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  • Novo Nordisk Reports Promising Phase III Results for Hemophilia...
    The paradigm trials consist of seven studies designed to investigate the pharmacokinetics, immunogenicity, efficacy, and safety of N9-GP in adult and pediatric hemophilia B ...
    5-17-2013
  • Harnessing the Power of Kinase Inhibitors
    ... Pharmacokinetics of a selection of compounds has further been evaluated by oral and intravenous administration in mice, and these tyrosine kinase inhibitors demonstrate high plasma ...
    5-8-2013
  • Ethical Considerations in Phase II Trials
    Using enrichment designs, pharmacodynamics, or real-time pharmacokinetics all entail more frequent (and often invasive) tissue collection from volunteers. In areas of vaccine ...
    5-7-2013
  • Biosimilars: 10 Drugs to Watch
    ... 2012, to study the safety and pharmacokinetics of the biosimilar compared to Herceptin. ... studying the biosimilar's safety and pharmacokinetics compared to Humira (adalimumab) in ...
    4-22-2013
  • BMS, Vertex Plan Phase II Studies of Hep C Combo Therapy
    tolerability, pharmacokinetics, and viral cure rates (SVR4 and SVR12) of multiple all-oral regimens of VX-135 and daclatasvir dosed once daily, pending regulatory discussions. ...
    4-5-2013
  • Xceleron and JCL Bioassay Partner in Early Clinical Investigations
    The company works with human microdose and microtracer techniques using ultra-sensitive AMS to investigate the pharmacokinetics and metabolism of developmental drugs in Phase 0, ...
    3-19-2013
  • Jump-Starting Phase I Clinical Investigations
    Thoroughly understanding the pharmacokinetics of a drug or biologic in clinical Phase I studies allows investigators to make decisions earlier, according to Geoffrey Banks, Ph.D., ...
    2-26-2013
  • Cangene Inks $300+M Deal for Bankrupt Inspiration's IB1001
    The clinical hold impacts a Phase III study of IB1001 in previously treated pediatric subjects with hemophilia B, designed to measure the drug candidate's pharmacokinetics, safety, ...
    2-20-2013
  • Improving In Vivo Small Animal Imaging
    ... can capture signals from 400 nm into the near-IR range of 700-900 nm, enabling the use of fluorescently tagged antibodies or drugs for biodistribution and pharmacokinetics studies. ...
    2-1-2013
  • Challenging the Limits of Protein Characterization
    ... And the third is to use the inhalation route to treat a systemic disorder, to alter the pharmacokinetics (for pain relief, for example) or pharmacodynamics, or to avoid ...
    2-1-2013
  • Biological Sample Card Punching
    reference databasing as well as preclinical and clinical drug metabolism, pharmacokinetics, and toxicology studies. The easyPunch workstation is based on the Microlab® ...
    2-1-2013
  • Novartis Ends Nicotine Addiction Vaccine Project
    study with NIC002 performed with 65 smokers that aims to assess how nicotine antibodies, induced by vaccination, affect the pharmacokinetics of nicotine during cigarette smoking. ...
    1-23-2013
  • Biggest Biotech Trends of 2012
    product with respect to structure, function, animal toxicity, human pharmacokinetics and pharmacodynamics, clinical immunogenicity, and clinical safety and effectiveness." ...
    1-15-2013
  • Development of Cytokine Biomarker & Immunogenicity Assays
    ... Generation of antidrug antibodies in a patient can have a profound impact on the pharmacokinetics, pharmacodynamics, efficacy, and safety of a therapeutic. The type and severity of ...
    1-1-2013
  • Biggest Biotech Trends of 2012
    with respect to structure, function, animal toxicity, human pharmacokinetics (PK) and pharmacodynamics (PD), clinical immunogenicity, and clinical safety and effectiveness." ...
    12-26-2012
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    Journal Articles

  • Impaired Pharmacokinetics of Levothyroxine in Severely Obese...
    Marina A. Michalaki, Margarita I. Gkotsina, Irene Mamali, Georgios K. Markantes, Amalia Faltaka, Fotios Kalfarentzos, Apostolos G. Vagenakis, Kostas B. Markou
    Thyroid
    Impaired Pharmacokinetics of Levothyroxine in Severely Obese Volunteers Thyroid Background: Suppressive or replacement doses of levothyroxine (LT4) are affected by the rate and ...
  • Pharmacodynamic Performance of Tigecycline versus Common Intravenous...
    Joseph L. Kuti, Michael Dowzicky, David P. Nicolau
    Surgical Infections
    infusion model was used to simulate steady-state concentrations for common dosages of these antibiotics. Population pharmacokinetics data from infected patients were employed. ...
  • Pharmacodynamic Modeling of Imipenem-Cilastatin, Meropenem, and...
    Christine T. Ong, Joseph L. Kuti, David P. Nicolau
    Surgical Infections
    The pharmacokinetics for each antibiotic were derived from previously published healthy volunteer studies. The MICs for Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia ...
  • Sex and Racial Differences in Pharmacological Response: Effect...
    Maureen D. Donovan
    Journal of Women's Health
    Sex and Racial Differences in Pharmacological Response: Effect of Route of Administration and Drug Delivery System on Pharmacokinetics Journal of Women's Health Mechanistic ...

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