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Search Results - Kinases
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  • Fluorescence Lifetime Assays
    ... protein substrates, the FLEXYTE(tm) assay platform (Almac Group) has been configured for a number of important drug targets including proteases, protein kinases and phosphatases. ...
    5-15-2013
  • Cancer Diagnostics, Pushing the Boundaries
    ... The assay is based on an understanding of the relationship between overexpression of multiple oncogenes, including those encoding several families of receptor tyrosine kinases, and ...
    5-8-2013
  • Harnessing the Power of Kinase Inhibitors
    The ~600 kinases that make up the human kinome comprise a group of exciting druggable ... the ATP binding pocket common to all kinases in their active form, as well as type II ...
    5-8-2013
  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    ... And researchers say, similarly as for other enzymatic targets such as kinases, the highly conserved structure of the catalytic domains of serine proteases, in particular the ...
    5-1-2013
  • Detecting Acquired Drug Resistance in Cancer
    ... participating in a Phase III clinical trial of oral regorafenib, which inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR, and Raf kinases. ...
    4-29-2013
  • Performing "Informative Clinical Trials" in Mice
    ... against several tyrosine kinases linked to cancer in HT-29 colorectal cancer cell-line derived and patient tumor-derived murine xenograft models of human colorectal cancer (CRC). ...
    4-17-2013
  • ArQule Regains Rights to AKT Inhibitor from Daiichi Sankyo
    ... to inhibit the Eg5 kinesin motor protein; and ARQ 736, designed to inhibit the RAF kinases. ARQ 092 is in an ongoing Phase I trial, from which ArQule said it would present ...
    4-1-2013
  • Targeting Protein-Protein Interactions
    ... a few DNA sequencing runs)," he explains. "We have successfully performed campaigns on enzymes such as kinases and anhydrase, identifying inhibitors with nanomolar affinities." Dr. ...
    2-15-2013
  • Ten Predictions that Will Transform Healthcare
    ... Another recently approved drug, Cometriq (cabozantinib), is an inhibitor of multiple receptor tyrosine kinases approved November 29 for treating progressive, metastatic medullary ...
    2-15-2013
  • Old Drug Plays New Tricks on Diabetes and Obesity
    Saltiel assures. The study, titled "An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice", was published online yesterday in ...
    2-11-2013
  • 10 Predictions That Will Transform Healthcare
    ... Another recently approved drug, Cometriq (cabozantinib), is an inhibitor of multiple receptor tyrosine kinases approved November 29 for treating progressive, metastatic medullary ...
    1-17-2013
  • Epigenetics: Promising Field Delivers
    ... These results pointed toward the hypermethylation of DOK7, which encodes the substrate and an activator of receptor tyrosine kinases, as either a potential candidate for the early ...
    1-15-2013
  • Sanford-Burnham Taps Intrexon to Speed Up iPSC Research
    The most potent inhibitors targeted three kinases-AurkA, P38, and IP3K-according to the ... to create pluripotent stem cells, you are probably activating a large number of kinases. ...
    1-3-2013
  • New Form of Human Cell Division Discovered
    ... In the first approach, his team interrogates the function of specific kinases such as Plk1 to determine how these control human cell division and evaluate the potential worth as a ...
    12-18-2012
  • Advertorial: Introduction of a Convenient, Non-Radioactive Universal...
    Kinases catalyze the transfer of the γ-phosphate from adenosine 5´-triphosphate (ATP) to ... Kinases regulate virtually all cellular activities and have important roles in cell ...
    12-1-2012
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    Journal Articles

  • The Biochemistry, Chemistry and Physiology of the Isoflavones...
    Stephen Barnes
    Lymphatic Research and Biology
    This estrogenicity is not the only mechanism by which isoflavones may have bioactivity-they inhibit tyrosine kinases, have antioxidant activity, bind to and activate peroxisome ...
  • Sorafenib: Rays of Hope in Thyroid Cancer
    Leonidas H. Duntas, Renato Bernardini
    Thyroid
    Thyroid Background: Sorafenib (BAY 43-9006) is an inhibitor of multiple-receptor tyrosine kinases involved in tumor growth and angiogenesis, which can be advantageously ...
  • The Role of the Extracellular Signal-Related Kinase Signaling...
    Qihai Liu, Lian Cen, Heng Zhou, Shuo Yin, Guangpeng Liu, Wei Liu, Yilin Cao, Lei Cui
    Tissue Engineering, Part A
    At molecular levels, this study investigated the contribution of one of the main members of mitogen-activated protein kinases (MAPKs), extracellular signal-related kinase (ERK), to ...
  • 5-Azacytidine Induces Cardiac Differentiation of Human Umbilical...
    Qian Qian, Hui Qian, Xu Zhang, Wei Zhu, Yongmin Yan, Shengqin Ye, Xiujuan Peng, Wei Li, Zhe Xu, Lingyun Sun, Wenrong Xu
    Stem Cells and Development
    Further study revealed that 5-Aza treatment activated extracellular signal related kinases (ERK) in hucMSCs, but protein kinase C showed no response to 5-Aza administration. U0126, ...

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