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  • RuiYi Licenses mAb Development to China's Genor
    A commercial-scale cGMP production facility is in planning stages. RuiYi company is ... includes two monoclonal antibodies that target G protein-coupled receptors (GPCRs). ...
    5-16-2013
  • Heightened Characterization of Therapeutic mAbs Using a Novel...
    ... antibody developers Recombinant antibody QC/QA scientists Antibody production scientists Protein biochemists Protein/biological protein mass spectroscopists Carbohydrate ...
    5-15-2013
  • Highlights from AACR
    that its SmartFlare RNA detection probes detect native mRNA or miRNA in live cells in a nontoxic manner without affecting gene expression or production of a protein of interest. ...
    5-15-2013
  • Advertorial: Agilent Technologies
    as the most versatile analytical strategy for targeted protein analysis. From monitoring large-scale production processes to the discovery and validation of protein ...
    5-15-2013
  • Diversifying Your Antibody Portfolio
    ... FcRn transgenic rabbits are ideally suited for the development and production of anti-host cell protein lysate (HCP) polyclonal antibodies capable of recognizing weakly and highly ...
    5-15-2013
  • RuiYi, CMC Collaborate to Speed mAb Development
    is a CMO that specializes in custom services for scale up, as well as cGMP manufacture of protein-based therapeutics for preclinical, clinical trials, and in-market production. ...
    5-14-2013
  • Biogen Idec Pays Isis $3.5M for Antisense Drug Milestone
    ISIS-SMN Rx is an antisense drug designed to alter the splicing of a closely related gene (SMN2) to increase production of fully functional SMN protein. Isis received an up-front ...
    5-10-2013
  • Harnessing the Power of Kinase Inhibitors
    generic kinase substrate myelin basic protein), however not when using IKK-α protein ... target that would affect cytokine production by both innate and adaptive immunity, ...
    5-8-2013
  • New International Collaboration Aims to Develop Drugs, Diagnostics...
    development technologies; ChemDiv will provide access to its protein engineering, production, structural biology and structure-based drug discovery, medicinal ...
    5-2-2013
  • Migraines Linked to Gene Mutation
    In the laboratory, the team demonstrated that the mutation reduces the production of the ... Ptácek. "This is an enzyme, and so it modifies proteins. The question is, which protein ...
    5-2-2013
  • Novartis, Oxford BioMedica Ink Production Agreement for Lentiviral...
    Through this production agreement, Oxford BioMedica will be responsible for manufacturing ... In its announcement, Oxford BioMedica notes that CTL019 targets the protein CD19, which is ...
    5-1-2013
  • Two Proteins Found to Block Cancer Metastasis
    Importantly, increased Tsp-1 production was found specifically in the bone marrow myeloid ... activity of prosaposin was contained in only a 5-amino acid peptide region of the protein. ...
    5-1-2013
  • Separation of Therapeutic Biomolecules
    ... They were then refined and converted to a step elution protocol for larger scale production. Mixed-mode chromatography offers additional advantages for protein separation and ...
    5-1-2013
  • Twin Effort Hones In on Membrane Proteins
    ... The company's single-stage, "open system" production platform uses key protein-making cellular components, rather than cultured whole cells, explains Dr. Lenormand. In whole-cell ...
    5-1-2013
  • Testing for Residual Host Cell Protein & DNA
    What is the impact of host-cell impurities on clinical safety and efficacy? Dr. Kibbey: During the course of production of a therapeutic protein, host-cell DNA may remain in the ...
    5-1-2013
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    Journal Articles

  • Hepatic Differentiation of Human Embryonic Stem Cells Is Promoted...
    Toshio Miki, Alexander Ring, Jörg Gerlach
    Tissue Engineering, Part C: Methods
    Metabolism, hepatocyte-specific gene expression, protein expression, and hepatic function ... Ammonia metabolism activity and albumin production was observed in the 3D directed ...
  • Identification of the Chondrocyte Lineage Using Microfibril-Associated...
    Stephen Rapko, Mindy Zhang, Brenda Richards, Elizabeth Hutto, Sandra Dethlefsen, Stephen Duguay
    Tissue Engineering, Part C: Methods
    production comprised synovium. Chondrocyte and synovial cell cultures were then examined using a full transcriptome microarray analysis, which revealed cartilage link protein and ...
  • Scalable Platform for Human Embryonic Stem Cell Differentiation...
    Marti Lecina, Sherwin Ting, Andre Choo, Shaul Reuveny, Steve Oh
    Tissue Engineering, Part C: Methods
    cell (hESC)-derived cardiomyocyte (CM) production can provide a readily available source ... in serum-free media supplemented with SB203580 mitogen-activated protein kinase-inhibitor. ...
  • Hepatic Maturation of Human Fetal Hepatocytes in Four-Compartment...
    Alexander Ring, Jörg Gerlach, Grant Peters, Benjamin J. Pazin, Crescenzio F. Minervini, Morris E. Turner, Robert L. Thompson, Fabio Triolo, Bruno Gridelli, Toshio Miki
    Tissue Engineering, Part C: Methods
    Metabolism activity, hepatocyte-specific gene expression, protein expression, and hepatic function were investigated. Increased glucose consumption and lactate production indicated ...

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