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Search Results - Sirtuin
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  • "Conclusive Evidence" for Red Wine's Health and Longevity Benefits
    in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin, SIRT1, that protects the body from diseases by revving up the mitochondria. ...
    3-8-2013
  • "Molecular Fountain of Youth" May Exist
    Can we actually reverse aging? This is something we're hoping to understand and accomplish." The importance of the sirtuin family of proteins to the aging process is becoming ...
    2-1-2013
  • Detection of Lysine Deacetylase Activities
    developer or luciferase enzymes prior to the specific HDAC or sirtuin deacetylation event. ... activity assays: Recombinant HDAC or sirtuin was diluted to 400 or 800 ng/mL, ...
    11-1-2011
  • miRNA Drugs Close In on Clinical Debut
    ... of metabolic homeostasis such as fatty acid beta-oxidation enzymes, the fasting/stress-response regulator AMP kinase, and the sirtuin and glucose/lipid regulator SIRT6." Dr. ...
    3-15-2011
  • 2010 in Review: Biotechnology Highlights
    ... investment made two years ago: Its lead sirtuin activator, which was obtained through the ... This candidate was the industry's most advanced sirtuin-based drug. GSK and others ...
    12-30-2010
  • Parkinson Disease Research in Doldrums
    ... Even sirtuins are getting into the act, as investigators reported discovery of a potent sirtuin 2 (SIRT2) inhibitor that rescued alpha-synuclein toxicity and modified inclusion ...
    9-15-2010
  • No New Parkinson Disease Drug Expected Anytime Soon
    ... Even sirtuins are getting into the act, as investigators reported discovery of a potent sirtuin 2 (SIRT2) inhibitor that rescued alpha-synuclein toxicity and modified inclusion ...
    8-16-2010
  • Examining Both Sides of the Sirtuin Coin
    Given the sirtuin family of enzymes' broad range of fundamental biological effects across ... Phase I testing of Elixir's SIRT1 (sirtuin-1) inhibitor, a potentially ...
    2-22-2010
  • Sirtuins: Antiaging Medicines or Marketing?
    ... Based on its research, Sirtris is forging ahead with its Sirtuin program with NCEs that ... Since then neither GSK nor Sirtris has put out a press release related to its Sirtuin ...
    2-16-2010
  • Search Intensifies for Diabetes Drugs
    is the most well-studied of the seven sirtuin family members. (David Shopper ... One challenge is trying to understand which sirtuin to target for a specific disease. ...
    11-1-2009
  • Methodology Garners Researchers' Interest
    HTRF Technology Finds Applications in GPCR, Kinase, and Sirtuin Detection Figure 1. Gq signaling pathway Homogenous time-resolved fluorescence (HTRF) entered the drug-screening ...
    11-15-2008
  • MethylGene to Stop Backing Clinical Program in Collaboration...
    under the original transaction to codevelop and copromote subsequent compounds, including second-generation histone deacetylase inhibitors (HDAC) and sirtuin inhibitors for cancer. ...
    9-19-2008
  • Elixir Signs License Agreement with Boston University for Use...
    Elixir Pharmaceuticals gained an exclusive license to Boston University's intellectual property covering the use of modulators of SIRT1, a member of the sirtuin class of protein ...
    7-1-2008
  • GSK to Snag Sirtris for About $716.93M
    Sirtris focuses on sirtuins, a recently discovered class of enzymes that are believed to be involved in the aging process. The firm has been exploiting sirtuin modulation through ...
    4-23-2008
  • Addressing Unmet Type 2 Diabetes Needs
    ... In addition, at least one type of early-stage program listed in Table 2 , development of sirtuin modulators, has the potential for resulting in agents that may slow or reverse ...
    1-1-2008
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    Journal Articles

  • Superoxide mediates acute liver injury in irradiated mice lacking...
    Mitchell C. Coleman, Alicia K. Olivier, James A. Jacobus, Kranti Ashok Mapuskar, Gaowei Mao, Sean M Martin, Dennis P. Riley, David Gius, Douglas Robert Spitz
    Antioxidants & Redox Signaling
    Superoxide mediates acute liver injury in irradiated mice lacking Sirtuin 3 Antioxidants & Redox Signaling
  • Redox Regulation of Sirtuin-1 by S -Glutathiolation
    Rebecca S. Zee, Chris B. Yoo, David R. Pimentel, David H. Perlman, Joseph R. Burgoyne, Xiuyun Hou, Mark E. McComb, Catherine E. Costello, Richard A. Cohen, Markus M. Bachschmid
    Antioxidants & Redox Signaling
    Redox Regulation of Sirtuin-1 by S -Glutathiolation Antioxidants & Redox Signaling
  • Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction
    Alejandro Martin-Montalvo, Rafael de Cabo
    Antioxidants & Redox Signaling
    We discuss the master regulators of energy metabolism such as AMP-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1) among others that have been demonstrated to activate ...
  • Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and...
    Zhen Chen, Tzu-Pin Shentu, Liang Wen, David A. Johnson, John Y.-J. Shyy
    Antioxidants & Redox Signaling
    Oxidative stress is a common denominator of various risk factors contributing to endothelial dysfunction and vascular diseases. Accumulated evidence suggests that sirtuin 1 (SIRT1) ...

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