Kate Marusina, PhD, Author at GEN - Genetic Engineering and Biotechnology News

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Kate Marusina, PhD, is a writer for GEN.

Human Neurons

Age-Related Disorders

Neurodegenerative Treatments Build to a Tipping Point

At Left. A multiplexed pharmacodynamics assay was developed recently to assess immune checkpoint inhibitor–targeted CD8 activation and tumor colocalization in formalin-fixed paraffin-embedded tissues. The assay, which used oligo-conjugated antibodies supplied by Ultivue, achieved multiplex staining of CD8 (red), CD3z-pY142 (yellow), β-catenin (cyan), and Zap70-pY493 (not shown) on bead-activated CD3 cells from tissue spiked with interferon-γ-induced ACHN tumor cell lines. Staining of β-catenin allowed tumor cells to be differentiated from immune cells. Arrows point to CD8 cells that are CD3z-pY142+, indicating T-cell receptor activation.

Biomarkers

Biomarker Specialists Team Up, Run Up the Companion Diagnostics Score

Rat Lung Epithelial Cells

3D Printing

3D Bioprinting Makes the Imitation Matrix Real

Insights

Gut Microbiome: Both a Friend and a Foe

Medication

August 1 2007 Vol. 27 No. 14

Biomarkers Transform R&D