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Search Results - Zinc Finger Nucleases
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  • Gene Editing to Treat Genetic Diseases, Part II
    zinc-finger proteins, has entered clinical trials for treatment of diabetic neuropathy, AIDS, and glioblastoma. Most recently, transcription activator-like effector nucleases ...
    6-20-2013
  • Genome 2.0: First Form, Now Function
    ... But what are the techniques available now and what can they do? Genome editing techniques broadly fall into two groups: the programmable nucleases (zinc finger, TAL-effector, and ...
    6-15-2013
  • Genetic Bug Spray? Scientists Alter Mosquitoes' Sense of Smell
    Dr. Vosshall and her colleagues used zinc-finger nucleases to specifically mutate their target, the gene orco, in mosquito embryos. "We knew this gene was important for flies to be ...
    5-30-2013
  • Genome Editing for R&D and Therapeutics
    What is clear is that readily modifying human and other genomes within a wide range of cells is now a reality. ZFN Technology A pair of zinc finger nucleases (ZFNs) bound to DNA. ...
    3-1-2013
  • Footprint-Free, Site-Specific Gene Editing
    The synthetic, site-specific double-stranded nucleases, primarily the TALENs and ZFNs (TAL effector nucleases and zinc finger nucleases), can significantly increase the frequency ...
    3-1-2013
  • New Method Enables Multiplex Genome Engineering
    ... Clinical trials that use zinc-finger nucleases to cut out the gene and replace it with the normal version are now under way, and this new technology could offer an efficient ...
    1-3-2013
  • Measuring Drug-Transporter Interactions
    Utilizing CompoZr® zinc finger nucleases (ZFNs) from Sigma® Life Science, MDR1, BCRP, and MRP2 efflux transporter genes were targeted for ZFN-mediated knockout in a Caco-2 cell ...
    12-1-2012
  • Animal Models Get Closer to Mimicking Humans
    ... SAGE Labs reportedly opened new opportunities for drug development by creating rat knockout (KO) models using zinc finger nucleases (ZFNs). ZFNs recognize and cut specific DNA ...
    10-1-2012
  • Accessible TALENs
    Success and failure stories associated with gene editing approaches based on zinc finger nucleases and transcription activator-like effector nucleases (TALENs) have been making ...
    9-20-2012
  • Someone's in the Kitchen With DNA: A Biotech Thanksgiving
    When the function isn't known to exist in nature, using natural components as raw materials is a good start-zinc finger nucleases, made from joining DNA-binding zinc fingers to a ...
    9-4-2012
  • Synthetic Biology-From Black Box to Toolbox
    ... Sangamo presented positive Phase I results last month and is working on a similar method to treat stem cells. Zinc-finger nucleases (ZFN) have room for improvement, though; use of ...
    9-4-2012
  • Lighting Up Live Cells with Fluorescence
    ... Instead of introducing the genes encoding the fluorescent protein fusions through an ectopic DNA molecule, they used zinc finger nucleases (ZFN) to introduce the GFP genes directly ...
    9-1-2012
  • The CompoZr targeted integration kits
    CompoZr targeted integration kits employ CompoZr zinc finger nucleases (ZFNs) for precise and heritable gene knock-in, enabling straightforward creation of transgenic cell lines. ...
    8-13-2012
  • Rat Transgene Integration
    CompoZr targeted integration kits employ CompoZr zinc finger nucleases (ZFNs) for precise and heritable gene knock-in, enabling straightforward creation of transgenic cell lines. ...
    8-1-2012
  • Naked ZFNs Point to More Efficient, Safer Gene Therapy
    Researchers have made the surprising discovery that DNA-cutting zinc finger nucleases (ZFNs) can directly penetrate into cells and don't need to be delivered as DNA constructs ...
    7-2-2012
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    Journal Articles

  • Evaluating the Mutagenic Activity of Targeted Endonucleases Containing...
    Laura M. Pillay, Lyndsay G. Selland, Valerie C. Fleisch, Patricia L.A. Leighton, Caroline S. Cheng, Jakub K. Famulski, R. Gary Ritzel, Lindsey D. March, Hao Wang, W. Ted Allison, Andrew J. Waskiewicz
    Zebrafish
    Zebrafish Synthetic targeted endonucleases such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have recently emerged as powerful tools ...
  • Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease...
    Dawn A. Maier, Andrea L. Brennan, Shuguang Jiang, Gwendolyn K. Binder-Scholl, Gary Lee, Gabriela Plesa, Zhaohui Zheng, Julio Cotte, Carmine Carpenito, Travis Wood, S. Kaye Spratt, Dale Ando, Philip Gregory, Michael C. Holmes, Elena. E. Perez, James L. Riley, Richard G. Carroll, Carl H. June, Bruce L. Levine
    Human Gene Therapy and Part B: Methods
    Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease-Targeted Disruption of ... Treatment of CD4+ T cells with zinc-finger protein nucleases (ZFNs) specifically ...
  • Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier
    Shamim H. Rahman, Morgan L. Maeder, J. Keith Joung, Toni Cathomen
    Human Gene Therapy and Part B: Methods
    Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier Human Gene Therapy and Part B: Methods Abstract Zinc-finger nucleases (ZFNs) are a powerful tool that can be used ...
  • Synthetic Zinc Finger Nuclease Design and Rapid Assembly
    Mark J. Osborn, Anthony P. DeFeo, Bruce R. Blazar, Jakub Tolar
    Human Gene Therapy and Part B: Methods
    Synthetic Zinc Finger Nuclease Design and Rapid Assembly Human Gene Therapy and Part B: Methods Abstract Engineered zinc finger nucleases (ZFNs) are a tool for genome manipulation ...

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