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Search Results - KRAS
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  • Multitasking Multiplex Assays
    ... Results show that we are now detecting seven different somatic cell mutations involving the KRAS colon cancer marker in FFPE tumor blocks," added Dr. Montagna. "Our mandate is not ...
    10-15-2013
  • Amgen Grows Cancer Holdings with $10.4B Onyx Acquisition
    ... oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy; as well as for locally advanced, unresectable or ...
    8-26-2013
  • Acquired Drug Resistance in Cancer
    ... They had previously reported that KRAS mutant alleles emerged in the circulation of ... at the 50% of patients in which KRAS mutations had not emerged during anti-EGFR therapy. ...
    6-1-2013
  • Pharma Touting Phase II/III Wins in Run-Up to ASCO
    The firm said that activating mutations in KRAS (beyond exon 2) and mutations in ... survival among patients with wild-type KRAS exon 2 metastatic colorectal cancer ...
    5-16-2013
  • Amgen Forms Joint Venture to Sell Vectibix in China
    that Vectibix was at least as effective as rival drug Erbitux (cetuximab), marketed by Eli Lilly and Merck Serono, as a single agent for mCRC patients with wild-type KRAS tumors. ...
    5-10-2013
  • Companion Diagnostics: 52 Pick-Up
    ... treatment is being considered. therascreen KRAS RGQ PCR Kit Sponsor/Developer: Qiagen ... of seven somatic mutations in the human KRAS oncogene, using DNA extracted from FFPE ...
    5-9-2013
  • Detecting Acquired Drug Resistance in Cancer
    ... They had previously reported that KRAS mutant alleles emerged in the circulation of ... In a new approach Siravegna and colleagues had a look at the 50% of patients in which KRAS ...
    4-29-2013
  • Top 20 Best-Selling Drugs Approved and Launched During 2012
    ... oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy Date of FDA approval: September 27, 2012 #6. ...
    4-4-2013
  • Women and Smoking
    ... 19 deletions and L858R) and KRAS (G12, G13) examining correlations with demographic, clinical, and smoking history data. The researchers focused on KRAS, which is frequently ...
    4-3-2013
  • Development and Evolution of PCR
    ... genetic targets, such as cystic fibrosis carrier screening, and many focus on detecting inherited (e.g., BRACA1 and BRACA2) mutations and somatic mutations in tumors (e.g., KRAS). ...
    4-1-2013
  • Advertorial: Swift Biosciences
    ... Swift has developed myT Primers for the common mutations in BRAF and KRAS genes to demonstrate the superior performance capabilities of the technology for mutation detection. ...
    4-1-2013
  • Personalized Medicine: From Biomarkers to Companion Diagnostics
    A number of biomarkers, such as KRAS and EGFR mutations, could only be established after a ... were asked to select patients with a positive EGFR biomarker or a KRAS biomarker. ...
    3-26-2013
  • Personalized Medicine: Translation of Concepts
    Examples include Her-2/neu (Trastuzumab/Lapatinib), KRAS (Cetuximab/Panitumomab), BRAF (Vemurafenib), and CCR5 (Maraviroc). We Lack Model Systems to Predict Drug Response In our ...
    3-19-2013
  • Molecular Characterization of CTCs
    ... Figure 3. KRAS mutation detection in colorectal cancer patients. qPCR readouts identify a ... As one example, Fluxion has developed a sensitive KRAS mutation detection panel for use ...
    3-15-2013
  • Lab21, IntegraGen Aim to SPARQ New Cancer Diagnostic
    response to EGFR inhibitor therapy in KRAS wild-type patients who have metastatic ... stratified by determining mutations in the KRAS gene, the companies say that microRNA ...
    2-22-2013
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    Journal Articles

  • Comparison of KRAS Mutation Tests in Colorectal Cancer Patients
    Veysel Sabri Hancer, Murat Buyukdogan, Ilknur Türkmen, Nuray Bassullu, Tuncay Altug, Reyhan Diz-Kucukkaya, Gulen Bulbul-Dogusoy, Gokhan Demir
    Genetic Testing and Molecular Biomarkers
    Comparison of KRAS Mutation Tests in Colorectal Cancer Patients Genetic Testing and Molecular Biomarkers The KRAS pathway and studies evaluating KRAS as a prognostic marker in ...
  • PTPN11 and KRAS Gene Analysis in Patients with Noonan and Noonan...
    Amanda Salem Brasil, Alexandre C. Pereira, Luciana Turolla Wanderley, Chong Ae Kim, Alexsandra C. Malaquias, Alexander A.L. Jorge, José Eduardo Krieger, Débora Romeo Bertola
    Genetic Testing and Molecular Biomarkers
    PTPN11 and KRAS Gene Analysis in Patients with Noonan and Noonan-Like Syndromes Genetic ... In Noonan syndrome (NS), four genes of this pathway (PTPN11, SOS1, RAF1, and KRAS) are ...
  • The Proto-Oncogene KRAS and BRAF Profiles and Some Clinical Characteri...
    Filiz OZEN, Semra OZDEMIR, Ebru ZEMHERI, Gizem HACIMUTO, Fatma Silan, Ozturk Ozdemir
    Genetic Testing and Molecular Biomarkers
    The Proto-Oncogene KRAS and BRAF Profiles and Some Clinical Characteristics in Colorectal ... of the KRAS and BRAF mutations in Turkish patients with colorectal cancer (CRC). ...
  • A Novel Polymorphism in Codon 25 of the KRAS Gene Associated...
    Vishmadeb Pramanik, Biswanath N. Sarkar, Madhuchanda Kar, Gautam Das, Barman K. Malay, Khannam K. Sufia, Bhaskar V.K.S. Lakkakula, Rao R. Vadlamudi
    Genetic Testing and Molecular Biomarkers
    A Novel Polymorphism in Codon 25 of the KRAS Gene Associated with Gallbladder Carcinoma ... could be of importance in this regard. KRAS is the most frequently mutated member and ...

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