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  • Separation of Therapeutic Biomolecules
    ... protein and double-stranded DNA removal, and were suitable for use in production scaleup. ... The presentation included a description of a flow-through purification of influenza virus ...
    5-1-2013
  • Boosting Downstream Productivity
    ... Filters must be optimized to achieve the highest throughput without compromising the flow rate, and the desired log retention value for virus removal. The virus filter, or ...
    4-15-2013
  • Virus Removal
    The company works with virus filtration products, with its Planova virus removal filters having been used in the production of biotherapeutics for over 20 years. Designed for ...
    4-15-2013
  • Betting on Baculovirus Expression
    ... proteins are made and assembled into VLPs as individual vaccines for each strain of virus. ... had an endotoxin level of 0.7 EU/mg without utilizing endotoxin removal techniques. ...
    3-15-2013
  • Better Filtration Merges Innovation & Need
    Note the distinction between this form of virus removal, and late-stage filtration undertaken mainly for patient safety. "The question is, can we remove/inactivate viruses early in ...
    3-1-2013
  • Chromatography Media
    The company works with virus filtration products, with its Planova virus removal filters having been used in the production of biotherapeutics for over 20 years. TechniPur(tm) 40 ...
    2-15-2013
  • Tackling Transfection Tasks
    ... an experimental setting, a West Nile Virus DNA vaccine that has been used to protect ... vp North America for BIA Separations. "Removal of endotoxins and genomic DNA is commonly ...
    1-1-2013
  • Inventive Approaches Redefine Downstream Ops
    ... Faro, "It permits efficient removal of both enveloped and nonenveloped viruses, and we ... Proteins filtered through the small virus retentive filter membranes include thrombin, ...
    12-1-2012
  • CMOs Focus on Technology Improvements
    ... the efficiency and effectiveness of process-based impurity removal such as virus and DNA removal, but in the future, may also impact specific product based impurity removal." ...
    10-1-2012
  • Advertorial: Asahi Kasei Bioprocess
    Downstream Bioprocessing Industry Leader Backed by Planova(tm) Virus-Removal Filters Asahi Kasei Bioprocess (AKB) provides pharmaceutical and biopharmaceutical manufacturers with a ...
    10-1-2012
  • Virus Preparation for Filter Validation
    In a scaled-down study, a sample of representative process feed is "spiked" with a known quantity of virus to simulate a viral contamination. Virus removal and hydraulic ...
    8-1-2012
  • Taming Difficult to Express Proteins
    For example, viral clearance is not required at the preclinical stage, so virus removal and inactivation are not explored. "With the goal of simply making enough protein ...
    6-15-2012
  • New Approaches Redefine Small Molecule Discovery
    ... HDACs catalyze the removal of acetyl groups from nucleosomal histones, to convert ... to the inhibition of the hepatitis C virus (HCV). "There are several key challenges ...
    6-15-2012
  • Removing Impurities from Biotherapeutics
    ... Compared to membranes A and B in Figure 5 , QSD demonstrated a much higher capacity for virus removal. QSD showed complete PPV clearance out to 1,250 membrane volumes (12.5 kg ...
    3-15-2012
  • EMD Millipore, Charles River Laboratories Ally for Improved Viral...
    purity virus preparations. This in turn is expected to help ensure validation success and regulatory compliance for biopharmaceutical manufacturers. TrueSpike enables removal of ...
    2-27-2012
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    Journal Articles

  • Percutaneous Endoscopic Gastrostomy Placement in a Human Immunodeficie...
    Ramesh M. Nataraja, Julia R. Fishman, Aisha Naseer, Jo Dodge, Sam M.D. Walters, Simon A. Clarke, Munther J. Haddad
    Journal of Laparoendoscopic& Advanced Surgical Techniquesand Part B, Videoscopy
    Percutaneous Endoscopic Gastrostomy Placement in a Human Immunodeficiency Virus-Positive ... Parameters examined included infections, leakage, displacement, reasons for removal, total ...
  • Cytokine-Activated Natural Killer Cells Exert Direct Killing...
    Jonathan Larkin, Anne Bost, John I. Glass, Seng-Lai Tan
    Journal of Interferon & Cytokine Research
    It has been suggested that this phenotype is a result of virus-specific defects in ... In contrast, on removal of cytokine stimulation, NK cells failed to exert any direct ...
  • Overexpression of SERCA1a in the mdx Diaphragm Reduces Susceptibility...
    Kevin J. Morine, Meg M. Sleeper, Elisabeth R. Barton, H. Lee Sweeney
    Human Gene Therapy and Part B: Methods
    Neonatal adeno-associated virus gene transfer of sarcoplasmic reticulum ATPase 1a to the ... investigation of therapeutic strategies aimed at enhanced cytosolic calcium removal.
  • Interleukin-28 and Interleukin-29: Novel Regulators of Skin Biology
    Kerstin Wolk, Katrin Witte, Robert Sabat
    Journal of Interferon & Cytokine Research
    .../antiviral defense, wound healing, and removal of tumors, are regulated by cytokines. ... In the skin, IL-28 and IL-29 can be produced by virus-infected cells, maturing dendritic ...

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