August 1, 2007 (Vol. 27, No. 14)
Strong Points: Very topical, thorough
Weak Points: None
You’ve got to like the clever title of this site. Covering large-scale protein clustering and identification of protein families, Systers is a database of considerable value for protein researchers. For example, FunctionInference is a tool for helping to identify functions of unknown proteins. Visitors simply enter database accession IDs and the program does the rest. Visitors can also browse or search for protein families using keywords, gene names, and other information. Over 7,500 phylogenetic profiles from over 19,000 Syster protein families are housed at the site and users can easily access them. Phylogenetic search options that allow one to restrict searches’ taxonomically BLASTP and BLASTX options for retrieving protein families by sequence search round out an excellent set of tools. If you’re looking for information on protein families, this is the place to look.