sense environmental stimuli and respond by modifying cell functions such as the control of gene expression, the management of cellular traffic, the degradation of specific proteins, and the orchestration of protein-binding interactions.

Newly Discovered Bacterial Natural Product Pathway Offers Potential for Synthetic Biology

New bacterial pathway harnesses ribosomal peptide synthesis to produce a scaffold, likened to a baker's sourdough starter, and enzyme-mediated addition of amino acid and modification.

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