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  • Deciphering RNA Secondary Structure
    ... Their size allows enhanced permeability and retention effects that minimize off-target effects or toxicity." According to Dr. Guo, active delivery of RNA nanoparticles can be ...
    10-15-2013
  • Toxicity Screens with Increased Insight
    Unpredicted side-effects and toxicity issues limit or prevent a candidate molecule being ... are of low throughput and will not capture the complexity involved in cellular toxicity. ...
    10-15-2013
  • Biological Pathway Identified Linking Diabetes and Heart Disease
    ... cardiovascular disease and, potentially, therapeutics for glucose toxicity in other tissues that are affected by diabetes such as the retina, the nervous system, and the kidney." ...
    10-1-2013
  • Probing Watery Films to Reveal Contours of Membrane Proteins
    ... The working hypothesis is that at some aggregation stages, tau may exert toxicity as it breaks through the membrane barrier, in part determined by its slowed surface water ...
    10-1-2013
  • PMT-Based Hit Picking for HCA
    hits from a primary HTS screen, target discovery (i.e., RNAi screening) or lead optimization (i.e., toxicity) applications where the compound number screened is relatively small. ...
    10-1-2013
  • Advertorial: Corning Life Sciences
    ... Cells grown in traditional media supplemented with L-glutamine are susceptible to toxicity... ammonia during storage and incubation, minimizing toxicity and improving culture quality. ...
    10-1-2013
  • Striking Solid Tumors: Transporting Treatments Safely and Effectively
    ... That said, broad acceptance of SBRT by radiation oncologists has been hampered by concerns of toxicity from the very potent, focused beams of radiation delivered to extracranial ...
    9-23-2013
  • Cutting Melanoma Off at the Pass
    ... toxic at the same time. "We followed these mice with melanoma for three weeks, tumors remain stable, and mice did not show any evident signs of toxicity," noted Dr. Villanueva. ...
    9-20-2013
  • BARDA Exercises $6M Option for Aeolus' Acute Radiation Syndrome...
    preparatory work for additional human clinical studies including PK/PD ADME and toxicity studies, additional murine efficacy trials including duration of treatment and ...
    9-18-2013
  • Cell-Based Assays: Getting Back to Basics
    ... Stem Cells and Toxicity Testing Spontaneously contractile Cytiva(tm) Cardiomyocytes enable ... Cardiotoxicity is frequently the chief culprit. "Although toxicity testing often involves ...
    9-15-2013
  • Novel 3D Cell Culture Systems
    To predict drug response or toxicity, the pharmaceutical industry is increasingly ... community for testing the safety, toxicity, and efficacy of drug compounds in in ...
    9-15-2013
  • New Report Lays Out Guidelines to Improve Cancer Care
    ... in those age-appropriate and comorbid-appropriate populations, and to demonstrate both its efficacy and toxicity in that setting," Dr. Ganz said. "We think that's an opportunity. ...
    9-10-2013
  • Chemists Find New Way to Put the Brakes on Cancer
    Importantly, the compound did not show any signs of toxicity or negative impact in the test host. The investigators noted that the blockade of gene expression was selective: "Gene ...
    9-9-2013
  • Transfection Methods Evolving
    ... Typically, cationic liposomal reagents have high cellular toxicity; in contrast, newer ... Achieving a balance of efficient transfection with low toxicity is the universal ...
    9-1-2013
  • Multiparametric Assays for Cardiomyocytes
    ... To obtain additional information on possible toxicity of compounds that caused a decrease ... Changes in cell viability due to compound toxicity were analyzed using the cell ...
    9-1-2013
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    Journal Articles

  • Toxicity and Biodistribution of a First-Generation Recombinant...
    Changyu Zheng, Corinne M. Goldsmith, Fumi Mineshiba, John A. Chiorini, Andrew Kerr, Martin L. Wenk, Molly Vallant, Richard D. Irwin, Bruce J. Baum
    Human Gene Therapy and Part B: Methods
    Toxicity and Biodistribution of a First-Generation Recombinant Adenoviral Vector, Encoding ... glands, we have conducted a detailed toxicity and biodistribution study in adult rats. ...
  • Acute Toxicity After High-Dose Systemic Injection of Helper-Dependent...
    Nicola Brunetti-Pierri, Donna J. Palmer, Arthur L. Beaudet, K. Dee Carey, Milton Finegold, Philip Ng
    Human Gene Therapy and Part B: Methods
    Acute Toxicity After High-Dose Systemic Injection of Helper-Dependent Adenoviral Vectors ... can provide sustained, high-level transgene expression with negligible long-term toxicity. ...
  • Toxicity of High-Dose Intravitreal Adalimumab (Humira) in the...
    Roberta P.A. Manzano, Gholam A. Peyman, Petros E. Carvounis, Francisco Max Damico, Renata Genaro Aguiar, Gabriela L. Ioshimoto, Dora Fix Ventura, Sylvia T. Cursino, Walter Takahashi
    Journal of Ocular Pharmacology and Therapeutics
    Toxicity of High-Dose Intravitreal Adalimumab (Humira) in the Rabbit Journal of Ocular Pharmacology and Therapeutics Abstract Purpose: To evaluate the ocular toxicity of escalating ...
  • Comparative Toxicity of Preservatives on Immortalized Corneal...
    Seth P. Epstein, Michael Ahdoot, Edward Marcus, Penny A. Asbell
    Journal of Ocular Pharmacology and Therapeutics
    Comparative Toxicity of Preservatives on Immortalized Corneal and Conjunctival Epithelial ... These components can add to the toxicity of eye drops and cause ocular surface disease. To ...

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