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Search Results - Lentiviral Vectors
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  • Highlights from AACR
    The Genesis platform uses recombinant adeno-associated viral (rAAV) vectors to achieve ... PerkinElmer launches its new RediFect lentiviral particles, customers will be able to ...
    5-15-2013
  • Advances in RNAi Tools and Technologies
    ... effects. siRNA molecules must overcome barriers like circulating nucleases and endosome acidity, but lentiviral transduction of shRNA vectors removes these potential hindrances. ...
    4-15-2013
  • SBIR Thinks Smaller
    ... for an efficient large-scale commercial system for manufacture of lentiviral gene therapy vectors in suspension cells. "We could not have done that without the support of ...
    1-22-2013
  • Literature Review: Mega-Selection
    The antibody genes from the selected phage were cloned into lentiviral vectors to allow phenotypic selections after infection of eukaryotic cells and integration of the antibody ...
    1-18-2013
  • Overcoming Drawbacks of Gene Silencing with RNAi
    Ten validation vectors containing different bioinformatically evaluated shRNA sequences ... The basis of VariCHECK is Sirion's All-In ONE vector inducible lentiviral system based on ...
    12-1-2012
  • Honing In On Gene Delivery Targets
    ... Many early trails with lentiviral vectors-"including ours"-were done with a noninfective particle to infective particle ratio on the order of 2,000-5,000:1, which is "not a very ...
    9-1-2012
  • Gene Therapy Shows Promise for Treating Beta-Thalassemia and...
    ... progenitors transduced with different amounts of lentiviral vectors could be useful for testing the potential of each lentiviral construct prior to bone marrow transplantation." ...
    3-28-2012
  • Harnessing Innovation to Improve Expression Systems
    ... proteins in human cell lines using novel lentiviral vectors, was developed by researchers at Albert Einstein College of Medicine and Seattle Children's Hospital Research Institute. ...
    3-15-2012
  • Cutting-Edge Approaches and Applications for RNAi
    ... Promoter Impact The Thermo Scientific SMARTvector 2.0 system utilizes lentiviral vectors to stably deliver and express gene-silencing reagents capable of entering the RNAi pathway. ...
    11-1-2011
  • The History and Promise of Gene Therapy
    ... application of lentiviral vectors for a genetic disease deployed an ex vivo bone marrow strategy in a lethal pediatric neurologic disease called adrenoleukodystrophy (ALD). ...
    10-1-2011
  • Advertorial: Sigma Life Science
    ... Our ever-expanding suite of custom RNAi services includes cloning, inducible vectors, large-scale and high-titer lentiviral particles, lentivirus production, and gene family sets. ...
    10-1-2011
  • Optimizing the Generation of iPS Cells
    obtained using retroviral vectors. Generation of human and mouse iPS cells is now routinely accomplished using a single, excisable polycistronic lentiviral vector that delivers all ...
    9-1-2011
  • Clinical Successes and New Technologies Revive Gene Therapy
    a temporary halt on all gene therapy trials using retroviral vectors in blood stem cells. ... They first removed CD34+ cells, then transfected the cells ex vivo with a lentiviral ...
    8-26-2011
  • Researchers Combine Stem Cell with Artificial Chromosome to Treat...
    ... To this end, the team says it is developing a platform for engineering mesoangioblasts from DMD patients that contain excisable lentiviral vectors expressing immortalizing genes. ...
    8-17-2011
  • Four Transcription Factors Prompt Conversion of Mature Human...
    The team initially tested whether forced expression of the BAM transcription factors could induce a neuronal fate in human pluripotent cells by using lentiviral vectors to ...
    5-26-2011
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    Journal Articles

  • Synthetic Gene Regulation Circuits for Control of Cell Expansion
    Tobias May, Milada Butueva, Sara Bantner, David Markusic, Jurgen Seppen, Roderick A.F. MacLeod, Herbert Weich, Hansjörg Hauser, Dagmar Wirth
    Tissue Engineering, Part A
    system relies on synthetic gene modules that employ positive feedback loops based on Tetracycline control. These gene modules were constructed and transduced by lentiviral vectors. ...
  • Specific and Stable Gene Transfer to Human Embryonic Stem Cells...
    Jung-Eun Jang, Kit Shaw, Xiao-Jin Yu, Denise Petersen, Karen Pepper, Carolyn Lutzko, Donald B. Kohn
    Stem Cells and Development
    Specific and Stable Gene Transfer to Human Embryonic Stem Cells Using Pseudotyped Lentiviral Vectors Stem Cells and Development Genetic modification of human embryonic stem cells ...
  • Human Involucrin Promoter Mediates Repression-Resistant and Compartmen...
    Wei-Li Di, Ekaterina Semenova, Fernando Larcher, Marcela Del Rio, John I. Harper, Adrian J. Thrasher, Waseem Qasim
    Human Gene Therapy and Part B: Methods
    We conclude that skin grafts modified with lentiviral vectors encoding INVOp offer a suitable platform for therapeutic gene therapy in Netherton syndrome, and our experience ...
  • Targeting Expression of the Leukemogenic PML-RARα Fusion Protein...
    Simone V. Ward, Thomas Sternsdorf, Niels-Bjarne Woods
    Human Gene Therapy and Part B: Methods
    Intraperitoneal injection of NB4 cells transduced with lentiviral vectors delivering PML-RARa-specific siRNA but not control siRNA prevented development of disease in nonobese ...

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