Label-Free Assays for High-Throughput Monoclonal Antibody Characterization

• Broadcast Date: Thursday, December 13, 2012
• Time: 2 pm ET, 11 am PT

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During therapeutic antibody development, monoclonal antibody panels are routinely screened for their binding affinities and epitope binding regions. While ELISA assays are sometimes used to perform affinity and epitope binding assays, they remain labor- and time-intensive and can produce highly variable results. Project timelines and workflows may also be adversely affected due to long ELISA assay development times.

In this webinar, industry experts will discuss their use of high-throughput, label-free assays to overcome these challenges in therapeutic antibody characterization, based on the use of the Octet® family of instruments for affinity screening and epitope binning. Details of antibody screening assay design and workflow will be presented, along with discussions of the relative strengths of different assay formats in biopharmaceutical development.

In This Webinar You Will Learn

• How the Octet platform with its label-free “Dip and Read” format enables automated screening of antibody binding characteristics
• How label-free assays are used to characterize the epitope binding regions for monoclonal antibody panels, facilitating their organization into epitope groups or “bins”
• How different strategies to optimize antibody cross-competition assays can be used
• How antibody on/off rates and affinity data are used to guide clone selection and antibody engineering studies

Who Should Attend

• Biopharma scientists developing monoclonal antibody therapeutics
• Scientists developing assays for primary antibody screening and lead identification
• Cell culture scientists assessing hybridoma antibody production
• Scientists using antibody competition assays
• Research laboratory managers
• Preclinical assay development scientists
• Lead identification
• Process development scientists
• QC/QA scientists
• Scientists performing epitope binning studies

A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists.

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