Viral Safety in AAV Production: How Affinity Chromatography Effectively Contributes
In this GEN webinar sponsored by Thermo Fisher Scientific, our presenters will demonstrate the efficiency of POROS CaptureSelect AAVX affinity chromatography as an effective viral clearance removal step in the downstream manufacturing of AAV for gene therapy and vaccine applications.
Super-Resolution Imaging of Chromatin Organization in Health and Disease
In this GEN webinar, sponsored by ONI, our distinguished speaker Dr. Melike Lakadamyali from the University of Pennsylvania will present her work on using super-resolution microscopy to visualize and quantify chromatin nanostructure in single cells.
The State of Gene Therapy
In the May edition of GEN Live, sponsored by Cytiva, we discuss the transformation of gene therapy from an academic endeavor to a billion-dollar biotech industry. We’ll discuss the latest research advances and hurdles, highlights from ASGCT, trends in delivery, and hear the panel’s vision for the future.
Monitoring SARS-CoV-2 Variants in Switzerland
The emergence of the SARS-CoV-2 VOC 20I/501Y.V1 (B.1.1.7 lineage) strain and its spread throughout Switzerland from the beginning of 2021 has led to an increased need for identifying the circulating SARS-CoV-2 variants. In this GEN webinar, sponsored by Tecan, the processes for identifying the presence of the VOC 20I/501Y.V1 variant in samples from the Neuchatel area will be described from the early RT-qPCR S-dropout screening to the complete viral genome sequencing.
Mapping the Pituitary Cell Atlas with Multiomics
In this GEN webinar, sponsored by 10x Genomics, we will hear about a newly developed integrated single nucleus (sn) multi-omics analysis using snap-frozen adult murine pituitaries. Moreover, our guest speaker, Dr. Frederique Ruf-Zamojski, will explain how she expanded upon her findings in mice to build single nucleus resolution atlases of gene expression and chromatin accessibility in human pituitaries from three age groups—analyzing them simultaneously by snRNA-seq and snATAC-seq.
Automated IR-Spectroscopy for Analysis of Protein Biopharmaceuticals
In this GEN webinar, sponsored by RedShiftBio, Dr. Lucy Liu of Pfizer provides an overview of the novel Microfluidic Modulation Spectroscopy (MMS) or Microfluidic Modulation IR-Spectroscopy (MM-IR) technique, an automated mid-IR spectroscopic tool for the characterization of protein secondary structure. The idea is that the MM-IR method can be widely applied in characterization and comparability.
Cell Therapy Scale-Up: Cultivation Technology Considerations
In this GEN webinar, sponsored by PHCBi, we will discuss the “other side” of cell and biologic production that doesn’t require stirred bioreactors. Furthermore, we will explore different cell expression platforms that enable various cell-based manufacturing within the small and medium-range scale of production. Finally, our webinar panelists will show us how the design of incubation systems should support both clinical and pharmaceutical applications, starting with research and leading to development, manufacturing, and scale-up.
Uncovering Leukemia Therapies with Single-Cell CRISPR Screens
In this GEN webinar, sponsored by 10x Genomics, Dr. Eric Wang from Memorial Sloan Kettering Cancer Center will speak about his recent work on using CRISPR technologies, including single-cell multimodal CRISPR screening (also known as ECCITE-seq), to discover new regulators of leukemia differentiation and potential therapeutic targets for differentiation-based therapies in AML.
