Current Issue

View Larger Image

Past Issues Free Subscriptions
Sponsored
Keywords



Search Results - Mouse Models
 More »

  • Altered Receptor Allows Tumors to Sneak by Immune System
    Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β receptor (TGFBR3) in tumors promotes cancer progression by altering signaling in ...
    8-9-2013
  • Ban Sunburn Pain without Coppertone
    The study, which was conducted in mouse models and human skin samples, could yield a way to combat sunburn and possibly several other causes of pain, note the investigators. ...
    8-6-2013
  • Molecular Imaging Driving Development
    ... pharmacodynamics and pharmacokinetics in preclinical models. Speaking with GEN, Dr. ... an axial FATSAT T1W MRI image (A) of a mouse tumor (red outline) and corresponding ...
    8-1-2013
  • Improving Preclinical Research
    ... No matter how closely mouse models of disease recapitulate human phenotypes, a mouse is a mouse and a person is not. As Dr. Kimmelman and his colleagues note in their paper, ...
    7-29-2013
  • CRISPR/Cas Comes of Age-Almost
    The scientists built multiple sequence alignments and hidden Markov models for 45 Cas ... short RNAs to induce precise cleavage at endogenous genomic loci in human and mouse cells. ...
    7-24-2013
  • Abide, UCSD to Validate Alzheimer's Therapeutic Target with Foundation...
    inhibitor's ability to delay or prevent disease progression in a mouse model of Down syndrome. Such models "exhibit similar abnormalities in brain structure and cognition ...
    7-16-2013
  • Biogen Idec, Myelin Repair Foundation Eye New Mouse Model Against...
    Also, the DTA model displays characteristics reminiscent of the progressive form of MS, not yet available in other mouse models. By contrast, the most commonly used models for MS ...
    7-1-2013
  • Stem Cell Science Advances
    ... differentiation approach to drive mouse ESCs toward a cardiomyocyte lineage, and ... People will make patient-specific models for brain diseases, for hepatic metabolism, for ...
    6-11-2013
  • Cancer: Why Some Stem Cells Cause Tumors
    Turning to mathematical and mouse models, the team, led by Cambridge's David Kent, Ph.D., deconstructed a cellular mechanism that operates in stem cells, though not their progeny. ...
    6-4-2013
  • Strategies to Optimize Cell Culture
    in the raw material and run the small-scale models and see what the impact is." ... Sialic Acid Content Analysis Multiple 3D cell spheroids generated from mouse embryonic ...
    6-1-2013
  • Crowdfunding Touches Down in Biotech
    different models toward raising money for biopharmas and researchers, respectively. ... Elizabeth Iorns, Ph.D., is seeking $15,000 toward a mouse model of a noninvasive method of ...
    5-15-2013
  • Companion Diagnostics: 52 Pick-Up
    ... Intended Use/Indications for Use: Mouse monoclonal antibody intended for ... OncoMed's proprietary xenograft models derived from freshly resected human cancers. ...
    5-9-2013
  • Harnessing the Power of Kinase Inhibitors
    ... or systematic knockouts in animal models, have not been very fruitful when it ... The in vivo model induced inflammation in the mouse lung to mimic an asthmatic response. ...
    5-8-2013
  • Stem Cell Model of Neurodegenerative Disease Elucidates Potential...
    A-T is caused by lost function in a gene, ATM, which normally repairs damaged DNA in the cells and preserves normal function. Although mouse models are commonly used to study A-T, ...
    5-7-2013
  • The Tumor Microenvironment as a Drug Target, Part II
    reported they had developed computer models to analyze breast cancer microscopic images. ... metastasis by breast tumor cells in a mouse xenograft model through direct inhibition ...
    5-7-2013
  • More »

    Journal Articles

  • Enhanced Autoimmunity Associated with Induction of Tumor Immunity...
    Suresh Kari, Jeffrey C. Flynn, Muhammad Zulfiqar, Daniel P. Snower, Bruce E. Elliott, Yi-chi M Kong
    Thyroid
    breast cancer models in mice resistant to experimental autoimmune thyroiditis (EAT). ... Tumor growth was monitored 3x/week by palpation. Subsequent EAT induction was by mouse ...
  • Immunotherapy Trials for Type 1 Diabetes: The Contribution of...
    Jay S. Skyler, Alberto Pugliese
    Diabetes Technology & Therapeutics
    autoantibody assays and predictive models (which included metabolic testing and ... Moreover, George identified and tested in the mouse small molecules that block or modulate ...
  • Monoclonal Antibody Selectively Recognizing Murine But Not Human...
    Yumi Kinugasa, Nobuyuki Takakura
    Hybridoma
    mouse but not human CD44 in flow cytometry. Thus, this antibody provides an effective tool to analyze CD44 from host (mouse) cells in human cancer cell xenograft models in mice.
  • Modeling Susceptible Infective Recovered Dynamics and Plague...
    Patrick Foley, Janet Foley
    Vector-Borne and Zoonotic Diseases
    Deterministic Susceptible Infective Recovered (SIR) models were adapted for plague and ... This included the vole Microtus californicus, the deer mouse Peromyscus maniculatus, the ...

GEN Webinars

View »

GEN Web Briefs

View »

GEN Poll

More » Poll Results » Archive »

Top Paid Women in Biopharma

Do you think the women on our list of the 20 top paid women executives in biopharma are underpaid?

Suggest a Poll