April 1, 2014 (Vol. 34, No. 7)
Strong Points: Easy to use, includes citations
Weak Points: None
Just thinking about this app makes me feel sick to my stomach. Bad puns aside, the InDigestion app is an easy-to-use app that provides the sequences of peptides resulting from protein digestion. Users simply search for a protein to display information (such as molecular weight and isoelectric point) for that protein. The complete amino acid sequence for the protein is also provided. Using the “digest” feature, users can then digest the protein sequence with an enzyme of their choosing. They also have the option to specify other chemical modifications or digestion constraints such as minimum or maximum mass-to-charge ratios. The resulting peptide sequences are then displayed, along with a plot of mass-to-charge ratio versus relative intensity for the peptides.