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  • Molecular Imaging Driving Development
    ... hinder efforts to determine pharmacodynamics and pharmacokinetics in preclinical models. ... in the combined measurement of pharmacodynamics and pharmacokinetics in cancer xenografts. ...
    8-1-2013
  • PolyTherics Expands Drug Development Services with Antitope Purchase
    stable and homogeneous antibody-drug conjugates, technologies to optimize the pharmacokinetics of biologics, technologies for immunogenicity screening, technologies to ...
    7-26-2013
  • Across Pharma, Few Open Arms for Trial Data Sharing
    modifications companies can apply to their compounds to improve their metabolism, pharmacokinetics, or safety, without divulging confidential information about those structures. ...
    7-8-2013
  • Single-Molecule Counting and Monitoring
    Singulex customers are using the platform to evaluate therapeutic safety and efficacy, as well as pharmacokinetics and pharmacodynamics, among other things. Erenna includes a ...
    7-1-2013
  • Reducing the Cost of Peptide Synthesis
    ... Companies are even taking another look at "old" peptide drug candidates that may have been put on the shelf due to poor pharmacokinetics or bioavailability. Manufacturing these ...
    7-1-2013
  • Roche, AstraZeneca to Share Some Drug Design Data
    The technology identifies modifications that companies can apply to the structures of their compounds to improve their metabolism, pharmacokinetics, or safety, without divulging ...
    6-26-2013
  • Basilea Wins Up to $89M BARDA Contract to Develop New Antibiotic
    The trial and studies are both intended to assess the pharmacokinetics, safety, and tolerability of BAL30072. For the current multiple ascending-dose study, the maximum tolerated ...
    6-25-2013
  • Metabolomics-Young Field, Bright Future
    ... Tcherpakov says, the most prominent applications are for "toxicology and safety assessments, drug metabolism studies for pharmacokinetics, and biomarker discovery for monitoring or ...
    6-25-2013
  • Caution: Falling Job Zone
    ... compensation. "We need more scientists in development, people that understand pharmacokinetics, pharmacodynamics, toxicology, pharmacology, process development, process ...
    6-14-2013
  • Novo Nordisk Reports Promising Phase III Results for Hemophilia...
    The paradigm trials consist of seven studies designed to investigate the pharmacokinetics, immunogenicity, efficacy, and safety of N9-GP in adult and pediatric hemophilia B ...
    5-17-2013
  • Harnessing the Power of Kinase Inhibitors
    ... Pharmacokinetics of a selection of compounds has further been evaluated by oral and intravenous administration in mice, and these tyrosine kinase inhibitors demonstrate high plasma ...
    5-8-2013
  • Ethical Considerations in Phase II Trials
    Using enrichment designs, pharmacodynamics, or real-time pharmacokinetics all entail more frequent (and often invasive) tissue collection from volunteers. In areas of vaccine ...
    5-7-2013
  • Biosimilars: 10 Drugs to Watch
    ... 2012, to study the safety and pharmacokinetics of the biosimilar compared to Herceptin. ... studying the biosimilar's safety and pharmacokinetics compared to Humira (adalimumab) in ...
    4-22-2013
  • BMS, Vertex Plan Phase II Studies of Hep C Combo Therapy
    tolerability, pharmacokinetics, and viral cure rates (SVR4 and SVR12) of multiple all-oral regimens of VX-135 and daclatasvir dosed once daily, pending regulatory discussions. ...
    4-5-2013
  • Xceleron and JCL Bioassay Partner in Early Clinical Investigations
    The company works with human microdose and microtracer techniques using ultra-sensitive AMS to investigate the pharmacokinetics and metabolism of developmental drugs in Phase 0, ...
    3-19-2013
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    Journal Articles

  • A Prospective Multicenter Phase 1 Matched Comparison Group Trial...
    Robert George Grossman, Michael Fehlings, Ralph Frankowski, Keith D. Burau, Diana Chow, Charles Tator, Yang Teng, Elizabeth Gardiner Toups, James Shields Harrop, Bizhan Aarabi, Christopher Shaffrey, Michele M. Johnson, Susan Harkema, Maxwell Boakye, James Guest, Jefferson R. Wilson
    Journal of Neurotrauma
    A Prospective Multicenter Phase 1 Matched Comparison Group Trial of Safety, Pharmacokinetics, and Preliminary Efficacy of Riluzole in Patients with Traumatic Spinal Cord Injury ...
  • Emerging Trends for Radioimmunotherapy in Solid Tumors
    Maneesh Jain, Suprit Gupta, Sukhwinder Kaur, Moorthy P. Ponnusamy, Surinder K. Batra
    Cancer Biotherapy and Radiopharmaceuticals
    Poor tumor uptake and undesirable pharmacokinetics, however, have precluded the administration of radioimmunoconjugates at therapeutically relevant doses thereby limiting the ...
  • Pharmacokinetics of Recombinant Murine Interferon-γ in Mice
    INGE RUTENFRANZ, HOLGER KIRCHNER
    Journal of Interferon & Cytokine Research
    Pharmacokinetics of Recombinant Murine Interferon-γ in Mice Journal of Interferon & Cytokine Research
  • Pharmacokinetics and Tissue Distribution of 14 C-Labeled Grape...
    Elsa M. Janle, Mary Ann Lila, Michael Grannan, Lauren Wood, Aine Higgins, Gad G. Yousef, Randy B. Rogers, Helen Kim, George S. Jackson, Lap Ho, Connie M. Weaver
    Journal of Medicinal Food
    Pharmacokinetics and Tissue Distribution of 14 C-Labeled Grape Polyphenols in the Periphery and the Central Nervous System Following Oral Administration Journal of Medicinal Food

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