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Search Results - Lead Optimization
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  • Separation of Therapeutic Biomolecules
    ... to determine whether the water molecules lead to structural reorganization, bulk ... accelerate the optimization of chromatography process development for protein separation. ...
    5-1-2013
  • Single-Use Bioreactor Roundup
    ... and operator ease-of-use/workflow optimization, but we are also cautiously aware of ... It would also lead to users benefits like lower cost and better service levels in delivery ...
    4-15-2013
  • Advertorial: ACEA Biosciences
    ... discovery and development process from target validation, assay development, lead generation and optimization as well as preclinical toxicology and safety evaluation of compounds. ...
    4-15-2013
  • Predicting Drug Toxicity in Humans
    ... toxicity biomarkers during pre-clinical lead drug candidate optimization offers us a relatively high (95-99%) assurance against DILI despite the low incidence of occurrence." ...
    4-1-2013
  • Meeting the Bioassay Challenge
    ... Despite a focus on optimization, variability around response curves may still be observed. ... In-depth analyses of every assay condition can lead to identification of factors that may ...
    3-15-2013
  • Betting on Baculovirus Expression
    ... For large-scale process optimization, the scale-down approach is often employed to ... The effective implementation of a systematic scale-down approach can lead to significant ...
    3-15-2013
  • Next-Gen Gene Synthesis Opens a World of New Possibilities
    ... of a technology and unapologetic improvement and optimization of a manufacturing process. ... We must help lead the field of synthetic biology such that, to the extent we can impact ...
    3-4-2013
  • Growing the Biobased Economy
    ... to being actively engaged and helping to lead the way to more sustainable agriculture. ... scale, Field to Market's Fieldprint Calculator will enable real-world system optimization. ...
    2-21-2013
  • Isothermal PCR Gets Off The Dime
    ... and Taqman techniques having the market lead, and expected to see continued growth. ... This was a real technology endeavor because it not only required optimization of ...
    2-20-2013
  • Bringing Toxicity Prediction to Chemists' Desktops
    the reduction of toxicity risk with the other requirements for a successful, safe, and efficacious drug in hit-to-lead and lead optimization, according to officials at both firms. ...
    2-4-2013
  • Bridging the Conjugation Gap
    ... Incubation of the Fab drug conjugate with DTT does not lead to competitive deconjugation ... half-life by FcRn-mediated recycling, some pharmacokinetic optimization may be required. ...
    2-1-2013
  • Tumor Bank Lends Expertise to Drug Firms
    ... Broudy says the tumor bank helps with many of the stages of drug discovery and development including target identfication, target confirmation, patient selection, lead optimization...
    2-1-2013
  • Monsanto Buys Agradis Assets and Teams Up with SGI
    R&D investment strategy lead. The assets of Agradis not purchased by Monsanto include castor and sweet sorghum breeding and genetic optimization technologies, as well as a ...
    1-31-2013
  • GVK BIO Enters Second Deal of the Year
    GVK BIO will use its multidisciplinary discovery platform to advance these programs through lead optimization and IND candidate selection. GVK BIO Enters Second Deal of the Year
    1-28-2013
  • Addressing Key Issues in Biobanking
    ... warm air, but can also lead to frost buildup in the freezer, which may mask sample labels. ... "The idea is to improve sample optimization, create renewable biological ...
    1-15-2013
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    Journal Articles

  • Effect of Scaffold Stiffness on Myoblast Differentiation
    Meital Levy-Mishali, Janet Zoldan, Shulamit Levenberg
    Tissue Engineering, Part A
    Successful tissue engineering requires optimization of scaffold stiffness for a given ... On the other hand, excessively firm scaffold could not lead to parallel oriented myotube ...
  • Xeno-Free Plant-Derived Hydrolysate-Based Freezing of Human Embryonic...
    Veronique T'Joen, Ria Cornelissen, Maria Cornelissen
    Stem Cells and Development
    Fusion in the cryopreservation solution lead to the highest recovery ratio, thus this ... Further optimization protocols showed a doubling of the obtained recovery ratio after ...
  • Glycoprotein Ibα Receptor Instability Is Associated with Loss...
    Amélie Robert, Lucie Boyer, Nicolas Pineault
    Stem Cells and Development
    The development of culture processes for hematopoietic progenitors could lead to the ... Optimization of culture conditions to prevent these deleterious effects and to homogenize ...
  • Determination of Cryoprotectant for Magnetic Cryopreservation...
    Sheng-Yang Sean Lee, Chao-Hsuan Benson Sun, Tzong-Fu Kuo, Yen-Hua Huang, Jiiang-Huei Jeng, Jen-Chang Yang, Wei-Chung Vivian Yang
    Tissue Engineering, Part C: Methods
    and equilibration time for magnetic cryopreservation of dental pulp require optimization. ... during magnetic cryopreservation should lead to more satisfactory outcomes in clinical ...

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