January 15, 2013 (Vol. 33, No. 2)


Strong Points: Concise, useful information, covers all major model systems
Weak Points: Some gene links to MGI outdated


The Wnt signaling pathway is a topic of much research, as defects in Wnt signaling result in developmental defects and have also been implicated in human diseases such as cancer. As a resource to the entire Wnt research community (as well as the curious onlooker), the Nusse laboratory at Stanford University has created a very nice resource page entitled The Wnt Homepage. Visitors to the site first encounter five blocks across the top of the page: human, mouse, fly, fish, and cancer. Selecting one of these blocks directs users to a page listing gene information for the Wnt genes in the selected species (or, in the case of the cancer page, gives an overview of Wnt signaling in the disease). Beneath the five blocks is a much more detailed site navigation table that directs visitors to pages focused on specific components of the Wnt signaling pathway (such as the frizzled and dishevelled genes). There are also sections devoted to providing information on Wnt target genes, diseases/other systems, and methods and reagents.

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