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  • Pharma Touting Phase II/III Wins in Run-Up to ASCO
    ... selumetinib, a selective MEK kinase inhibitor, in patients with advanced uveal melanoma. ... its Yervoy® (ipilimumab) in patients with metastatic melanoma, the company said. ...
    5-16-2013
  • Companion Diagnostics: 52 Pick-Up
    ... human melanoma tissue. Real-time PCR test intended to assist in selecting melanoma patients whose tumors carry the BRAF V600E mutation for treatment with vemurafenib. ...
    5-9-2013
  • Somatic Mutation Links Port-Wine Birthmarks, SWS, and Melanoma...
    Notably, the GNAQ gene is the same gene that causes uveal (intraocular) melanoma, a type of melanoma that occurs in the middle layer of the wall of the eye. The research is ...
    5-8-2013
  • Cancer Diagnostics, Pushing the Boundaries
    ... Loss of PTEN function has been associated with multiple cancers, including endometrial cancer, glioblastoma, melanoma, and prostate cancer. Loss of PTEN activity can result from ...
    5-8-2013
  • BMS Shores Up R&D after Trial Failure, Plavix Patent Loss
    R&D fared much better, however, in successfully developing the anticancer drug Yervoy® (ipilimumab), approved by FDA in 2011 for late-stage metastatic melanoma, and Eliquis®, ...
    4-8-2013
  • Ambry, Illumina Launch FFPE Somatic Variant Profiling Services
    The offering is focused on clinically actionable mutations implicated in solid tumors with a focus on lung, colon, melanoma, gastric, and ovarian cancers. The assay covers relevant ...
    4-5-2013
  • Development and Evolution of PCR
    ... In some cases, the assay is co-developed with the drug and is known as a companion diagnostic (e.g., Zelboraf, which targets melanoma tumors harboring the BRAF V600E mutation). The ...
    4-1-2013
  • Ziopharm Restructuring After Phase III Failure
    The lead therapeutic candidate, Ad-RTS IL-12, is now being tested in two Phase II studies-one for advanced melanoma, and the other for nonresectable recurrent or metastatic breast ...
    3-26-2013
  • Amgen Melanoma Drug Meets Phase III Endpoint
    and efficacy against later stages of melanoma compared to subcutaneous ... TVEC represents a new class of therapy against melanoma because it combines local with ...
    3-20-2013
  • Nucleic Acid Sample Preparation in MDx
    In this case, nests of melanoma cells have been specifically isolated from a skin biopsy. ... study of formalin-fixed paraffin-embedded patient melanoma tissues," Dr. Tackett explains. ...
    3-1-2013
  • Tumor Bank Lends Expertise to Drug Firms
    ... V600E mutation found in ~50% of melanoma patients and 15% of colorectal cancer patients. ... Zelforaf(tm) (vemurafenib) for treating melanoma patients with the BRAF V600E mutation. ...
    2-1-2013
  • Teva Parts Ways with CureTech, Takes $109M Hit
    ... II study for colorectal cancer, and launch a third Phase II study in metastatic melanoma. ... colon cancer, metastatic melanoma, and additional investigator initiated studies." ...
    1-31-2013
  • A "Very Good Year" for Roche
    Zelboraf® for BRAF V600 mutation-positive metastatic melanoma rang up its first sales in ... The growth rate of Zelboraf reflects the high unmet need in metastatic melanoma," Roche ...
    1-30-2013
  • Virotherapy as a Key to Cancer Treatment
    ... encoding GM-CSF and undergoing Phase III testing in both melanoma and head & neck cancer. ... I studies in squamous cell carcinoma of the head and neck, and in malignant melanoma. ...
    1-2-2013
  • The New Economics of Orphan Diseases
    ... indications that are actually sub-populations of larger nonrare diseases, such as BRAF mutated melanoma and ALK-translocated NSCLC," Dr. Meekings says. Oncology is a good example. ...
    1-1-2013
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    Journal Articles

  • Lumbosacral Spondylodiscitis after Sacral Colpopexy of a Sigmoid...
    Anna Voelker, Michael Hoeckel, Christoph-Eckhard Heyde
    Surgical Infections
    Neovagina in a Patient with Vaginal Melanoma Surgical Infections Background: ... undergone multiple gynecological surgeries because of a malignant melanoma of the vagina. ...
  • Laparoscopic Adrenalectomy: Lessons Learned from 306 Cases
    Tomislav Kulis, Nikola Knezevic, Marijeta Pekez, Darko Kastelan, Marija Grkovic, Zeljko Kastelan
    Journal of Laparoendoscopic& Advanced Surgical Techniquesand Part B, Videoscopy
    (n=22), cyst (n=9), myelolipoma (n=9), hemangioma (n=3), ganglioneuroma (n=3), and melanoma (n=2). Conclusion: Laparoscopic adrenalectomy is a safe and feasible approach to ...
  • Half-Pringle Maneuver: A Useful Tool in Laparoscopic Liver Resection
    Paulo Herman, Marcos V. Perini, Fabricio Coelho, William Saad, Luiz A.C. D'Albuquerque
    Journal of Laparoendoscopic& Advanced Surgical Techniquesand Part B, Videoscopy
    Mean tumor size was 4.1?cm (range, 2.6-6.0), and mean hospital stay was 3.1 days (1-5). There were 3 liver adenomas, 2 hepatocellular carcinomas, 1 metastatic melanoma, 1 ...
  • Cancer Incidence among Female Flight Attendants: A Meta-Analysis...
    Alessandra Buja, Giuseppe Mastrangelo, Egle Perissinotto, Francesco Grigoletto, Anna Chiara Frigo, Giuseppe Rausa, Valeria Marin, Cristina Canova, Francesca Dominici
    Journal of Women's Health
    Results: A total of seven published studies reporting SIR for several cancer types were extracted. Meta-analysis showed a significant excess of melanoma (meta-SIR 2.15, 95% ...

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