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  • Companion Diagnostics: 52 Pick-Up
    On the diagnostics side, Roche inked earlier deals with Merck, Clovis Oncology, and Transgene. Approved companion diagnostics are listed by name, sponsor-developer, and a summary ...
    5-9-2013
  • Is This Gene Therapy's Breakout Moment?
    ... factor IX (FIX) transgene. The treatment resulted in FIX transgene expression at levels sufficient to improve the bleeding phenotype, with few side effects, all easily treatable. ...
    4-1-2013
  • Novel Platform for Immunotherapies Created
    Sanofi and Transgene inked a collaboration agreement for the creation of a new industrial ... an investment amount of $12.9 million dollars, equally financed by Sanofi and Transgene. ...
    3-26-2013
  • Is This Gene Therapy's Breakout Moment?
    ... factor IX (FIX) transgene. The treatment resulted in FIX transgene expression at levels sufficient to improve the bleeding phenotype with few side effects, all easily treatable. ...
    3-4-2013
  • Accelerate Cell-Line Development
    UCOE expression vectors contain the DNA sequences of housekeeping genes that increase transgene expression in eukaryotic cells by remodeling the surrounding chromatin, inducing a ...
    2-1-2013
  • Breast Cancer Suppressing Enzyme Could Reverse Obesity
    Stat3 mediates the expression of a variety of genes that regulate a host of cellular processes. Tyk2-negative mice expressing CAStat3 transgene in brown fat also show improved BAT ...
    12-6-2012
  • Cell-Line Customization Service
    Gene customization experts can modify cell lines at any gene, at any position. Services available include gene modification, knock-out, and targeted transgene integration. Thirteen ...
    11-15-2012
  • Intrexon to Take 48% Stake in Aquaculture Firm
    The firm's technologies are underpinned by its Ultravector(tm) transgene platform. "This transaction will accelerate our efforts to play a leading role in solving the world's ...
    11-1-2012
  • Honing In On Gene Delivery Targets
    The decision of how to put a transgene into a cell depends as much on the concerns about ... Will the vector be able to find and enter its desired target? Will the transgene insert ...
    9-1-2012
  • Inducible Switch Controls Transgene Expression in Viruses
    of the engineered virus adjacent to the transgene gene, such that both switch and target ... Its design effectively kept expression of the transgene off in the presence of the ...
    8-22-2012
  • Rat Studies Reveal Unexpected Autism Gene Function
    in species previously not amenable to such modifications, be it gene knockout, transgene insertion, point mutations, or conditional gene knockout," says Edward Weinstein, ...
    8-2-2012
  • Rat Transgene Integration
    enabling straightforward creation of transgenic cell lines. Kits include the ZFNs and donor plasmid to perform transgene integration by ZFN-assisted homologous recombination.
    8-1-2012
  • Symbiotic Bacteria Halt Malaria Life Cycle in Mosquitoes
    ... Should the technical barriers for transgene introgression into mosquito populations be solved, we envision the concomitant application of both strategies (genetically modified ...
    7-17-2012
  • Antisense Oligos Reverse Huntington Disease Phenotype in Mice
    ... a full-length mutant human huntingtin transgene (including the human huntingtin ... Infusion an ASO designed to target the mutant R6/2 transgene (HuASO Ex1 ) into the right ...
    6-21-2012
  • Personalized Medicine Toolbox Expands
    ... or large gene deletions, point-mutations, reversion of mutations to wild type, translocations, amplifications, and transgene insertions), with unparalleled precision ( Figure 1 ). ...
    6-1-2012
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    Journal Articles

  • Comparison of Viral and Nonviral Vectors for Gene Transfer to...
    Brian Kealy, Aaron Liew, Jill M. McMahon, Thomas Ritter, Aideen O'Doherty, Melissa Hoare, Udo Greiser, Erin E. Vaughan, Martin Maenz, Ciara O'Shea, Frank Barry, Timothy O'Brien
    Tissue Engineering, Part C: Methods
    The efficacy of this approach depends on the efficiency of the vector used for transgene delivery. Methods/Results: In this study, we have compared the efficiency of adenovirus, ...
  • Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive...
    Gemma E. Rooney, Siobhan S. McMahon, Thomas Ritter, Yolanda Garcia, Cathal Moran, Nicolas N. Madigan, Alexander Flügel, Peter Dockery, Timothy O'Brien, Linda Howard, Anthony J. Windebank, Frank P. Barry
    Tissue Engineering, Part A
    GDNF-transduced MSCs expressed the transgene and secreted growth factor into the media (~12?ng/500,000 cells secreted into the supernatant 2 weeks after transduction). Injuries ...
  • Establishment of a Cell Line Derived from a Mouse Fetal Liver...
    Iwao Ikai, Shinji Uemoto, Ken Fukumitsu, Takamichi Ishii, Kentaro Yasuchika, Yuji Amagai, Miho Kawamura-Saito, Tatsuya Kawamoto, Eihachiro Kawase, Hirofumi Suemori, Norio Nakatsuji
    Tissue Engineering, Part A
    The present study established a murine fetal liver stromal cell line that induced hepatic maturation in mouse ESCs and HPCs. A transgene containing a temperature-sensitive SV40 ...
  • Enhanced In Vitro Chondrogenesis of Primary Mesenchymal Stem...
    Andre F. Steinert, Glyn D. Palmer, Carmencita Pilapil, Ulrich Nöth, Christopher H. Evans, Steven C. Ghivizzani
    Tissue Engineering, Part A
    Levels of transgene product in the medium were initially high, approximately 100?ng/mL ... greater expression of cartilage-specific marker genes than with either transgene alone. ...

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