Scalable Plasmid-Free AAV Manufacturing
Sponsored by: OXGENEIn this GEN webinar, Dr. Ryan Cawood describes how rethinking AAV manufacture “from the ground up”, allowed OXGENE™ to manipulate AAV’s natural relationship with adenovirus to address these challenges with their novel technology. The webinar will take a deep dive into the data behind this new technology, demonstrating how using these vectors can give a 40-fold improvement in AAV2 yield, alongside a 2000- fold increase in particle infectivity, establishing the potential for reduced cost of goods and improved safety for AAV based gene therapies.
Traveling through Space and Time: Trajectories of Our Most Powerful Immune Cells
Sponsor: IsoPlexisImmune medicines, across cancers, infectious disease, and inflammatory disease, hold our closest promise to lasting curative therapies. In this sponsored webinar, IsoPlexis and various researchers will speak about the shift in space and time towards ‘Smaller’ to target our most powerful single cells, in order to accelerate timelines for finding these cures.
The Great Convergence: How Biology and Engineering Unite to Reshape our World
Sponsor: Horizon Discovery and OnRamp BioIn this webinar—the third in the “Women in Science” series co-hosted by GEN and the Rosalind Franklin Society—renowned neuroscientist Dr. Susan Hockfield, who served as president of MIT from 2004–2012, will share her views of the future that she lays out in her recent book, The Age of Living Machines: How Biology Will Build the Next Technology Revolution.
Biomanufacturing Assumes Central Role in Cell and Gene Therapies
Sponsor: Absorption SystemsIn this GEN Keynote webinar, Dr. Peter Marks, director of the Center for Biologics Evaluation and Research (CBER) at the FDA, will share how CBER is providing oversight to organizations during the critical developmental and manufacturing stages for biological products, as well as throughout the product life cycle.
Rapid Development of Multitagged Cell Lines for Drug Discovery
Sponsor: TecanIn this GEN webinar, sponsored by Tecan, we will discuss the development of the FAST-HDR vector system (patent pending)—a novel set of plasmids to be used in combination with CRISPR for the rapid development of multi-tagged cell lines for drug discovery. These plasmids allow the insertion of protein tags in genes of interest for downstream applications such as high-content imaging or luminescence detection on live cells. We will present examples of the use of these enhanced cellular models for high-throughput screening, target characterization, and live-cell microscopy.
Innovative Technology for Insights into Receptor Tyrosine Kinase Biology
Sponsor: Domain TherapeuticsIn this GEN webinar, our expert panelists will introduce bioSensAll™, an enhanced bystander bioluminescence resonance energy transfer (ebBRET)-based biosensor technology and its applications to interrogate RTK biology and expand current RTK drug discovery efforts.
Advances in AAV Vectors and Gene Therapy
Sponsor: AldevronIn this timely GEN Keynote webinar, sponsored by Aldevron, renowned AAV pioneer Dr. Guangping Gao (UMass Medical School/editor, Human Gene Therapy) will discuss the principles, history, challenges, and future directions of human gene therapy using AAVs. Dr. Gao will focus on progress in treating rare diseases and detail AAV capsid engineering to modulate target tissue tropism, therapeutic gene expression, and cassette design/optimization. Dr. Gao will also share examples of AAV gene therapy development: from proof-of-concept preclinical studies to first-in-human clinical evaluation.
