Precision Medicine Will Rely on Proteins, Not Just DNA
From eye disease to kidney failure to cancer, protein biomarkers reveal much about disease.
Biomarker Discovery Stories
Exosomes: A Source Of Protein Biomarkers
Exosomes are 30-150 nm extracellular vesicles that are endocytically released from cells. Exosomes were previously thought to simply exude unnecessary proteins from cells; however, more recent research has highlighted their importance in cell-to-cell communication by transporting biomolecules such as mRNA, microRNA, and protein through the circulatory system.
A Comparison of Antibody Arrays and Mass Spectrometry in Protein Profiling and Biomarker Research
The protein profile reflects current cellular activity, with relevance in disease diagnosis, disease prognosis, and tracking treatment response. Studies comparing proteomic profiles of healthy and diseased patients have led to a paradigm shift in patient care for numerous types of diseases and conditions. CA125 and CA 27.29, for example, are used to monitor treatment in ovarian and breast cancer patients, respectively.
Protein Biomarker Development: Challenges and Approaches
As molecular biomarkers go, proteins are possibly the most universally affected by disease state. Protein signatures encompass not only total levels of expression, but predominance of different isoforms, cleavage products, or post-translational modifications (e.g., phosphorylation, methylation, glycosylation, ubiquitination, etc.).
Reviews Published by RayBiotech Scientists
This collection of review articles features expert content published by RayBiotech Scientists to help accelerate your biomarker discovery efforts. Cytokines in Cancer Drug Resistance: Cues to New Therapeutic Strategies Valerie Sloane Jones a,1, Ren-Yu Huang b,1, Li-PaiChen c, Zhe-Sheng Chen d Liwu Fu e, Ruo-PanHuang a, b, f Abstract - Click here...
Accelerate your biomarker discovery
The development of the biomarkers for translational medicine is a multistep process, and RayBiotech’s experts can assist you in each step of this process.
Novel Prognostic Biomarkers Discovered in Specific Cancer Types
Scientists at Cold Spring Harbor Laboratory (CSHL) have identified a specific class of biomarkers that can tell a lot about how aggressive a patient's cancer will be. "There are undoubtedly dozens or hundreds of mutations that cause cancer, and that can be found in almost any tumor," said CSHL Fellow...
Protein Biomarker Differentiates between Cystitis and Bladder Cancer
Label-free digital pathology using infrared (IR) imaging with subsequent proteomic analysis for bladder cancer (BC) has revealed the first protein biomarker (AHNAK2) for BC. AHNAK2 differentiates between chronic cystitis and a non-muscle invasive-type BC, which is challenging to diagnose. A report (“Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of...
Exosomes’ Role in Immunity May Provide Drug Delivery Target For Inhaled Bacteria
Exosomes shuttle protective antimicrobial proteins in the airway, suggesting a novel mechanism of protection against bacterial infections.
Osteoarthritis Biomarker Detected Using Nanotechnology
Scientists measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology