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  • Seasoned Drugs Offer Therapeutic Gold Mine
    Because the approved drugs have already been tested in humans, repositioning a drug saves time. Important information such as toxicity, pharmacology, and dosage details, for ...
    5-15-2013
  • In Vivo Imaging Agent
    molecular tomography imaging, can provide a noninvasive approach to generate consistent GFR measurements in animal models of kidney disease, dysfunction, and drug toxicity. ...
    5-15-2013
  • Highlights from AACR
    ... rate in vivo to assess animal models of kidney disease, dysfunction, and drug toxicity. ... of a drug candidate and its potential for kidney toxicity in the same animal study. ...
    5-15-2013
  • Diversifying Your Antibody Portfolio
    difficulty in triggering an immune response in both wild-type and knock-out animals and often confers toxicity together with animal suffering without achieving the desired outcome. ...
    5-15-2013
  • Emergent, Caisson Collaborating to Optimize Heparosan Drug Delivery...
    patient experience, as it is intended to be a safer alternative to polyethylene glycol, a polymer-based drug delivery system associated with toxicity, among other unwanted effects. ...
    5-1-2013
  • Metabolomics Advances Reshape Dx Arena
    ... Beecher. "What toxicities should we expect? What is the biological reason for this toxicity?" NextGen plans to set up internal biomarker and toxicology discovery departments based ...
    5-1-2013
  • Human iPSC-Derived Hepatocytes
    Functional Model Tissue for In Vitro Predictive Metabolism, Toxicity, and Disease Modeling ... Data shown are courtesy of Promega. In addition, predictive toxicity models could also ...
    5-1-2013
  • Mitochondrial Toxicity Assays
    A new series of assays called the MitoVir platform evaluate mitochondrial toxicity by examining inhibition of the ribonucleoside triphosphates that are substrates for the human ...
    5-1-2013
  • Kidney Toxicity Panels
    The toxicity panels contain six of the seven markers approved by the FDA and EMEA for use in preclinical kidney toxicity assessment. Included in these panels are several other ...
    5-1-2013
  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    ... The effects of FAP-activated prodrugs on tumor growth and host toxicity were also tested ... with minimal systemic toxicity, whereas non-FAP cleavable prodrugs proved inactive. ...
    5-1-2013
  • Goodwin, Coldstream Team Up to Tackle ADCs
    The result will be improved therapeutic effectiveness with minimal toxicity when compared to traditional therapeutic approaches," predicted Muctarr Sesay, Ph.D., GBI's vp of ...
    4-25-2013
  • Performing "Informative Clinical Trials" in Mice
    ... In addition to the severe immunodeficiency (no functional B, T, or NK cells) and long life span, the NSG mice are resistant to estradiol toxicity, therefore supporting the ...
    4-17-2013
  • Advertorial: ACEA Biosciences
    cancer, regenerative medicine, inflammation, microbial infection, and toxicity research. ... of morphological dynamics, strength of adhesion, viability, proliferation, and toxicity. ...
    4-15-2013
  • Transfection Reagent
    in breast cancer cell types including MCF-7, MDA-MB-231, MDA-MB-453, MDA-MB-468, and T47D. It can also help maintain cell density and reduce experimental biases due to toxicity.
    4-15-2013
  • Aeterna Zentaris Sharing Costs, Profits for Cancer Drug
    While the overall survival after single agent AEZS-108 was similar to that reported for modern triple-combination chemotherapy, it was achieved with lower toxicity, according to ...
    4-10-2013
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    Journal Articles

  • Toxic Effects on and Structure-Toxicity Relationships of Phenylpropano...
    Sandra R.L. Santos, Viviane B. Silva, Manuela A. Melo, Juliana D.F. Barbosa, Roseli L.C. Santos, Damião P. de Sousa, Sócrates C.H. Cavalcanti
    Vector-Borne and Zoonotic Diseases
    Toxic Effects on and Structure-Toxicity Relationships of Phenylpropanoids, Terpenes, and ... To aid future work on the search for larvicidal compounds, the structure-toxicity ...
  • Quantitative Assessment of Islets of Langerhans Encapsulated...
    Amy S. Johnson, Esther O'Sullivan, Laura N. D'Aoust, Abdulkadir Omer, Susan Bonner-Weir, Robert J. Fisher, Gordon C. Weir, Clark K. Colton
    Tissue Engineering, Part C: Methods
    Biocompatibility tests revealed toxicity at the islet periphery associated with the lipid ... hypoxic conditions, but reformulation of the PFC emulsion is needed to reduce toxicity.
  • Bioprinted Nanoparticles for Tissue Engineering Applications
    Kivilcim Buyukhatipoglu, Robert Chang, Wei Sun, Alisa Morss Clyne
    Tissue Engineering, Part C: Methods
    No changes were observed in any samples after 36?h, suggesting that cell viability stabilized following the initial nanoparticle toxicity effect. Nanoparticles in the alginate and ...
  • Comparison of Viral and Nonviral Vectors for Gene Transfer to...
    Brian Kealy, Aaron Liew, Jill M. McMahon, Thomas Ritter, Aideen O'Doherty, Melissa Hoare, Udo Greiser, Erin E. Vaughan, Martin Maenz, Ciara O'Shea, Frank Barry, Timothy O'Brien
    Tissue Engineering, Part C: Methods
    and nonviral plasmid/liposome DNA vectors to deliver the green fluorescence protein reporter gene to human early EPCs to determine efficacy and vector-related cell toxicity. ...

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