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Search Results - Oligonucleotides
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  • Making Vaccines from Parts
    A custom software program calculated the sequences of needed oligonucleotides to build the gene sequences. From there, the genes were built enzymatically in cell-free reactions ...
    5-14-2013
  • TIDES: Oligonucleotides and Peptide Therapeutics From Research...
    Boston MA UNITED STATES http://bit.ly/XSQL61
    5-12-2013
  • Critical Tools for Oligo Characterization
    Oligonucleotides were almost nonexistent in major pharmacopoeias at the time. Now that ... LC/MS is not as routine or straightforward for oligonucleotides, whose synthesis creates a ...
    5-1-2013
  • Biosearch Moving into New Digs for GMP Production
    Biosearch Technologies, a company that specializes in the development and manufacture of GMP-grade oligonucleotides, is moving its GMP manufacturing process into a new GMP ...
    4-18-2013
  • Advances in RNAi Tools and Technologies
    miRNA inhibitors are single-stranded oligonucleotides (with heavy chemical modifications) ... Diehl explains that Cellecta uses a synthesized pool of oligonucleotides to make a library ...
    4-15-2013
  • Development and Evolution of PCR
    ... is the use of "aptamers," small oligonucleotides that have been selected in vitro to ... energy transfer between two annealed oligonucleotides, have also been used in real-time ...
    4-1-2013
  • DNA to Hang Your Hat On
    ... The Karolinska team uses a long single-stranded DNA molecule or scaffold, and then mixes the scaffold with about 200 short, single-stranded oligonucleotides, or staples. As all of ...
    3-20-2013
  • Next-Gen Gene Synthesis Opens a World of New Possibilities
    ... DNA? Church: Gen9 is the only company that I know of actually delivering diverse sets of large DNA constructs assembled from oligonucleotides chemically synthesized on chips. ...
    3-4-2013
  • Biosearch Eyes Europe Growth with Two Acquisitions
    The acquisition will enable DNA Technology, a producer of custom-manufactured synthetic oligonucleotides in Nordic countries, to expand production capabilities and product ...
    2-20-2013
  • Targeting Protein-Protein Interactions
    ... The technology uses chemical building blocks linked to bispecific DNA oligonucleotides via cleavable and noncleavable linkers and exploits the self-assembly of the oligonucleotides ...
    2-15-2013
  • Epigenetics: Promising Field Delivers
    ... This strategy, which can be adapted to other experimental settings, involves the synthesis of tens of thousands of tagged oligonucleotides that contain a library of regulatory ...
    1-15-2013
  • The Buzz at ASHG
    The NimbleGen SeqCap EZ Exome + UTR library contains 2.1 million empirically optimized long oligonucleotides in solution, which includes 64 Mb of coding exons and miRNA regions and ...
    1-15-2013
  • 4 Tips to Avoid Cloning Deletions
    PCR amplicons are commonly used for cloning. Primers made from synthetic oligonucleotides often contain a small percentage of incorrect sequences which, combined with ligation and ...
    12-14-2012
  • Novel Applications for Systems Biology
    ... Musso accomplished this in a machine-learning framework using known, published gene-phenotype associations of morpholino (antisense oligonucleotides used to inhibit specific ...
    12-1-2012
  • Lucky 13 Serial Entrepreneurs
    ... Dharmacon -Scientific co-founder; Executive VP for Research and Operations and General Manager. Company founded 1995 to provide RNA oligonucleotides, small interfering RNA (siRNA), ...
    11-12-2012
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    Journal Articles

  • High-Throughput Tracking of Pluripotent Human Embryonic Stem...
    Frank W. King, Walter Liszewski, Carissa Ritner, Harold S. Bernstein
    Stem Cells and Development
    Molecular beacons are single-stranded oligonucleotides that have been employed to assay gene expression. To test their potential for high-throughput isolation of hESCs, we ...
  • Addition of the Immunostimulatory Oligonucleotide IMT504 to a...
    Alejandro Daniel Montaner, Analía DeNichilo, Juan Manuel Rodríguez, Juan Fló, Ricardo Agustin López, Andrea Pontoriero, Vilma Savy, Elsa Baumeister, Ronald Frank, Jorge Zorzopulos, Fernanda Elías
    Nucleic Acid Therapeutics
    Flu vaccines are partially protective in infants and elder people. New adjuvants such as immunostimulatory oligonucleotides (ODNs) are strong candidates to solve this problem, ...
  • Purification of Small Interfering RNA Using Nondenaturing Anion...
    Bernhard Noll, Stephan Seiffert, Frank Hertel, Harald Debelak, Philipp Hadwiger, Hans-Peter Vornlocher, Ingo Roehl
    Nucleic Acid Therapeutics
    A manufacturing and purification process for duplex oligonucleotides was established, which shortens and simplifies currently used procedures, yielding a product of higher purity. ...
  • Acute Molecular Perturbation of Inducible Nitric Oxide Synthase...
    Dominic M. Maggio, Katina Chatzipanteli, Neil Masters, Samik P. Patel, W. Dalton Dietrich, Damien D. Pearse
    Journal of Neurotrauma
    administration of iNOS antisense oligonucleotides (ASOs) 3 hours after moderate, ... alone, SCI and mixed base control oligonucleotides (MBOs) or SCI and iNOS ASOs (200nM). ...

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