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Search Results - Post-Translational Modifications
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  • Heightened Characterization of Therapeutic mAbs Using a Novel...
    In particular, deep characterization of glycosylation and other post-translational modifications is required because of their influence on antibody stability, activity, and ...
    5-15-2013
  • Improving Proteomics Approaches
    ... These complexes were for many years believed to be covalent-similar to more common post-translational modifications such as phosphorylation and methylation. Subsequently, the ...
    5-15-2013
  • Mass Spec Provides Peek into PTMs
    Post-translational modifications (PTMs) collectively pertain to a phase in protein biosynthesis that involves changes in a polypeptide chain, resulting in a fully functional ...
    5-15-2013
  • Fluorescence Lifetime Assays
    ... In epigenetics, proteins termed epi-readers (such as the bromodomain-containing family of proteins) are of particular interest, as they recognize post-translational modifications ...
    5-15-2013
  • Glycobiology Analysis Solutions Using HPAE-PAD
    With many biological functions, glycosylation is one of the most important post-translational modifications of eukaryotic cell proteins. Oligosaccharides are covalently attached to ...
    4-18-2013
  • Epigenetics Opens New Avenues for DNA Research
    ... Divalent nickel salts were shown to cause epigenetic changes that include aberrant DNA methylation and post-translational histone modifications, causing changes in chromosomal ...
    4-1-2013
  • The ABCs of Glycoproteins: How to Combine Analytics, Biology...
    This webinar will benefit: Biochemists who identify and characterize biotherapeutic proteins Discovery scientists analyzing post-translational modifications of proteins Development ...
    3-15-2013
  • Plant-Based Protein Biomanufacturing
    Specific kinds of eukaryotic post-translational modifications-such as glycosylation-must also be considered. Target yield is important in designing a protein expression project. ...
    2-15-2013
  • Epigenetics: Promising Field Delivers
    Previously, it was proposed that histone post-translational modifications were the ones responsible for epigenetic inheritance, but to a large extent these models were based on ...
    1-15-2013
  • Eliminating Biological Change after Excision
    Understanding the role of proteins, peptides, and their post-translational modifications in the metabolism of healthy and diseased tissue is crucial to elucidate biological ...
    1-15-2013
  • Cevec Inks Another Cell-Line Licensing Agreement
    These nontumor origin cell lines exhibit high protein expression, have been adapted to serum-free suspension culture, and show post-translational modifications that are human-like, ...
    12-20-2012
  • Epigenetics Reshapes the Therapeutic Arena
    ... modifications that occur on histones," says Bernd Hentsch, Ph.D., CDO at 4SC. Recent years witnessed two major advancements relevant to histone post-translational modifications. ...
    12-1-2012
  • Optimizing Cell Lines Improves Production-Really!
    ... our technology, to material from a stable cell line, and found no detectable differences in intactness, aggregation, charge, or post-translational modifications," he pointed out. ...
    11-15-2012
  • Protein Production Prowess Progresses
    Their efforts can be thwarted by problems ranging from incomplete control over cells' growth conditions to inadequate post-translational modifications. However, progress is being ...
    11-1-2012
  • Using MS to Assess Biotherapeutic Quality
    Including post-translational modifications, the human proteome is estimated to contain more than 100,000 distinct proteins. Typical LC-MS experiments of human plasma and serum can ...
    11-1-2012
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    Journal Articles

  • Microarrays as Validation Strategies in Clinical Samples: Tissue...
    Adriana Aguilar-Mahecha, Saima Hassan, Cristiano Ferrario, Mark Basik
    OMICS: A Journal of Integrative Biology
    cell lysates or, more recently, plasma or serum samples, which can be assayed for protein quantity and for the presence of post-translational modifications such as phosphorylation. ...
  • Carbohydrate Microarrays: Survey of Fabrication Techniques
    Adrian S. Culf, Miroslava Cuperlovic-Culf, Rodney J. Ouellette
    OMICS: A Journal of Integrative Biology
    This postgenomic activity is necessary because of the complexity of protein biosynthesis and post-translational modifications that cannot currently be detected at the genome level. ...
  • Proteomic and Phosphoproteomic Analyses of the Soluble Fraction...
    Anshu Chen, Melanie L. McEwen, Shixin Sun, Rangaswamyrao Ravikumar, Joe E. Springer
    Journal of Neurotrauma
    or both in response to SCI. Protein redundancies among the gel spots were likely due to differences in proteolysis, post-translational modifications, and the existence of isoforms. ...
  • Polyclonal Antibodies Against Human Proteasome Subunits PSMA3...
    Veronika A. Livinskaya, Vadim A. Ivanov, Olga A. Fedorova, Daria N. Vorontsova, Nick A. Barlev, Andrey A. Nikiforov
    Hybridoma
    and/or overexpressed proteasome subunits, which facilitates subsequent analysis of their post-translational modifications as well as protein-protein interactions in vivo.

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