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  • Companion Diagnostics: 52 Pick-Up
    ... which has been designated an orphan drug by FDA and EMA. Financial terms not disclosed. ... Specific drugs and cancer indications undisclosed. Diagnostics will apply Qiagen's ...
    5-9-2013
  • Pfizer, Alberta Renew Funding for Translational Research
    to identify which cancer patients will develop a resistance to certain chemotherapy drugs. ... to the consequences of diabetes; and orphan and genetic diseases. "Alberta has a ...
    4-25-2013
  • Report: Orphan Drugs Cheaper to Bring to Market, Offer Better...
    Worldwide orphan drug sales are slated to reach $127 billion by 2018, according to an EvaluatePharma® report released today. Excluding generics, orphan drugs are expected to make ...
    4-22-2013
  • Exploiting Folate Pathways to Treat Cancer
    ... The EMA granted vintafolide the equivalence of orphan drug status in March 2012, because ... Modular Warheads SMDCs for other types of cancer are made by attaching different drugs, or ...
    4-1-2013
  • Edison Will Receive Up To $525M in Mitochondrial and CNS Disease...
    The initial scope of the transaction includes both pediatric orphan inherited ... that enable the discovery, optimization, and clinical validation of redox-directed drugs. ...
    3-28-2013
  • Biopharmas Cooling to Licensing Deals as Patent Cliff Fears Ease
    One area where licensing and M&A activity could increase this year, Urquhart said, is orphan drugs, whose development costs are lower than for many other disease categories, and ...
    3-28-2013
  • NPS Buys Teduglutide, PTH 1-84 Rights from Takeda for Up to ...
    The deal comes as NPS prepares to launch teduglutide, an orphan drug for adult short bowel ... to finalize our commercial strategy for both drugs to maximize their worldwide success." ...
    3-19-2013
  • Receptos Licenses AbbVie Antibody for Co-Development
    Financial terms were not disclosed. Receptos, a San Diego developer of drugs for immune ... RPC4046 in eosinophilic esophagitis (EoE), an FDA-designated orphan disease indication. ...
    3-13-2013
  • Genome Editing for R&D and Therapeutics
    ... us that cancer is essentially hundreds of orphan diseases, comprised of multiple subtypes ... mutations for screening drugs to treat or prevent Alzheimer's disease," he points out. ...
    3-1-2013
  • Small Firms Look Optimistically to Future
    medicine for specialty markets-not drugs that are merely wanted, but drugs that are ... fibrosis. In November, the FDA granted orphan drug status to AeroVanc(tm), a vancomycin ...
    3-1-2013
  • Distributed Computing Meets Drug Discovery
    time toward discovering and investigating new small molecules for drugs to fight diseases. ... The foundation will focus primarily on orphan and rare diseases as it builds its ...
    2-28-2013
  • Plant-Based Protein Biomanufacturing
    For us, expression in rice meets these specific requirements, whereas products needed on a much smaller scale (e.g., orphan drugs) might be adequately served by other platforms. ...
    2-15-2013
  • FDA Blocks Novo, Boosts Celgene
    ... Kyprolis (carfilzomib). Both drugs were reviewed through FDA's accelerated approval program, while Pomalyst was also granted orphan product designation because it is ...
    2-11-2013
  • Alnylam Losses Widened by Tekmira Settlement
    ... The company also cited its new ALN-AS1 program for the rare orphan disease acute ... lawsuits over LNP technology for RNAi drugs. Alnylam Losses Widened by Tekmira ...
    2-8-2013
  • Pioneering Antisense Drug Gets FDA Approval
    injection as an adjunct to lipid-lowering drugs and diet to reduce low-density ... HoFH is an orphan indication linked to high cholesterol levels leading to heart attacks ...
    1-30-2013

  • Journal Articles

  • A Family of Fatty Acid Binding Receptors
    Andrew J. Brown, Steven Jupe, Celia P. Briscoe
    DNA and Cell Biology
    for almost a third of currently marketed drugs, and provides the predominant mechanism ... the physiological ligands for these "orphan" receptors and revealing new drug targets. ...
  • Coactivators in Assay Design for Nuclear Hormone Receptor Drug...
    Taosheng Chen, Wen Xie, Michele Agler, Martyn Banks
    ASSAY and Drug Development Technologies
    of ligands for orphan NHRs, will lead to new therapies for many human diseases. Many pharmaceutical companies are investing in NHR-targeted drugs, which are estimated to ...

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