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Search Results - Kinases
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  • Workings of Body's Master Energy Regulator Revealed
    while inhibition is straight forward, less is understood about the mechanism of hyperactivation of kinases. "Other research has revealed compounds that activate AMPK," said Dr. ...
    10-3-2013
  • Advertorial: Cell Sciences
    hormones, interferons, interleukins, kinases and phosphatases, lymphokines, neurotrophic factors, receptors, regulatory peptide factors, signal transduction mediators, and toxins. ...
    10-1-2013
  • Chemists Find New Way to Put the Brakes on Cancer
    The targeting of transcription factor-coactivator interfaces differs from the typical search for small molecules that target cellular kinases. Accordingly, it may represent a new ...
    9-9-2013
  • BEAMing for Cancer
    ... With multiple inhibitors of phosphoinositide 3-kinases currently in development, BEAMing has clear applications for clinical trial design and execution, as well as future clinical ...
    9-1-2013
  • Protein Linked to Alzheimer's-Like Symptoms Identified
    enzymes that phosphorylate eIF2alpha, kinases termed PERK and GCN2, in different ... PERK, demonstrating that removal of both kinases diminished memory deficits associated ...
    8-12-2013
  • Researchers Probe Proteins Instead of Mutations to Understand...
    to the kinase group. "The kinases play a part in the continuous reproduction process of tumor cells," adds Dr. Küster. "The wide variety of kinases shows how different these ...
    8-8-2013
  • Removing the Receptor Deconvolution Bottleneck
    ... Retrogenix' technology has identified many new drug targets on behalf of its partners. These have included receptor-type kinases, GPCRs, immunoglobulin superfamily members, anchor ...
    8-1-2013
  • Consortium to Study Alzheimer's Drug Candidate with $11.3M Bpifrance...
    Masitinib is a tyrosine kinase inhibitor designed to inhibit c-Kit and Lyn, two kinases specifically expressed in mast cells. As GEN reported last month, the road to a safe and ...
    7-23-2013
  • Genetic Screening Approach IDs New Targets for Lung Cancer
    alterations in three kinases, FGFR4, MAP3K9, and PAK5-they've found by taking this screening approach. Dr. Brognard et al. note that these mutated kinases are activating toward ...
    7-8-2013
  • HTRF Applications in New Drug Discovery
    as G protein-coupled receptors (GPCRs), kinases, and biomarkers. "HTRF brings fluorescent ... the activity of several intracellular kinases in multiple cell types. "Results from ...
    7-1-2013
  • Macrocycles Shake Up Small Molecules
    with potential drug effects against kinases. "This class of proteins, based on their ... target-based assays on pre-defined kinases by focusing on the intrinsic chemical ...
    6-15-2013
  • Acquired Drug Resistance in Cancer
    ... participating in a Phase III clinical trial of oral regorafenib, which inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR, and Raf kinases. ...
    6-1-2013
  • Roswell Park Joins Jasco to Develop Lead Agent for Cancer
    JP_11646 is among Jasco's PIM kinases, serine/threonine protein kinases with a structurally unique ATP binding pocket incorporated in all three isoforms, Pim-1, Pim-2, and Pim-3. ...
    5-31-2013
  • Fluorescence Lifetime Assays
    ... protein substrates, the FLEXYTE(tm) assay platform (Almac Group) has been configured for a number of important drug targets including proteases, protein kinases and phosphatases. ...
    5-15-2013
  • Cancer Diagnostics, Pushing the Boundaries
    ... The assay is based on an understanding of the relationship between overexpression of multiple oncogenes, including those encoding several families of receptor tyrosine kinases, and ...
    5-8-2013
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    Journal Articles

  • SnRK2 Protein Kinases-Key Regulators of Plant Response to Abiotic...
    Anna Kulik, Izabela Wawer, Ewa Krzywinska, Maria Bucholc, Grazyna Dobrowolska
    OMICS: A Journal of Integrative Biology
    Kinases-Key Regulators of Plant Response to Abiotic Stresses OMICS: A Journal of Integrative Biology The SnRK2 family members are plant-specific serine/threonine kinases involved ...
  • SnRK2 Protein Kinases-Key Regulators of Plant Response to Abiotic...
    Anna Kulik, Izabela Wawer, Ewa Krzywinska, Maria Bucholc, Grazyna Dobrowolska
    OMICS: A Journal of Integrative Biology
    Kinases-Key Regulators of Plant Response to Abiotic Stresses OMICS: A Journal of Integrative Biology Abstract The SnRK2 family members are plant-specific serine/threonine kinases ...
  • Apoptosis Signaling Kinases: From Stress Response to Health Outcomes
    Kohsuke Takeda, Isao Naguro, Hideki Nishitoh, Atsushi Matsuzawa, Hidenori Ichijo
    Antioxidants & Redox Signaling
    Apoptosis Signaling Kinases: From Stress Response to Health Outcomes Antioxidants & Redox ... A large body of evidence has revealed that a number of protein kinases are among such ...
  • Apoptosis Signaling Kinases: From Stress Response to Health Outcomes
    Kohsuke Takeda, Isao Naguro, Hideki Nishitoh, Atsushi Matsuzawa, Hidenori Ichijo
    Antioxidants & Redox Signaling
    Apoptosis Signaling Kinases: From Stress Response to Health Outcomes Antioxidants & Redox ... A large body of evidence has revealed that a number of protein kinases are among such ...

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