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University of Illinois at Chicago researchers show persistent Cas9 binding to a double strand break causes CRISPR genome editing to fail about 15 percent of the time. When RNA polymerases collide with Cas9 from one direction (template orientation)
CRISPR/Cas9

Cause of CRISPR Failure Identified and Reversed

CRISPRa-reprogrammed induced pluripotent stem cell colonies stained for pluripotency marker expression. [Otonkoski Lab/University of Helsinki]
CRISPR/Cas9

New CRISPR Approach Converts Skin Cells into Pluripotent Stem Cells

A CRISPR study has revealed that melanin pathway products regulate both the color and morphology of butterfly wing scales
CRISPR/Cas9

CRISPR-Induced Mutations Give Wing to a Butterfly Effect

The left-side group of mice is a control—with neither the gene-editing RNA nor the BOC switch. The next group has BOC but no RNA
CRISPR/Cas9

Biological Switch May Offer Better Control of Gene Editing

UT Health San Antonio scientists' used gene editing to cut DNA at a precise location to reduce autism symptoms in mice with fragile X syndrome. [University of California
CRISPR/Cas9

Editing Autism Gene with Nano-CRISPR Curbs Repetitive Behaviors

The Regents of the University of California (UC)
CRISPR/Cas9

UCal and Partners Win U.S. Patent Related to CRISPR-Cas9

Some species of Vibrio bacteria (blue) can cause cholera in humans. A version of Vibrio cholerae designed to be harmless may one day protect people against the dangerous form of the bacteria. [Tina Carvalho/University of Hawaii at Manoa/CC BY 2.0]
CRISPR/Cas9

Probiotic, Live Vaccine Both Curb Cholera

Source: NHGRI
CRISPR/Cas9

Off-the-Shelf Genome Engineering

CRISPR Cas13
CRISPR/Cas9

CRISPR Eradicates Latent HIV-1, Offering Hope of “Functional Cures”

(Left two panels) Hepatocyte-like cells (HLCs) differentiated from the stem cells of patients with hemophilia B show very low levels of clotting factor IX
CRISPR/Cas9

CRISPR “One Shot” Cell Therapy for Hemophilia Developed

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