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  • Roche Signs Up to $422.5M Collaboration with Inovio
    A Phase I study combining the drug candidate with Avastin (bevacizumab) plus Folfox in patients with advanced solid tumors. A Phase I safety, tolerability, and pharmacokinetics ...
    9-10-2013
  • Rhythm Awarded $1.35M from Michael J. Fox Foundation
    Derived from the natural ghrelin sequence, RM-131 has been optimized to stimulate gastrointestinal motility, with greater potency and enhanced stability and pharmacokinetics, ...
    9-10-2013
  • MacroGenics Received $10M Milestone from Servier
    The dose expansion portion of this study is designed to further evaluate safety and pharmacokinetics at a weekly dose of 15 mg/kg. It includes an early evaluation of the potential ...
    8-20-2013
  • FDA Approves Viiv Healthcare's HIV-1 Treatment Tivicay
    Viiv also submitted data from a fifth trial that established the pharmacokinetics, safety, and activity of Tivicay as part of treatment regimens for HIV-infected children 12 and up ...
    8-13-2013
  • Molecular Imaging Driving Development
    ... hinder efforts to determine pharmacodynamics and pharmacokinetics in preclinical models. ... in the combined measurement of pharmacodynamics and pharmacokinetics in cancer xenografts. ...
    8-1-2013
  • PolyTherics Expands Drug Development Services with Antitope Purchase
    stable and homogeneous antibody-drug conjugates, technologies to optimize the pharmacokinetics of biologics, technologies for immunogenicity screening, technologies to ...
    7-26-2013
  • Across Pharma, Few Open Arms for Trial Data Sharing
    modifications companies can apply to their compounds to improve their metabolism, pharmacokinetics, or safety, without divulging confidential information about those structures. ...
    7-8-2013
  • Single-Molecule Counting and Monitoring
    Singulex customers are using the platform to evaluate therapeutic safety and efficacy, as well as pharmacokinetics and pharmacodynamics, among other things. Erenna includes a ...
    7-1-2013
  • Reducing the Cost of Peptide Synthesis
    ... Companies are even taking another look at "old" peptide drug candidates that may have been put on the shelf due to poor pharmacokinetics or bioavailability. Manufacturing these ...
    7-1-2013
  • Roche, AstraZeneca to Share Some Drug Design Data
    The technology identifies modifications that companies can apply to the structures of their compounds to improve their metabolism, pharmacokinetics, or safety, without divulging ...
    6-26-2013
  • Basilea Wins Up to $89M BARDA Contract to Develop New Antibiotic
    The trial and studies are both intended to assess the pharmacokinetics, safety, and tolerability of BAL30072. For the current multiple ascending-dose study, the maximum tolerated ...
    6-25-2013
  • Metabolomics-Young Field, Bright Future
    ... Tcherpakov says, the most prominent applications are for "toxicology and safety assessments, drug metabolism studies for pharmacokinetics, and biomarker discovery for monitoring or ...
    6-25-2013
  • Caution: Falling Job Zone
    ... compensation. "We need more scientists in development, people that understand pharmacokinetics, pharmacodynamics, toxicology, pharmacology, process development, process ...
    6-14-2013
  • Novo Nordisk Reports Promising Phase III Results for Hemophilia...
    The paradigm trials consist of seven studies designed to investigate the pharmacokinetics, immunogenicity, efficacy, and safety of N9-GP in adult and pediatric hemophilia B ...
    5-17-2013
  • Harnessing the Power of Kinase Inhibitors
    ... Pharmacokinetics of a selection of compounds has further been evaluated by oral and intravenous administration in mice, and these tyrosine kinase inhibitors demonstrate high plasma ...
    5-8-2013
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    Journal Articles

  • Pharmacokinetics and Pharmacodynamics in HIV Prevention: Current...
    Joseph Romano, Angela Kashuba, Stephen Becker, James Cummins, Jim Turpin, Fulvia Veronese, on Behalf of the Antiretr
    AIDS Research and Human Retroviruses
    Pharmacokinetics and Pharmacodynamics in HIV Prevention: Current Status and Future Directions: A Summary of the DAIDS and BMGF Sponsored Think Tank on Pharmacokinetics (PK)/...
  • Pharmacokinetics of Saquinavir Hard-Gel/Ritonavir and Atazanavir...
    Marta Boffito, Desmond Maitland, Laura Dickinson, David Back, Andrew Hill, Carl Fletcher, Graeme Moyle, Mark Nelson, Brian Gazzard, Anton Pozniak
    AIDS Research and Human Retroviruses
    Pharmacokinetics of Saquinavir Hard-Gel/Ritonavir and Atazanavir When Combined Once Daily ... AIDS Research and Human Retroviruses The pharmacokinetics and short-term safety of ...
  • Pharmacokinetics and Tumor Localization of 111 In-Labeled HuCC49ΔC...
    Paul C. Chinn, Ron A. Morena, Denise A. Santoro, Timothy Kazules, Syed V.S. Kashmiri, Jeffrey Schlom, Nabil Hanna, Gary Braslawsky
    Cancer Biotherapy and Radiopharmaceuticals
    Pharmacokinetics and Tumor Localization of 111 In-Labeled HuCC49ΔC H 2 in BALB/c Mice and ... We compared the pharmacokinetics and tumor uptake of 111In-HuCC49?CH2 in BALB/c mice and a ...
  • Pharmacokinetics and Clinical Evaluation of 125 I-Radiolabeled...
    Jim Xiao, Sara Horst, George Hinkle, Xianhua Cao, Ergun Kocak, Jing Fang, Donn Young, M. Khazaeli, Doreen Agnese, Duxin Sun, Edward Martin
    Cancer Biotherapy and Radiopharmaceuticals
    Pharmacokinetics and Clinical Evaluation of 125 I-Radiolabeled Humanized CC49 Monoclonal ... This study examined the pharmacokinetics and tissue localization of a humanized ...

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