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Search Results - Zinc-Finger Technology
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  • HIV Researchers Seek a Potential Cure
    Sangamo's zinc finger protein (ZFP) technology, when attached to a nuclease or DNA-cutting enzyme, creates a new "designer" molecule-ZFN-that enables specific genes to be knocked ...
    10-1-2013
  • Gene Editing Typos
    linked to a nonspecific nuclease, zinc finger nuclease (ZFN) and transcription ... when constructing cell lines with this technology. *Abstract from Nature Biotechnology ...
    10-1-2013
  • Human Disease Models Move Underwater
    ... Moreover, recently developed technologies for gene editing-zinc finger nucleases (ZFNs), ... a guest lecturer. "First, gene-editing technology is enabling very elegant experiments ...
    10-1-2013
  • Sangamo Expands AAV Capabilities with Ceregene Acquisition
    proteins that the company calls zinc finger DNA-binding proteins or ZFP ... The company's first application of the technology is an autologous ZFN-CCR5-modified ...
    8-27-2013
  • Gene Editing to Treat Genetic Diseases, Part II
    The first class of these engineered molecules, zinc-finger proteins, has entered clinical ... Laval, Québec, have used TALEN technology to change the existing mutated gene ...
    6-20-2013
  • Genome 2.0: First Form, Now Function
    ... groups: the programmable nucleases (zinc finger, TAL-effector, and most recently, ... efficient in human and other mammalian cell-types). Each technology has its pros and cons. ...
    6-15-2013
  • Cocoons of Monster Silk Spun in Pilot Production Program
    negotiated a license to use Sigma Life Science's CompoZr zinc-finger nuclease (ZFN) gene-editing technology for generating genetically modified silkworms that produce spider silk. ...
    3-4-2013
  • Genome Editing for R&D and Therapeutics
    What is clear is that readily modifying human and other genomes within a wide range of cells is now a reality. ZFN Technology A pair of zinc finger nucleases (ZFNs) bound to DNA. ...
    3-1-2013
  • Sigma and Olink Partner on Protein-Protein Interaction Assay
    The technology, among other applications, can be used in combination with CompoZr® Zinc Finger Nuclease-mediated gene editing to track knocked-out or knocked-in genes and with ...
    2-12-2013
  • New Method Enables Multiplex Genome Engineering
    ... Clinical trials that use zinc-finger nucleases to cut out the gene and replace it with the normal version are now under way, and this new technology could offer an efficient ...
    1-3-2013
  • The New Economics of Orphan Diseases
    ... in February 2012 to develop therapeutics for hemophilia, Huntington's disease, and other monogenic diseases based upon Sangamo's zinc finger DNA-binding protein technology. ...
    1-1-2013
  • Measuring Drug-Transporter Interactions
    Utilizing CompoZr® zinc finger nucleases (ZFNs) from Sigma® Life Science, MDR1, BCRP, ... BCRP, and MRP2 single and double knockout Caco-2 cell lines using CompoZr ZFN technology. ...
    12-1-2012
  • Sigma Divisions Establish Screening Technology Deals
    which the latter will be able to offer its clients knockout transporter screening services utilizing Sigma's CompoZr® zinc finger nuclease technology-based drug screening assays. ...
    10-16-2012
  • Turning on Genes with The Blues
    ... The Duke researchers describe the Litez technology in a paper titled "Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors." ...
    10-2-2012
  • Accessible TALENs
    Success and failure stories associated with gene editing approaches based on zinc finger ... assessments of the success rate and targeting range of the technology remain lacking. ...
    9-20-2012

  • Journal Articles

  • Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier
    Shamim H. Rahman, Morgan L. Maeder, J. Keith Joung, Toni Cathomen
    Human Gene Therapy and Part B: Methods
    Human Gene Therapy and Part B: Methods Abstract Zinc-finger nucleases (ZFNs) are a powerful tool that can be used to edit the human genome ad libitum. The technology has ...
  • Versatile and Efficient Genome Editing in Human Cells by Combining...
    Eva-Maria Händel, Katharina Gellhaus, Kafaitullah Khan, Christien Bednarski, Tatjana I. Cornu, Felix Müller-Lerch, Robert M. Kotin, Regine Heilbronn, Toni Cathomen
    Human Gene Therapy and Part B: Methods
    Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases ... the versatility of combining the ZFN technology with a vector platform based on ...
  • Generation of Monoclonal Antibodies Specifically Directed against...
    Hugues De Rocquigny, Anne Caneparo, Chang-Zhi Dong, Thierry Delaunay, Bernard P. Roques
    AIDS Research and Human Retroviruses
    antibodies were generated with a cyclic analog of the NCp7 proximal zinc finger. ... Immunocomplex affinities were evaluated, using BIAcore technology, to be up to 1 and 10 ...

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