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James Wilson, M.D., Ph.D., on gene therapy as a disruptive technology

Dr. James Wilson is a professor in the department of pathology and laboratory medicine, and the director of the gene therapy program, at the University of Pennsylvania. He is also the editor of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. During this interview with GEN, Dr. Wilson discusses his concept of a disruptive technology and explains why he believes gene therapy falls into this category.

In addition to this SKYPE interview, Dr. Wilson further elaborated on his view of gene therapy as a disruptive technology in a column in the January 2012 issue of Human Gene Therapy which you can access by clicking here.

GEN videos are informative, entertaining, and encompass all aspects of biotechnology. To get details on how to submit your own, click here.



  • Biohacking—You Can Do It, Too
  • We have personal computing, so why not personal biotech? That's the question biologist Ellen Jorgensen and her colleagues asked themselves before opening Genspace, a nonprofit DIYbio lab in Brooklyn, NY, devoted to citizen science, where amateurs can go and tinker with biotechnology. Genspace offers a long list of fun, creative, and practical uses for DIYbio.

  • Life of Cells: The Common Type
  • Just like anyone striving to reach their full potential, this Jurkat cell prefers Gibco® Performance FBS. Performance FBS (Fetal Bovine Serum) from Gibco® has low endotoxin levels (≤10 EU/mL) and is ideal for general cell culture with common cell lines.

  • Why We Age—And How We Can Stop It
  • Human cells have death programmed into them. Since our cells have expiration dates, we in turn have expiration dates. Hank Green hates death, so he helps us understand the process of aging, informs us of how scientists are studying ways to prevent it, and brings us the exciting news of current research in longevity...for mice.

  • Inside Story Behind Glybera's Development and Approval
  • Late last year the European Medicines Agency granted marketing approval for the Western world's first gene therapy product, Glybera. During this SKYPE interview, James M. Wilson, M.D., Ph.D., one of the researchers who led the Glybera team, discusses the ups and downs and ins and outs of not only developing the new therapeutic but also gaining regulatory approval for the novel product. JMW is an inventor on the AAV1 patent and will receive royalties from the sales of Glybera.

  • Bioengineered Kidney Makes Urine
  • Scientists at the Massachusetts General Hospital in Boston have created a bioengineered kidney that can produce urine when transplanted into a rat’s body. This video from Nature Medicine takes a look at how growing organs in the laboratory might someday be the solution to help people with end-organ failure.

  • BIOSTAT® D-DCU
  • Experience the latest SIP fermentor generation the BIOSTAT D-DCU, designed for meeting demanding requirements in process development and production.

  • FlexMoSys™ flexible, modular and fully integrated solutions
  • The Combination of Complementary Expertise for the Next Generation of Flexible, Single-Use Manufacturing Concepts.

    Sartorius Stedim Biotech’s well-established, single-use and reusable product portfolio and G-Con Manufacturing’s novel, modular, mobile cleanroom “pods” provide an unparalleled set of cost-effective, “plug and play” tools for next-generation biomanufacturing.

  • Multiplexing Takes Research from Bench to Bedside
  • Find out how Bio-Rad’s Bio-Plex® suspension array system has contributed to research findings in Dr. Francis Spinale and Dr. Steven Kornlau's laboratories and may impact the screening and treatment of disorders like leukemia and heart disease.

  • Thermo Scientific F1-ClipTip Pipetting System
  • The F1-ClipTip pipetting system enables users to deliver consistent, reproducible pipetting with good quality results. Its ClipTip interlocking technology locks tips securely into place to deliver a tight seal on every channel. Watch this video to see it in action.

  • The CompoZr targeted integration kits
  • The CompoZr® Targeted Integration Kit-rRosa26 integrates transgenes into the Rosa26 safe harbor locus in the rat genome. CompoZr targeted integration kits employ CompoZr zinc finger nucleases (ZFNs) for precise and heritable gene knock-in, enabling straightforward creation of transgenic cell lines. This video offers background on the zinc finger nucleases in the kit.

  • 2012 BIO International Convention
  • This month, the 2012 BIO International Convention will bring together a vastly transformed global industry poised to address the monumental public health challenges facing our world today. Since our event is taking place during a time of great change for our industry, I believe this is truly a can’t-miss opportunity to connect with industry leaders to accelerate your next breakthrough. To read more from Jim Greenwood, president and CEO of the Biotechnology Industry Organization (BIO), click here.

  • James Wilson, M.D., Ph.D., on gene therapy as a disruptive technology
  • Dr. James Wilson is a professor in the department of pathology and laboratory medicine, and the director of the gene therapy program, at the University of Pennsylvania. He is also the editor of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. During this interview with GEN, Dr. Wilson discusses his concept of a disruptive technology and explains why he believes gene therapy falls into this category.

    In addition to this SKYPE interview, Dr. Wilson further elaborated on his view of gene therapy as a disruptive technology in a column in the January 2012 issue of Human Gene Therapy which you can access by clicking here.

  • Thermo Scientific KingFisher Duo
  • Achieve high yields of quality nucleic acids from a variety of starting materials. Watch our new video to see how the Thermo Scientific KingFisher Duo magnetic particle processor can help with your purification requirements.

  • Mark Heesen on Funding Challenges
  • GEN interviews Mark Heesen, president of the National Venture Capital Association, about funding challenges for the biotechnology sector. For more creative financing tips, click here.

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  • Find out why Ji-Joon Song, Ph.D., assistant professor in the department of biological sciences at the Korean Advanced Institute of Science and Technology, prefers the ChemiDoc MP. Additional details on the ChemiDoc MP can be found here.

  • Dana Carroll, Ph.D., on ZFN Technology
  • Dr. Carroll, professor at the University of Utah and one of the originators of zinc finger nuclease (ZFN) technology, reflects on the platform’s potential for genetics. To learn more about Sigma Aldrich’s ZFN technology, click here.

  • George Church, Ph.D., on Cloning a Neanderthal
  • Dr. Church, professor of genetics at Harvard Medical School and director of the Center for Computational Genetics, skypes with GEN and discusses why he thinks it is a good idea to clone a Neanderthal.

  • Hollow Fiber Modified Polyethersulfone Filters
  • Modified Polyethersulfone (mPES) is an advanced hydrophilic membrane filtration chemistry that provides higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membranes.

  • Take Your Cell Cultures to the Edge
  • See how you can maximize your culture viability with the Thermo Scientific Nunc Edge Plate! Watch the innovative evaporation buffer zone in action.

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