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Search Results - Rat Models
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  • Molecular Imaging Driving Development
    ... pharmacodynamics and pharmacokinetics in preclinical models. Speaking with GEN, Dr. ... a calcium sensor and co-expressed it with a light-sensitive photoreceptor in rat neurons. ...
    8-1-2013
  • Closer-to-Real 3D Cell Culture Advances
    ... hepatotoxicity prediction among different models including the HepG2 (glu/gal) cultured hepatocyte model, primary hepatocytes (rat/Human) HepaRG (tumor derived human hepatocyte) ...
    7-3-2013
  • Live Content Imaging
    The range of exemplified kinetic phenotypic assays includes mono- and co-culture models of ... Figure 2C shows kinetic measurements of neurite outgrowth in 96-well plates from rat ...
    6-1-2013
  • Comparative Genomics: Insights into Disease Susceptibility
    ... manatee, the chinchilla, the naked mole rat, the star-nosed mole, and the white ... mammalian genomes helps in developing models of human disease based on genetic studies ...
    5-1-2013
  • Advances in RNAi Tools and Technologies
    designs to target all human, mouse, and rat genes in highly potent and specific fashion. ... to be highly stable when injected into the bloodstream of animal models, he continues. ...
    4-15-2013
  • Predicting Drug Toxicity in Humans
    ... Biopharmaceutical companies are looking to avoid false positives with their drugs. For instance, troglitazone may be safe in rat models, but 1 in 2,000 humans suffers from fatal ...
    4-1-2013
  • Genome Editing for R&D and Therapeutics
    ... We provide off-the-shelf specific ZFNs to target genes for human, mouse, and rat studies ... has been used to correct a variety of congenital liver diseases in animal models. ...
    3-1-2013
  • Footprint-Free, Site-Specific Gene Editing
    For example, they can be used to create models of disease by changing a wild-type locus to ... Figure 1. Homologous recombination (HR) in rat spermatogonial stem cells (SSCs) only ...
    3-1-2013
  • Taconic to Market Yecuris' Humanized Animal Models
    throughout India through a distribution agreement made earlier this month with Vivo Bio Tech, who gained rights to breed and distribute select Taconic mouse and rat models there. ...
    2-25-2013
  • Crunching Complex Data
    Translating insights gleaned from rodent models into greater knowledge of how humans ... told GEN. "We are talking about rat bronchial epithelial cells versus human ...
    2-15-2013
  • Better, Earlier ADME/Tox Predictions in Cells
    However, we can validate models that answer specific questions. As the use of in vitro ... and Mrp3 (red, baso-lateral) in B-CLEAR® rat hepatocytes. [Qualyst Transport Solutions] ...
    12-1-2012
  • 9 Ways to Optimize Preclinical Imaging
    Absolute T2-weighted and diffusion MRI from rat brain 24 and 48 hours post-tMCAO ... post-uptake, bottom row). Preclinical models and the modalities used within them are ...
    10-22-2012
  • Prizes and Quackery Dominate iPS Cell News
    ... We are putting them into rat and mouse models of disease then we will be in the clinic in 2014 for both programs and hope to enter Phase I later that year. "Our recent insights ...
    10-19-2012
  • Sigma Divisions Establish Screening Technology Deals
    Sigma Life Science's Sigma Advanced Genetic Engineering (SAGE) Labs, and Ekam Imaging are teaming up to develop a suite of preclinical services that will combine SAGE's rat models ...
    10-16-2012
  • Tissue Engineering No Easy Cell
    ... Grikscheit leads a research team focused on growing rat, mouse, and pig intestinal tissue ... giants interested in successful in vitro models for tissue engineering, but hesitant to ...
    10-9-2012
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    Journal Articles

  • Cortical Reorganisation after Experimental Traumatic Brain Injury...
    Neil G Harris, Szu-Fu Chen, John Pickard
    Journal of Neurotrauma
    Recent evidence in the rat controlled cortical impact (CCI) injury model shows that the ... to the differences and similarities that exist between rodent models of stroke and TBI.
  • Protective Effects of Ginger Root Extract on Alzheimer Disease...
    Gao-feng Zeng, Zhi-yong Zhang, Li Lu, De-qiang Xiao, Shao-hui Zong, Jian-ming He
    Rejuvenation Research
    Abstract: To assess the ability of a traditional Chinese medicinal ginger root extract (GRE) to prevent behavioural dysfunction in the Alzheimer's disease rat model. Rat AD models ...
  • Neonatal Desensitization Supports Long-Term Survival and Functional...
    Shufang Zhang, Yang Zi Jiang, Wei Zhang, Longkun Chen, Tong Tong, Wanlu Liu, Qin Mu, Hua Liu, Junfeng Ji, Hong Wei Ouyang, Xiaohui Zou
    Stem Cells and Development
    Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression ... a powerful tool for preclinical study of human cell-based therapies in animal models.
  • Blast-Induced Biomechanical Loading of the Rat: An Experimental...
    Aravind Sundaramurthy, Aaron Alai, Shailesh Ganpule, Aaron Holmberg, Erwan Plougonven, Namas Chandra
    Journal of Neurotrauma
    Blast-Induced Biomechanical Loading of the Rat: An Experimental and Anatomically Accurate ... In vivo animal models in conjunction with shock tubes are extensively used in laboratories ...

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