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Search Results - Small Molecules
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  • Improving Proteomics Approaches
    ... As part of its mandate, SGC has begun investigating chemical probes, mostly small molecules, that bind to protein targets. "These are not necessarily drug candidates, as the leap ...
    5-15-2013
  • Mass Spec Provides Peek into PTMs
    ... profile proteins, lipids, drug, and small molecule metabolites in tissues, but it ... Proteins are highly dynamic molecules that are in many ways more difficult to analyze than ...
    5-15-2013
  • Softening the Blow from FOLFOX Treatment
    ... by overproduction of harmful oxygen/nitrogen molecules, such as during chemotherapy. ... The company's pipeline includes a PLED-derivative (PP-099) being evaluated in a small ...
    5-15-2013
  • Highlights from AACR
    ... the instrument can measure protein-protein or protein-small molecule interactions. ... digital pathology analysis software for detecting and quantifying RNA molecules in a cell. ...
    5-15-2013
  • Lilly Halts Development of Lymphoma Drug After Phase III Failure
    ... Gaynor said in the statement. Those two Phase III molecules are necitumumab, indicated for squamous non-small cell lung cancer; and ramucirumab for breast cancer, colorectal ...
    5-10-2013
  • Nimbus, Shire Collaborate to Co-Develop Small Molecule Treatments
    Nimbus Discovery has entered a co-development agreement with Shire focused on small ... Under the terms of the agreement, Nimbus will profile molecules and deliver a drug ...
    5-8-2013
  • Harnessing the Power of Kinase Inhibitors
    ... Hoflack. "Oncodesign offers a new technology, where we obtain high selectivity and potency but still use small molecules." Dr. Hoflack indicated that Oncodesign's diverse ...
    5-8-2013
  • A Boy And His Atom: The World's Smallest Movie
    to move thousands of carbon monoxide molecules (two atoms stacked on top of each other), all in pursuit of making a movie so small it can be seen only when you magnify it 100 ...
    5-2-2013
  • WATCH: A Boy and His Atom
    In that spirit, IBM researchers used a scanning tunneling microscope to move thousands of carbon monoxide molecules, all in pursuit of making a movie so small it can be seen only ...
    5-2-2013
  • Critical Tools for Oligo Characterization
    Now that oligo drugs are nearing late development and commercialization, analytical tools for speeding process development will come to the fore as they have with small molecules ...
    5-1-2013
  • Exposing the Exposome
    ... Rappaport. In analyzing small molecules from the blood, one of the challenges is the inability to predict the ones that are meaningful indicators of exposure. "I have proposed the ...
    5-1-2013
  • Biomarkers Take Center Stage
    ... binds to proteins and other molecules in solution, much like the antigen-binding site of antibodies. Unlike antibodies, Affimers are relatively small (13 KDa), ...
    5-1-2013
  • Metabolomics Advances Reshape Dx Arena
    ... ion mobility separations technology to provide greater analytical selectivity, specificity, and structural elucidation for applications ranging from proteins to small molecules. ...
    5-1-2013
  • Separation of Therapeutic Biomolecules
    ... There is no surface binding, and the active core retains only molecules smaller than the ... the pressure/flow properties of a large bead with the resolution of a small bead. Dr. ...
    5-1-2013
  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    for "druggable" molecules unique to tumor stromal cells and the tumor microenvironment. ... Dr. Puré's laboratory focuses on the use of small molecule inhibitors to inhibit FAP ...
    5-1-2013
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    Journal Articles

  • Efficient Generation of Nonhuman Primate Induced Pluripotent...
    Bonan Zhong, Grant D. Trobridge, Xiaobing Zhang, Korashon L. Watts, Aravind Ramakrishnan, Martin Wohlfahrt, Jennifer E. Adair, Hans-Peter Kiem
    Stem Cells and Development
    Using these vectors in combination with small molecules, we were able to efficiently and reproducibly generate nonhuman primate iPS cells from pigtailed macaques (Macaca ...
  • Purmorphamine Increases DARPP-32 Differentiation in Human Striatal...
    Gehan El-Akabawy, Lourdes Martinez Medina, Aaron Jeffries, Jack Price, Michel Modo
    Stem Cells and Development
    pathway to increase neuronal differentiation. These results demonstrate that small synthetic molecules can play a pivotal role in directing the differentiation of NSCs to optimize ...
  • Expansion of the Human Adipose-Derived Stromal Vascular Cell...
    Joydeep Basu, Christopher W. Genheimer, Kelly I. Guthrie, Namrata Sangha, Sarah F. Quinlan, Andrew T. Bruce, Bethany Reavis, Craig Halberstadt, Roger M. Ilagan, John W. Ludlow
    Tissue Engineering, Part C: Methods
    and functional responses to small molecules modulating SMC-related developmental pathways and compared the results to those obtained with functionally validated MSC cultures. ...
  • Metabolomic Analysis of Resveratrol-Induced Effects in the Human...
    Walter Jäger, Alexandra Gruber, Benedikt Giessrigl, Georg Krupitza, Thomas Szekeres, Denise Sonntag
    OMICS: A Journal of Integrative Biology
    subsequent metabolism by 12-lipoxygenase. In conclusion, metabolomic analysis elucidated several small molecules as markers for the response of breast cancer cells to resveratrol.

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