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Search Results - Protein Folding
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  • Removing the Receptor Deconvolution Bottleneck
    10% using techniques such as standard protein chips or immunoprecipitation and mass ... This allows for normal trafficking of the proteins to the cell surface, correct folding in ...
    8-1-2013
  • Nudging Difficult-to-Express Proteins Along
    proper targeting, insertion, folding, and efficient accumulation of integral membrane proteins in the E. coli membrane," Dr. Kim said. The protein candidates for expression ...
    6-15-2013
  • Drug Target Research Center Planned for UMass Amherst
    Nearly 50 researchers will be associated with Models to Medicine. One of them, Lila Gierasch, runs a lab focused on how protein homeostasis networks facilitate proper folding in ...
    6-7-2013
  • Separation of Therapeutic Biomolecules
    ... Dr. Hearn stated that water is fundamental in protein folding, mainly due to its role in defining hydrogen bonding and hydrophobic interactions: "water is indispensable for ...
    5-1-2013
  • Boosting Downstream Productivity
    Downstream processing steps can represent up to 60% of the production costs for a protein, ... such as charge variants, glycosylation-, folding-, and truncated mAb-variants. "As ...
    4-15-2013
  • Scientists Print 3D Materials Resembling Biological Tissues
    The researchers demonstrate that the printed material can make folding movements similar ... The droplets can be printed with protein pores to form pathways through the network that ...
    4-4-2013
  • The Genesis of a Discovery: First Steps
    In the 1940s it was still being debated as whether it was the nuclear protein, the DNA or ... great flexibility to allow folding of the structure to fit into the cell nucleus. ...
    4-1-2013
  • DNA to Hang Your Hat On
    single strands of DNA to direct the folding of a long, single strand of DNA, viral ... biological experiments to model complex protein assemblies. 3D DNA Origami Scientists ...
    3-20-2013
  • Increasing Prep HPLC Column Lifetime
    Aggressive Wash Conditions HPLC is a widely used tool in peptide and protein purification. ... During folding of these compounds, polymerization and scrambling may occur, which can lead ...
    3-1-2013
  • Distributed Computing Meets Drug Discovery
    While it won't be the first distributed computing effort in life-sci-Folding@home, based ... is in bridging the chasm between a protein structure of a target, and having a drug ...
    2-28-2013
  • En Bloc Analysis of Epigenetic Publications
    rather chemical modifications of DNA, folding, and complex formation that render genes ... It is also clear that karyopherin, a protein involved in transnuclear transport, is a ...
    2-1-2013
  • Use of Recombinant Human Proteins
    Such authenticity includes structural aspects such as glycosylation, proteolytic processing for mature protein formation, disulfide bond formation, and folding into the proper ...
    1-15-2013
  • Tackling Transfection Tasks
    ... Kim. "We also introduced an endoproteolytic cleavage site to improve protein folding and cytotoxic T lymphocyte processing." In addition, Inovio has developed an ...
    1-1-2013
  • Twisting and Turning for Better Protein Expression
    ... In those situations DNA2.0's approach can improve secretion and folding. "That's a high-level definition of optimization: not just total protein, but total active protein. Our ...
    1-1-2013
  • Inventive Approaches Redefine Downstream Ops
    ... same time co-expressing helper elements, folding, and secretion of the Fab, which is now ... Of note are antibody-drug conjugates and modifications of the protein molecule to ...
    12-1-2012
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    Journal Articles

  • Glutathione peroxidase 7 utilizes hydrogen peroxide generated...
    Lei Wang, Lihui Zhang, Yingbo Niu, Roberto Sitia, Chih-Chen Wang
    Antioxidants & Redox Signaling
    Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding Antioxidants & Redox Signaling
  • Engineered Pathways for Correct Disulfide Bond Oxidation
    Guoping Ren, James C.A. Bardwell
    Antioxidants & Redox Signaling
    Antioxidants & Redox Signaling Abstract Correct formation of disulfide bonds is critical for protein folding. We find that cells lacking protein disulfide isomerases (PDIs) can use ...
  • Dynamics of Protein Damage in Yeast Frataxin Mutant Exposed to...
    Jin-Hee Kim, Miroslav Sedlak, Qiang Gao, Catherine P. Riley, Fred E. Regnier, Jiri Adamec
    OMICS: A Journal of Integrative Biology
    and cellular defense, transport, and folding (38.7%), suggesting a drop in energy ... and decrease in activity of enzymes involved in protein protection and regeneration. ...
  • The Diversity of Oxidative Protein Folding
    Adam M. Benham, Roberto Sitia
    Antioxidants & Redox Signaling
    The Diversity of Oxidative Protein Folding Antioxidants & Redox Signaling

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