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  • Hematologic Diagnostics Go with the Flow
    ... Rare event detection has mostly been used in acute lymphoblastic leukemias, but the ... For example, one subtype of HLH is caused by a deficiency in perforin, a protein that aids ...
    8-1-2013
  • Molecular Imaging Driving Development
    ... Quantifying treatment-related changes through texture analysis helps in the detection and ... The World's Brightest Luminescent Protein Luminescence (left) and fluorescence (right) ...
    8-1-2013
  • Removing the Receptor Deconvolution Bottleneck
    ... proteins, viruses), Retrogenix has developed and validated a range of detection systems for protein ligands (anti-His, anti-Flag, anti-V5, anti-Fc, biotin-streptavidin, ...
    8-1-2013
  • Big Need in IBD: Drugs to Slow Progression
    ... in a gene expression profile to enable detection of nonresponders with severe disease ... Patients taking EnteraGam(tm), a serum-derived bovine immunoglobulin/protein isolate for ...
    8-1-2013
  • High School Whiz Kids Win Scientific Prestige . . . and Big Bucks
    ... became interested in finding a better early-detection diagnostic test. The diagnostic method he developed detects the presence of pancreatic cancer's biomarker protein mesothelin. ...
    8-1-2013
  • Ultrasensitive Immunoassays for Translation of Biomarkers from...
    helps overcome challenges in the translation of protein biomarkers to the clinic. ... This detection system results in a count of discreet detection events above background ...
    7-31-2013
  • Analysis of N-Glycan Released from Biopharmaceutical Glycoproteins...
    Unlike conventional drugs, recombinant protein drugs are highly complex molecules with ... a chromaphore (2-aminobenzamide, 2-AB) in order to be analyzed by HPLC and UV detection. ...
    7-30-2013
  • Just How Versatile Is the Polymerase Chain Reaction?
    to the gold standard of culture and histology which requires 24-48 hours for detection. ... periods, all made possible by PCR. PCR is even being used in directed protein evolution. ...
    7-25-2013
  • CRISPR/Cas Comes of Age-Almost
    Four Cas protein families, designated Cas1 to Cas4, are strictly associated with CRISPR ... They also reported detection of off-target alterations induced by four out of six RGNs ...
    7-24-2013
  • Six Websites You Need to Bookmark
    species, interaction ID, detection method, or interaction type, among other options. ... Arabidopsis protein phosphorylation, the PhosPhAt database is an invaluable resource. ...
    7-12-2013
  • HTRF Applications in New Drug Discovery
    ... For example, antihuman Fc detection of a target protein cannot be used when screening human IgGs. A further limitation is the distance required between donor and acceptor to get ...
    7-1-2013
  • Blood-Based Tumor Sequence
    of the tumor containing the mutated protein or pathway, and a reduction of side ... LiquidBiopsy Figure 2. Yield and detection of mutations in breast cancer cells recovered ...
    7-1-2013
  • 10 Minute Charge Heterogeneity Analysis for Development and Quality...
    Determination of protein isoelectric points and charge isoforms are critical steps in ... Automated methods for charge heterogeneity detection such as imaged capillary isolectric ...
    6-19-2013
  • Rapid Mass Analysis of Intact Proteins
    Products Figure 1. Analysis of a large protein, a-2-macroglobulin Chemical analysis is a ... a pivotal role in the detection and quantitation of a vast array of chemical substances. ...
    6-15-2013
  • Top 20 Corporate Venture Funds
    ... novel vaccines technologies, and innovative protein and peptide biotherapeutics. ... addressable markets" through early detection, prevention, and remediation of disease ...
    6-14-2013
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    Journal Articles

  • A Highly Specific Cell-Based High-Throughput Screening Assay...
    Hongxia Wang, Anisia J. Silva, Lynn Rasmussen, E. Lucile White, Jorge A. Benitez
    ASSAY and Drug Development Technologies
    Cyclic Adenosine Monophosphate Receptor Protein in Gram-Negative Bacteria ASSAY and Drug ... release, and subsequent detection of chemical signal molecules called autoinducers. ...
  • Effects of Subinhibitory Concentrations of Antimicrobial Agents...
    Farah J. Nassar, Elias A. Rahal, Ahmad Sabra, Ghassan M. Matar
    Foodborne Pathogens and Disease
    Both strains at the two sub-MICs were also subjected to Western Blotting for LexA protein expression and to Reverse Passive Latex agglutination for Stx detection. For both strains ...
  • Epitope Characterization of Sero-Specific Monoclonal Antibody...
    Cindi R. Corbett, Erin Ballegeer, Kelly A. Weedmark, M.D. Elias, Fetweh H. Al-Saleem, Denise M. Ancharski, Lance L. Simpson, Jody D. Berry
    Hybridoma
    there still exists a need for accurate and sensitive detection capabilities for BoNTs. ... a single MAb, F90G5-3, bound to the whole BoNT/A protein and was characterized further. ...
  • Discovering Small Molecule Ligands of Vascular Endothelial Growth...
    James P. Landry, Yiyan Fei, Xiangdong Zhu, Yaohuang Ke, Guoliang Yu, Pierre Lee
    ASSAY and Drug Development Technologies
    optical detection and small-molecule microarrays (SMM), this platform consists of three assays: (1) the first assay detects binding of a target protein with small ...

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