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April 27, 2010

Applied Photophysics

Stability Testing an Antibody Therapeutic in Different Formulations Using Dynamic Multi-Mode Spectroscopy (DMS)

Dynamic multimode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic in two different formulations  DMS was used to identify structural, thermodynamic and different aggregation behaviours in the different formulations The value of considering structural changes in addition to more classical Tm measurements as an indicator of stability is highlighted...

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