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Search Results - Kinases
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  • Protein Linked to Alzheimer's-Like Symptoms Identified
    enzymes that phosphorylate eIF2alpha, kinases termed PERK and GCN2, in different ... PERK, demonstrating that removal of both kinases diminished memory deficits associated ...
    8-12-2013
  • Researchers Probe Proteins Instead of Mutations to Understand...
    to the kinase group. "The kinases play a part in the continuous reproduction process of tumor cells," adds Dr. Küster. "The wide variety of kinases shows how different these ...
    8-8-2013
  • Removing the Receptor Deconvolution Bottleneck
    ... Retrogenix' technology has identified many new drug targets on behalf of its partners. These have included receptor-type kinases, GPCRs, immunoglobulin superfamily members, anchor ...
    8-1-2013
  • Consortium to Study Alzheimer's Drug Candidate with $11.3M Bpifrance...
    Masitinib is a tyrosine kinase inhibitor designed to inhibit c-Kit and Lyn, two kinases specifically expressed in mast cells. As GEN reported last month, the road to a safe and ...
    7-23-2013
  • Genetic Screening Approach IDs New Targets for Lung Cancer
    alterations in three kinases, FGFR4, MAP3K9, and PAK5-they've found by taking this screening approach. Dr. Brognard et al. note that these mutated kinases are activating toward ...
    7-8-2013
  • HTRF Applications in New Drug Discovery
    as G protein-coupled receptors (GPCRs), kinases, and biomarkers. "HTRF brings fluorescent ... the activity of several intracellular kinases in multiple cell types. "Results from ...
    7-1-2013
  • Macrocycles Shake Up Small Molecules
    with potential drug effects against kinases. "This class of proteins, based on their ... target-based assays on pre-defined kinases by focusing on the intrinsic chemical ...
    6-15-2013
  • Acquired Drug Resistance in Cancer
    ... participating in a Phase III clinical trial of oral regorafenib, which inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR, and Raf kinases. ...
    6-1-2013
  • Roswell Park Joins Jasco to Develop Lead Agent for Cancer
    JP_11646 is among Jasco's PIM kinases, serine/threonine protein kinases with a structurally unique ATP binding pocket incorporated in all three isoforms, Pim-1, Pim-2, and Pim-3. ...
    5-31-2013
  • Fluorescence Lifetime Assays
    ... protein substrates, the FLEXYTE(tm) assay platform (Almac Group) has been configured for a number of important drug targets including proteases, protein kinases and phosphatases. ...
    5-15-2013
  • Cancer Diagnostics, Pushing the Boundaries
    ... The assay is based on an understanding of the relationship between overexpression of multiple oncogenes, including those encoding several families of receptor tyrosine kinases, and ...
    5-8-2013
  • Harnessing the Power of Kinase Inhibitors
    The ~600 kinases that make up the human kinome comprise a group of exciting druggable ... the ATP binding pocket common to all kinases in their active form, as well as type II ...
    5-8-2013
  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    ... And researchers say, similarly as for other enzymatic targets such as kinases, the highly conserved structure of the catalytic domains of serine proteases, in particular the ...
    5-1-2013
  • Detecting Acquired Drug Resistance in Cancer
    ... participating in a Phase III clinical trial of oral regorafenib, which inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR, and Raf kinases. ...
    4-29-2013
  • Performing "Informative Clinical Trials" in Mice
    ... against several tyrosine kinases linked to cancer in HT-29 colorectal cancer cell-line derived and patient tumor-derived murine xenograft models of human colorectal cancer (CRC). ...
    4-17-2013
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    Journal Articles

  • Acute Effects of Interferon on Estrogen Receptor Function Do...
    A.P.F. Flint, D.R.E. Abayasekara, C.P.D. Wheeler-Jones, P.R. Riley, S. Kaluz, M. Kaluzova, E.L.R. Sheldrick, P.A. Fisher
    Journal of Interferon & Cytokine Research
    Acute Effects of Interferon on Estrogen Receptor Function Do Not Involve the Extracellular Signal-Regulated Kinases p42 mapk and p44 mapk Journal of Interferon & Cytokine Research
  • Transgenic Mice Targeting the Heart Unveil G Protein-Coupled...
    Guido Iaccarino, Walter J. Koch
    ASSAY and Drug Development Technologies
    Transgenic Mice Targeting the Heart Unveil G Protein-Coupled Receptor Kinases as Therapeutic Targets ASSAY and Drug Development Technologies GRKs critically regulate ßAR signaling ...
  • Opposing Effects of Age and Calorie Restriction on Molecular...
    Jason N. Peart, Louise See Hoe, Salvatore Pepe, Peter Johnson, John P. Headrick
    Rejuvenation Research
    Postischemic contractile dysfunction, cellular damage, and expression of regulators of autophagy/apoptosis and of prosurvival and prodeath kinases were assessed in myocardium from ...
  • Cell Cycle Regulation by Oncogenic Tyrosine Kinases in Myeloid...
    Margret S. Rodrigues, Mamatha M. Reddy, Martin Sattler
    Antioxidants & Redox Signaling
    Cell Cycle Regulation by Oncogenic Tyrosine Kinases in Myeloid Neoplasias: From Molecular Redox Mechanisms to Health Implications Antioxidants & Redox Signaling

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