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Search Results - Protein-Protein Interactions
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  • Fluorescence Lifetime Assays
    ... Figure 1B. Inhibition of BRD4(1) binding to histone H4 acetylated peptide by the small molecule inhibitor JQ1(+). In drug discovery, the disruption of protein-protein interactions ...
    5-15-2013
  • Highlights from AACR
    ... label-free kinetic measurements for molecular interaction analysis with high sensitivity, the instrument can measure protein-protein or protein-small molecule interactions. ...
    5-15-2013
  • Targeting Protein-Protein Interactions
    Researchers are scheduled to present the cutting edge of their tools and technologies targeting protein-protein interactions (PPIs) at Select Biosciences' upcoming "Discovery ...
    2-15-2013
  • SPR Instrument
    This class of SPR instrumentation has been designed to measure protein/protein and protein-small molecule interactions (down to 100 Da) in a high-throughput 96/384-well platform ...
    2-15-2013
  • Sigma and Olink Partner on Protein-Protein Interaction Assay
    to distribute worldwide Olink Bioscience's Duolink® In Situ products, which present a new method for imaging and measuring protein-protein interactions in unmodified cells. ...
    2-12-2013
  • Epigenetics: Promising Field Delivers
    By surveying in vivo protein-protein interactions on nascent DNA sequences at replication forks and examining their posttranslational modifications, Dr. Mazo and colleagues showed ...
    1-15-2013
  • Lab Automation Sparks Creativity
    ... high-resolution multichannel imaging devices integrated with powerful image analysis algorithms/modules made many complex analyses, such as protein-protein interactions, possible." ...
    1-1-2013
  • Close-Up View of Life Science Microscopy
    ... Live-cell/organism imaging requires faster image acquisition to capture biological and physiological processes as they are happening, such as protein-protein interactions, cell ...
    12-1-2012
  • Visualizing Cell Signaling Pathways
    ... Challenges Remain Despite recent methodological advances, the study of protein-protein interactions still presents multiple types of experimental challenges, particularly when ...
    11-1-2012
  • Peering into Subcellular Domains
    This provides a remarkable visualization of dynamic protein function to monitor protein-protein interactions (e.g., how signaling complexes assemble) where the distance of ...
    11-1-2012
  • Complix Awarded $2.5M to Develop Alphabodies
    with efficient cell penetration and stability. "Although intracellular protein-protein interactions are known to be involved in a variety of important disease processes, such ...
    10-30-2012
  • Optimizing Protein Expression
    ... input into an equation that calculates for each solution condition the second virial coefficient, a thermodynamic term that represents the sum of all protein-protein interactions. ...
    9-15-2012
  • Devising a Protein Formulation Strategy
    formulation conditions (e.g., temperature, concentration, pH, buffer), protein-protein interactions, and variations of a molecule. "A major challenge in formulation development ...
    9-15-2012
  • Acquisitions Grow Corning's Product Line
    ... Types of Epic assays include small-molecule binding, functional protease, kinase, protein-protein interactions, G-protein coupled receptors, viral detection, and ion channels. ...
    9-15-2012
  • Silicon Peptide Chips Could Transform Diagnostics
    However, they say the scalable platform could be applied to a broad range of proteomics studies, including epitope mapping and characterizing protein-protein interactions, as well ...
    8-21-2012
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    Journal Articles

  • Genome-Scale Gene Function Prediction Using Multiple Sources...
    Trupti Joshi, Yu Chen, Jeffrey M. Becker, Nickolai Alexandrov, Dong Xu
    OMICS: A Journal of Integrative Biology
    information from protein-protein interactions, protein complexes, microarray gene expression profiles, and annotations of known proteins through an integrative statistical model. ...
  • Polyclonal Antibodies Against Human Proteasome Subunits PSMA3...
    Veronika A. Livinskaya, Vadim A. Ivanov, Olga A. Fedorova, Daria N. Vorontsova, Nick A. Barlev, Andrey A. Nikiforov
    Hybridoma
    and/or overexpressed proteasome subunits, which facilitates subsequent analysis of their post-translational modifications as well as protein-protein interactions in vivo.
  • Differential Effects of TNF-α and IFN-γ on Gene Transcription...
    Raymond W. Ganster, Zhong Guo, Lifang Shao, David A. Geller
    Journal of Interferon & Cytokine Research
    involves complex interactions between NF-?B and Stat families of transcription factors. ... Coimmunoprecipitation provides evidence for a direct NF-?B/Stat1 protein-protein ...
  • Modulating Target Site Selection During Human Immunodeficiency...
    Angela Ciuffi, Tracy L. Diamond, Young Hwang, Heather M. Marshall, Frederic D. Bushman
    Human Gene Therapy and Part B: Methods
    via a tethering mechanism, and provide proof of concept for the idea that protein-protein interactions might be engineered to constrain integration site selection during human ...

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