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  • Companion Diagnostics: 52 Pick-Up
    On the diagnostics side, Roche inked earlier deals with Merck, Clovis Oncology, and Transgene. Approved companion diagnostics are listed by name, sponsor-developer, and a summary ...
    5-9-2013
  • Is This Gene Therapy's Breakout Moment?
    ... factor IX (FIX) transgene. The treatment resulted in FIX transgene expression at levels sufficient to improve the bleeding phenotype, with few side effects, all easily treatable. ...
    4-1-2013
  • Novel Platform for Immunotherapies Created
    Sanofi and Transgene inked a collaboration agreement for the creation of a new industrial ... an investment amount of $12.9 million dollars, equally financed by Sanofi and Transgene. ...
    3-26-2013
  • Is This Gene Therapy's Breakout Moment?
    ... factor IX (FIX) transgene. The treatment resulted in FIX transgene expression at levels sufficient to improve the bleeding phenotype with few side effects, all easily treatable. ...
    3-4-2013
  • Accelerate Cell-Line Development
    UCOE expression vectors contain the DNA sequences of housekeeping genes that increase transgene expression in eukaryotic cells by remodeling the surrounding chromatin, inducing a ...
    2-1-2013
  • Breast Cancer Suppressing Enzyme Could Reverse Obesity
    Stat3 mediates the expression of a variety of genes that regulate a host of cellular processes. Tyk2-negative mice expressing CAStat3 transgene in brown fat also show improved BAT ...
    12-6-2012
  • Cell-Line Customization Service
    Gene customization experts can modify cell lines at any gene, at any position. Services available include gene modification, knock-out, and targeted transgene integration. Thirteen ...
    11-15-2012
  • Intrexon to Take 48% Stake in Aquaculture Firm
    The firm's technologies are underpinned by its Ultravector(tm) transgene platform. "This transaction will accelerate our efforts to play a leading role in solving the world's ...
    11-1-2012
  • Honing In On Gene Delivery Targets
    The decision of how to put a transgene into a cell depends as much on the concerns about ... Will the vector be able to find and enter its desired target? Will the transgene insert ...
    9-1-2012
  • Inducible Switch Controls Transgene Expression in Viruses
    of the engineered virus adjacent to the transgene gene, such that both switch and target ... Its design effectively kept expression of the transgene off in the presence of the ...
    8-22-2012
  • Rat Studies Reveal Unexpected Autism Gene Function
    in species previously not amenable to such modifications, be it gene knockout, transgene insertion, point mutations, or conditional gene knockout," says Edward Weinstein, ...
    8-2-2012
  • Symbiotic Bacteria Halt Malaria Life Cycle in Mosquitoes
    ... Should the technical barriers for transgene introgression into mosquito populations be solved, we envision the concomitant application of both strategies (genetically modified ...
    7-17-2012
  • Antisense Oligos Reverse Huntington Disease Phenotype in Mice
    ... a full-length mutant human huntingtin transgene (including the human huntingtin ... Infusion an ASO designed to target the mutant R6/2 transgene (HuASO Ex1 ) into the right ...
    6-21-2012
  • Personalized Medicine Toolbox Expands
    ... or large gene deletions, point-mutations, reversion of mutations to wild type, translocations, amplifications, and transgene insertions), with unparalleled precision ( Figure 1 ). ...
    6-1-2012
  • Synthetic Biology Defined by Interdisciplinarity
    ... Fussenegger and colleagues subsequently illustrated its use in a mouse model, where it enabled the light-induced expression of a transgene. In a type 2 diabetes mouse model ...
    5-15-2012
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    Journal Articles

  • Transgene Expression After Rep-Mediated Site-Specific Integration...
    Nicola J. Philpott, Janette Gomos, Erik Falck-Pedersen
    Human Gene Therapy and Part B: Methods
    Transgene Expression After Rep-Mediated Site-Specific Integration into Chromosome 19 Human ... of a site-specifically integrated transgene (either green fluorescent protein [GFP] ...
  • Transgene Expression up to 7 years in Nonhuman Primates Following...
    Nicola Brunetti-Pierri, Thomas Ng, David Iannitti, William Cioffi, Gary Stapleton, Mark Law, John Breinholt, Donna Palmer, Nathan Grove, Karen Rice, Casssondra Bauer, Milton Finegold, Arthur Beaudet, Charles Mullins, Philip Ng
    Human Gene Therapy and Part B: Methods
    Transgene Expression up to 7 years in Nonhuman Primates Following Hepatic Transduction ... longer duration of transgene expression compared to first generation adenoviral vectors. ...
  • Stable Transgene Expression in Primitive Human CD34 + Hematopoietic...
    Teiko Sumiyoshi, Nathalia G. Holt, Roger P. Hollis, Shundi Ge, Paula M. Cannon, Gay M. Crooks, Donald B. Kohn
    Human Gene Therapy and Part B: Methods
    Stable Transgene Expression in Primitive Human CD34 + Hematopoietic Stem/Progenitor Cells, ... has been shown to achieve long-term transgene expression in a wide range of host cells. ...
  • Transgene Loss and Changes in the Promoter Methylation Status...
    Jörg Schüttrumpf, Peter Milanov, Daniela Abriss, Stefanie Roth, Torsten Tonn, Erhard Seifried
    Human Gene Therapy and Part B: Methods
    Transgene Loss and Changes in the Promoter Methylation Status as Determinants for ... of normal) FIX was fully functional. Transgene loss was the main determinant for ...

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