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Search Results - Toxicity
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  • Molecular Imaging Driving Development
    High-Throughput Toxicity Screening Scanning electron micrograph of a cardiac cell grown on ... said that despite successful preclinical studies, drugs often show dose-related toxicity. ...
    8-1-2013
  • M&A Doubleheader: Two Ailing Companies Bought Out
    for Menadione Topical Lotion (a Phase II product for the treatment of the skin toxicity associated with epidermal growth-factor receptor anticancer agents such as Erbitux®). ...
    7-17-2013
  • Rexahn Licenses University of Maryland Cancer Drug Delivery Platform
    studies showed increased efficacy and reduced toxicity compared with docetaxel alone. ... in the blood, where the chemo agent's toxicity to all cells has linked it with high ...
    7-17-2013
  • EU Commits $4.5B Over 10 Years for Drug Research
    new drug-toxicity prediction models; a new severe-asthma definition; the world's largest database of schizophrenia studies; and research into the mechanisms of chronic pain. ...
    7-11-2013
  • Closer-to-Real 3D Cell Culture Advances
    The company is developing an artificial 3D skin construct for cosmetic and topical drug testing, a liver toxicity assay using 3D cultured hepatocytes, a 3D platform for enhanced ...
    7-3-2013
  • Unraveling the Transcriptome
    ... opportunity to examine chemical carcinogenesis under conditions that mimic chronic, low-dose human toxicity. "This is a reasonable surrogate for human exposure," says Dr. Merrick. ...
    7-1-2013
  • Improving Molecular Distribution Analysis
    Heat Stabilization Overcomes Major Limitation of Mass Spec Imaging in Distribution Studies Accumulation and reservoirs, clearance and degradation, toxicity and dosage are highly ...
    7-1-2013
  • Assay Development Driving Personalized Medicine
    ... "If you are applying a biomarker to determine if a patient has a better outcome, less toxicity, or a better quality of life, that is different than asking about the observed ...
    7-1-2013
  • High-Content Screening for Identifying miRNAs Inducing Cardiac...
    safety testing of pharmacologic compounds, especially in determining chronotropic and toxicity effects prior to clinical studies Who Should Attend Drug Development Scientists ...
    6-25-2013
  • HIV-Derived Antibacterial Compounds Could Help Fight Multidrug...
    membranes, we thought that these similar peptide sequences in the HIV envelope protein might contribute to toxicity and death in infected cells by altering cell membranes." ...
    6-20-2013
  • Dual Live-Cell Imaging Now Possible
    Silica-coated AuNRs reduced toxicity compared to bare AuNRs. Cultivating cells may take ... Cell proliferation and death measurement is a basic function in drug toxicity and safety ...
    6-15-2013
  • Nudging Difficult-to-Express Proteins Along
    Overcoming toxicity and poor accumulation are common themes in many unsuccessful attempts ... associate in antibody engineering, toxicity can be suppressed and cell growth ...
    6-15-2013
  • NeuroVive, Isomerase Team Up to Study Cyclophilin Inhibitor
    Specifically, it optimizes microbial natural products in order to improve various properties, including selectivity, reducing toxicity, improving ADME profile, altering route of ...
    6-13-2013
  • FDA Rejects Aveo's Tivozanib for RCC; Rips Phase III Results
    Nexavar showed a better overall-survival rate. "Tivozanib has greater delayed toxicity or toxicity not recognized," FDA posited in a hypothesis during a presentation by Amna ...
    6-10-2013
  • Strategies to Optimize Cell Culture
    ... using our 3D system to evaluate bioprocessing of micro- and nanomaterials. "We have measured binding and internalization of these materials as well as toxicity of nanomaterials. ...
    6-1-2013
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    Journal Articles

  • Safety and Efficacy of a Genetic Vaccine targeting Telomerase...
    Alessandra Gavazza, George Lubas, Arthur Fridman, Daniela Peruzzi, Joseph A Impellizeri, Laura Luberto, Emanuele Marra, Giuseppe Roscilli, Gennaro Ciliberto, Luigi Aurisicchio
    Human Gene Therapy and Part B: Methods
    The immune response was measured by ELISPOT. The expression of dTERT was quantified by quantitative PCR. Changes in hematological parameters, local/systemic toxicity or organic ...
  • Transgene Expression up to 7 years in Nonhuman Primates Following...
    Nicola Brunetti-Pierri, Thomas Ng, David Iannitti, William Cioffi, Gary Stapleton, Mark Law, John Breinholt, Donna Palmer, Nathan Grove, Karen Rice, Casssondra Bauer, Milton Finegold, Arthur Beaudet, Charles Mullins, Philip Ng
    Human Gene Therapy and Part B: Methods
    Because duration of transgene expression and long-term toxicity are critical for risk:benefit assessment, we have continued to monitor these animals. We report here that transgene ...
  • In Vivo Toxicity, Pharmacokinetic Features, and Immunogenicity...
    DOROTHEA E. MYERS, FATIH M. UCKUN
    Journal of Medicinal Food
    In Vivo Toxicity, Pharmacokinetic Features, and Immunogenicity of B43(Anti-CD19)-Genistein Immunoconjugate in Mice and Non-human Primates Journal of Medicinal Food
  • Comparative Study of the Efficacy of Ascorbic Acid, Quercetin...
    Vidhya Ambadath, Renju Gopal Venu, Indira Madambath
    Journal of Medicinal Food
    Comparative Study of the Efficacy of Ascorbic Acid, Quercetin, and Thiamine for Reversing Ethanol-Induced Toxicity Journal of Medicinal Food

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