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Search Results - Zinc-Finger Technology
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  • Gene Editing to Treat Genetic Diseases, Part II
    The first class of these engineered molecules, zinc-finger proteins, has entered clinical ... Laval, Québec, have used TALEN technology to change the existing mutated gene ...
    6-20-2013
  • Genome 2.0: First Form, Now Function
    ... groups: the programmable nucleases (zinc finger, TAL-effector, and most recently, ... efficient in human and other mammalian cell-types). Each technology has its pros and cons. ...
    6-15-2013
  • Cocoons of Monster Silk Spun in Pilot Production Program
    negotiated a license to use Sigma Life Science's CompoZr zinc-finger nuclease (ZFN) gene-editing technology for generating genetically modified silkworms that produce spider silk. ...
    3-4-2013
  • Genome Editing for R&D and Therapeutics
    What is clear is that readily modifying human and other genomes within a wide range of cells is now a reality. ZFN Technology A pair of zinc finger nucleases (ZFNs) bound to DNA. ...
    3-1-2013
  • Sigma and Olink Partner on Protein-Protein Interaction Assay
    The technology, among other applications, can be used in combination with CompoZr® Zinc Finger Nuclease-mediated gene editing to track knocked-out or knocked-in genes and with ...
    2-12-2013
  • New Method Enables Multiplex Genome Engineering
    ... Clinical trials that use zinc-finger nucleases to cut out the gene and replace it with the normal version are now under way, and this new technology could offer an efficient ...
    1-3-2013
  • The New Economics of Orphan Diseases
    ... in February 2012 to develop therapeutics for hemophilia, Huntington's disease, and other monogenic diseases based upon Sangamo's zinc finger DNA-binding protein technology. ...
    1-1-2013
  • Measuring Drug-Transporter Interactions
    Utilizing CompoZr® zinc finger nucleases (ZFNs) from Sigma® Life Science, MDR1, BCRP, ... BCRP, and MRP2 single and double knockout Caco-2 cell lines using CompoZr ZFN technology. ...
    12-1-2012
  • Sigma Divisions Establish Screening Technology Deals
    which the latter will be able to offer its clients knockout transporter screening services utilizing Sigma's CompoZr® zinc finger nuclease technology-based drug screening assays. ...
    10-16-2012
  • Turning on Genes with The Blues
    ... The Duke researchers describe the Litez technology in a paper titled "Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors." ...
    10-2-2012
  • Accessible TALENs
    Success and failure stories associated with gene editing approaches based on zinc finger ... assessments of the success rate and targeting range of the technology remain lacking. ...
    9-20-2012
  • Honing In On Gene Delivery Targets
    ... The obligate heterodimeric protein-each monomer composed of a zinc finger DNA ... Transfecting New Genes Into the Liver AAV8, a second-generation AAV technology, was ...
    9-1-2012
  • Lighting Up Live Cells with Fluorescence
    ... an ectopic DNA molecule, they used zinc finger nucleases (ZFN) to introduce the GFP ... Ph.D., professor and PI of the Technology Center for Networks and Pathways (TCNP) ...
    9-1-2012
  • Rat Studies Reveal Unexpected Autism Gene Function
    are expected to be available in 2013. "At SAGE Labs we use CompoZr® Zinc Finger Nuclease technology to perform targeted genetic modifications in species previously not ...
    8-2-2012
  • Rat Transgene Integration
    as key components in pharmaceutical, diagnostic and other high technology manufacturing. ... CompoZr targeted integration kits employ CompoZr zinc finger nucleases (ZFNs) for precise ...
    8-1-2012

  • Journal Articles

  • Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier
    Shamim H. Rahman, Morgan L. Maeder, J. Keith Joung, Toni Cathomen
    Human Gene Therapy and Part B: Methods
    Human Gene Therapy and Part B: Methods Abstract Zinc-finger nucleases (ZFNs) are a powerful tool that can be used to edit the human genome ad libitum. The technology has ...
  • Versatile and Efficient Genome Editing in Human Cells by Combining...
    Eva-Maria Händel, Katharina Gellhaus, Kafaitullah Khan, Christien Bednarski, Tatjana I. Cornu, Felix Müller-Lerch, Robert M. Kotin, Regine Heilbronn, Toni Cathomen
    Human Gene Therapy and Part B: Methods
    Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases ... the versatility of combining the ZFN technology with a vector platform based on ...
  • Generation of Monoclonal Antibodies Specifically Directed against...
    Hugues De Rocquigny, Anne Caneparo, Chang-Zhi Dong, Thierry Delaunay, Bernard P. Roques
    AIDS Research and Human Retroviruses
    antibodies were generated with a cyclic analog of the NCp7 proximal zinc finger. ... Immunocomplex affinities were evaluated, using BIAcore technology, to be up to 1 and 10 ...

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