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Search Results - Rat Models
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  • Comparative Genomics: Insights into Disease Susceptibility
    ... manatee, the chinchilla, the naked mole rat, the star-nosed mole, and the white ... mammalian genomes helps in developing models of human disease based on genetic studies ...
    5-1-2013
  • Advances in RNAi Tools and Technologies
    designs to target all human, mouse, and rat genes in highly potent and specific fashion. ... to be highly stable when injected into the bloodstream of animal models, he continues. ...
    4-15-2013
  • Predicting Drug Toxicity in Humans
    ... Biopharmaceutical companies are looking to avoid false positives with their drugs. For instance, troglitazone may be safe in rat models, but 1 in 2,000 humans suffers from fatal ...
    4-1-2013
  • Genome Editing for R&D and Therapeutics
    ... We provide off-the-shelf specific ZFNs to target genes for human, mouse, and rat studies ... has been used to correct a variety of congenital liver diseases in animal models. ...
    3-1-2013
  • Footprint-Free, Site-Specific Gene Editing
    For example, they can be used to create models of disease by changing a wild-type locus to ... Figure 1. Homologous recombination (HR) in rat spermatogonial stem cells (SSCs) only ...
    3-1-2013
  • Taconic to Market Yecuris' Humanized Animal Models
    throughout India through a distribution agreement made earlier this month with Vivo Bio Tech, who gained rights to breed and distribute select Taconic mouse and rat models there. ...
    2-25-2013
  • Crunching Complex Data
    Translating insights gleaned from rodent models into greater knowledge of how humans ... told GEN. "We are talking about rat bronchial epithelial cells versus human ...
    2-15-2013
  • Better, Earlier ADME/Tox Predictions in Cells
    However, we can validate models that answer specific questions. As the use of in vitro ... and Mrp3 (red, baso-lateral) in B-CLEAR® rat hepatocytes. [Qualyst Transport Solutions] ...
    12-1-2012
  • 9 Ways to Optimize Preclinical Imaging
    Absolute T2-weighted and diffusion MRI from rat brain 24 and 48 hours post-tMCAO ... post-uptake, bottom row). Preclinical models and the modalities used within them are ...
    10-22-2012
  • Prizes and Quackery Dominate iPS Cell News
    ... We are putting them into rat and mouse models of disease then we will be in the clinic in 2014 for both programs and hope to enter Phase I later that year. "Our recent insights ...
    10-19-2012
  • Sigma Divisions Establish Screening Technology Deals
    Sigma Life Science's Sigma Advanced Genetic Engineering (SAGE) Labs, and Ekam Imaging are teaming up to develop a suite of preclinical services that will combine SAGE's rat models ...
    10-16-2012
  • Tissue Engineering No Easy Cell
    ... Grikscheit leads a research team focused on growing rat, mouse, and pig intestinal tissue ... giants interested in successful in vitro models for tissue engineering, but hesitant to ...
    10-9-2012
  • Monday's News in a Nutshell
    ... in preclinical models, which demonstrated similar functionality to normal human platelets. ... by Trellis and its partners, using OMT's OmniRat(tm) transgenic rat antibody platform. ...
    10-9-2012
  • Animal Models Get Closer to Mimicking Humans
    ... Gamber. "Moreover, the anatomy, physiology, and social behavior of rat is closer to human than the mouse is, and we are seeing phenotypes modeling human disease in rat models that ...
    10-1-2012
  • Advertorial: Indigo Biosciences
    ... The availability of common orthologs such as rat and mouse allows chemical and pharmaceutical companies to validate animal models, and nutritional companies can check for activity ...
    10-1-2012
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    Journal Articles

  • Neuromuscular Junction Formation Between Human Stem-Cell-Derived...
    Xiufang Guo, Mainak Das, John Rumsey, Mercedes Gonzalez, Maria Stancescu, James Hickman
    Tissue Engineering, Part C: Methods
    No in vitro studies have demonstrated human MN to rat muscle synapse formation, although numerous studies have attempted to implant human stem cells into rat models to determine if ...
  • Metabolic Control Through Hepatocyte and Adipose Tissue Cross...
    Maria Angela Guzzardi, Claudio Domenici, Arti Ahluwalia
    Tissue Engineering, Part A
    pathways; however, traditional in vitro models cannot mimic these interactions because ... Primary rat hepatocytes and adipose tissue were cultured separately and together in ...
  • Suitability of Animal Models for Studying Radiation-Induced Thyroid...
    Manoj Gandhi, Yuri E. Nikiforov
    Thyroid
    Suitability of Animal Models for Studying Radiation-Induced Thyroid Cancer in Humans: Evidence from Nuclear Architecture Thyroid Background: Rat and mouse have been widely used to ...
  • Application of an Endothelialized Modular Construct for Islet...
    Rohini Gupta, Michael V. Sefton
    Tissue Engineering, Part A
    Application of an Endothelialized Modular Construct for Islet Transplantation in Syngeneic and Allogeneic Immunosuppressed Rat Models Tissue Engineering, Part A Modular tissue ...

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