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  • China Dispatch: Clinical and Biobanking Activities
    ... It has just begun and is collecting samples from children with solid tumors, and blood from children with leukemia and genetic conditions. I am very interested in her work, and we ...
    10-15-2013
  • Young Companies in the Money: 25 Firms to Watch
    to fully fund the company's currently enrolling Phase III clinical study as first-line therapy in patients, 60-75 years of age, with secondary acute myeloid leukemia (AML). ...
    10-2-2013
  • Prepping for the Clinic
    ... a Phase II-ready asset for acute myeloid leukemia and other hematological cancers," Dr. ... skin lesions, celiac disease, and acute myeloid leukemia and other hematological cancers. ...
    10-1-2013
  • Advertorial: Advanced BioScience Laboratories (ABL)
    In the 1980s, the first known human retroviruses (HTLV-I and HTLV-II) and the human B cell leukemia virus (HHV-6) were isolated and characterized at ABL. ABL scientists were also ...
    10-1-2013
  • FDA Speeds Things Up
    ... and Johnson & Johnson's/Pharmacylics' ibrutinib (PCI-32765) for various types of leukemia and lymphoma. "We are getting meetings very quickly with the FDA," said Peter ...
    10-1-2013
  • Gene Trends: Which Ones Should You Be Studying Now?
    ... Mouse embryonic stem cell self-renewal may be maintained via activation by LIF (leukemia inhibitor factor) and its downstream component STAT3 (signal transducer and activator of ...
    10-1-2013
  • Takeover Targets: Who Is First on the List?
    2012 FDA approval for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both for patients resistant or intolerant to prior TKI therapy. ...
    9-24-2013
  • Selecting the Right Spike for Virus Clearance
    Minute Virus of Mice (MVM; parvovirus, nonenveloped, ~20 nm diameter) and Xenotropic Murine Leukemia Virus (X-MuLV; retrovirus, enveloped, ~100 nm diameter) stocks were prepared at ...
    9-15-2013
  • As Big Deals Resurface, Who's Next to the Altar?
    ... Acorda has had sales success and plans to add indications to its multiple sclerosis drug Ampyra; Ariad's leukemia drug Iclusig has been projected to reach $2.5 billion in annual ...
    9-9-2013
  • Otsuka Acquires Astex for $866M
    (decitabine), indicated for myelodysplastic syndromes and elderly acute myeloid leukemia. ... its experimental compound SGI-110 for acute myeloid leukemia and myelodysplastic syndrome. ...
    9-5-2013
  • FDA Speeds Things Up
    ... and Johnson & Johnson's/Pharmacylics' ibrutinib (PCI-32765) for various types of leukemia and lymphoma. "We are getting meetings very quickly with the FDA," said Peter ...
    9-3-2013
  • Tumor Suppressor May Actually Drive Cancer Development
    blocking a protein normally credited with suppressing leukemia may be a promising therapeutic strategy for an aggressive form of the disease called acute myeloid leukemia (AML). ...
    8-27-2013
  • Literature Review: New Combination of Targets Shows Promise for...
    (HDACIs) to induce apoptosis in leukemia cell lines with various genetic ... Acute myeloid leukemia (AML) has been the subject of intense research efforts in recent ...
    8-20-2013
  • Hematologic Diagnostics Go with the Flow
    ... in acute myeloid leukemia and myelodysplastic syndrome using flow cytometry methodologies. ... disease in pediatric patients with acute lymphoblastic leukemia after induction therapy. ...
    8-1-2013
  • Life Tech Licenses Dynabeads to Novartis, with Cancer Therapy...
    Earlier this year, a study in the New England Journal of Medicine described complete responses, one of them ongoing, in two children with leukemia. "Dynabeads ® CD3/CD28 CTS(tm) ...
    8-1-2013
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    Journal Articles

  • Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic...
    Mary Elizabeth Irwin, Nilsa Rivera-Del Valle, Joya Chandra
    Antioxidants & Redox Signaling
    Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities ... This dual nature has been exploited by leukemia cells to promote growth, survival, and ...
  • Leukemia Inhibitory Factor Promotes Recovery of Locomotor Function...
    Da Wei Zang, Surindar S. Cheema
    Journal of Neurotrauma
    Leukemia Inhibitory Factor Promotes Recovery of Locomotor Function following Spinal Cord ... neuroprotective drugs, namely leukemia inhibitory factor (LIF) and minocycline (MIN). ...
  • Leukemia Inhibitory Factor (LIF) Enhances Germ Cell Differentiation...
    Naoto Fukunaga, Takeshi Teramura, Yuta Onodera, Toshiyuki Takehara, Kanji Fukuda, Yoshihiko Hosoi
    Cellular Reprogramming
    Leukemia Inhibitory Factor (LIF) Enhances Germ Cell Differentiation from Primate Embryonic ... Leukemia inhibitory factor (LIF) has been reported as one of the important factors for ...
  • Leukemia Inhibitory Factor-Induced Stat3 Signaling Suppresses...
    Jen-Wei Liu, Yi-Chao Hsu, Chien-Yu Kao, Hong-Lin Su, Ing-Ming Chiu
    Stem Cells and Development
    Leukemia Inhibitory Factor-Induced Stat3 Signaling Suppresses Fibroblast Growth Factor ... Abstract In regular culture conditions with leukemia inhibitory factor (LIF), the majority ...

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