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  • AstraZeneca Drops RA Compound After Phase III Disappointments
    AstraZeneca has decided not to proceed with regulatory filings for its rheumatoid arthritis candidate fostamatinib. AstraZeneca Drops RA Compound After Phase III Disappointments
    6-4-2013
  • GSK Grabs MorphoSys RA Candidate in Deal Worth Up to $548M
    which has concluded Phase I/II development for mild to moderate rheumatoid arthritis (RA). ... moderate rheumatoid arthritis. GSK Grabs MorphoSys RA Candidate in Deal Worth Up to $548M
    6-3-2013
  • AbbVie Expands Galapagos Collaboration to Include Crohn's Disease
    of GLPG0634 beyond rheumatoid arthritis (RA), for which the companies are about to ... will start early next year, and take place at the same time as the Phase IIb RA trial. ...
    5-17-2013
  • Bayer Prostate Cancer Drug Gains FDA Approval
    Bayer HealthCare said yesterday it is weeks away from joining Algeta in bringing to the U.S. market their advanced prostate cancer drug Xofigo® (radium Ra 223 dichloride) ...
    5-16-2013
  • Study: Protein Secreted by Certain Fat Cells Can Trigger RA
    messenger RNA for the RA-associated protein profactor D (pro-FD) in its mouse model study. ... Based on his team's discovery of pro-factor D in mice with RA, Banda and his colleagues ...
    5-8-2013
  • Biomarkers Take Center Stage
    ... including rheumatoid arthritis (RA), Crohn's disease, and psoriasis, among others. ... drugs)-naïve RA (rheumatoid arthritis) vs. knee OA (osteoarthritis) patient cohorts. ...
    5-1-2013
  • Biosimilars: 10 Drugs to Watch
    ... U.S. study recruiting participants as of April 17, according to ClinicalTrials.gov (NCT01682512) Celltrion and Hospira: Conducting Phase I trial in South Korea of CT-P10 for RA and ...
    4-22-2013
  • Biosimilars: Not So Far So Fast
    ... NHL, Merck with MK8808 in RA patients, as well as South Korean Celltrion in a joint venture with Hospira, testing CT-P10 in a Phase I trial for RA and another Phase I for lymphoma. ...
    3-15-2013
  • Receptos Licenses AbbVie Antibody for Co-Development
    ... The AbbVie immunology pipeline also includes two Phase II drug candidates-BT-061 for rheumatoid arthritis (RA) and psoriasis, and GLPG0634, also for RA. AbbVie completed a ...
    3-13-2013
  • Merck Doubles Lycera Bet to $600M+
    psoriasis, and rheumatoid arthritis (RA). "There are substantial unmet medical ... holds only North American rights, and the RA drug, MK-8457. Merck's need to boost its ...
    2-12-2013
  • Top 10 VC & Biopharma Equity Deals of 2012
    Series D financing Participating firms: ARCH Venture Partners, Forbion Capital Partners, RA Capital Management, Third Rock Ventures, TVM Capital, and two undisclosed investors 4 ...
    2-8-2013
  • Lilly Ends Phase III Rheumatoid Arthritis Program
    tabalumab for rheumatoid arthritis (RA), ending three Phase III trials of the drug ... the first quarter of 2013 toward ending the RA program for tabalumab, one of the company's ...
    2-7-2013
  • Janssen Pharmaceutica Pays Galapagos $5.3M
    novel small molecule therapeutics for the treatment of rheumatoid arthritis (RA), under which Janssen may select up to 12 programs from Galapagos' internally identified RA targets. ...
    1-16-2013
  • Galapagos Deals Aim to Shore Up Drug Discovery
    ... of JAK1, for rheumatoid arthritis (RA) and potentially other inflammatory diseases. ... successful completion of the RA Phase II studies that meet undisclosed preagreed criteria. ...
    1-15-2013
  • Top 20 Venture Capital Firms
    ... Principia, Promedior Pharmaceuticals, Ra Pharmaceuticals, Replidyne, Ribozyme ... Therapeutics, Psyadon Pharmaceuticals, Ra Pharma, Rhythm, Roka Bioscience, Satori ...
    12-17-2012
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    Journal Articles

  • Impaired Cardiovascular Function Caused by Different Stressors...
    Jing Chen
    Zebrafish
    (TCDD) or retinoic acid (RA) produces very similar signs of heart ... To test this hypothesis, we compared the effects of TCDD, RA, carbaryl, valproic acid ...
  • Chemical Composition and Antioxidant, Anti-Inflammatory, and...
    Jalila Bekir, Mohamed Mars, Patricia Vicendo, Amira Fterrich, Jalloul Bouajila
    Journal of Medicinal Food
    For antiinflammatory activity, all varieties were active, ZH variety was the strongest (2.5±0.1 mg/L). CH, ES and RA pomegranate varieties were no active against human breast ...
  • Defective Efficacy of Retinoic Acid Treatment in Patients with...
    F. Courbon, S. Zerdoud, D. Bastie, Fr. Archambaud, M. Hoff, N. Eche, I. Berry, Ph. Caron
    Thyroid
    This study aims to assess the capability of the retinoic acid (RA) treatment to reinforce ... The redifferentiating effect of RA was evaluated by serum thyroglobulin (Tg) monitoring ...
  • Cigarette Smoke Condensate Extracts Induce IL-1-Beta Production...
    Miki Adachi, Shosuke Okamoto, Satomi Chujyo, Tomohiro Arakawa, Megumi Yokoyama, Kyohei Yamada, Aki Hayashi, Kunihiko Akita, Masafumi Takeno, Saotomo Itoh, Takemasa Takii, Yuko Waguri-Nagaya, Takanobu Otsuka, Kazuichi Hayakawa, Keiji Miyazawa, Kikuo Onozaki
    Journal of Interferon & Cytokine Research
    risk factor for rheumatoid arthritis (RA), and synoviocyte-derived proinflammatory cytokines are implicated in the pathogenesis of RA. We have reported that aryl hydrocarbon or ...

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